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Heart Failure clinical trials in Baltimore, MD

24 studies for Heart Failure are looking for participants at sites in and around Baltimore (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

RecruitingPhase 3
  • Ascension Saint Agnes Heart Care, Baltimore
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06935370

A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

RecruitingPhase 3
  • Ascension Saint Agnes Heart Care, Baltimore
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06424288

Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

RecruitingObservational studyHealthy volunteers welcome
  • Johns Hopkins University, Baltimore
Ages 30 and older · All sexes · Updated Sep 29, 2026 · NCT06517186

A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF

RecruitingPhase 3
  • Research Site, Baltimore
  • Research Site, Annapolis · 22 mi away
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07761117

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

RecruitingPhase 3
  • University of Maryland Medical Center, Baltimore
Ages 18 to 85 · All sexes · Updated Sep 24, 2026 · NCT06736574

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

RecruitingPhase 3
  • Ascension Saint Agnes Heart Care, Baltimore
  • Johns Hopkins University, Baltimore
Ages 18 to 99 · All sexes · Updated Sep 16, 2026 · NCT07037459

Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

RecruitingPhase 3
  • Research Site, Baltimore
  • Research Site, Lutherville-Timonium · 10 mi away
Ages 40 and older · All sexes · Updated Sep 15, 2026 · NCT06677060

A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

RecruitingPhase 3
  • Baltimore, MD Investigative Site 10101, Baltimore
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06008197

Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

Recruiting
  • University of Maryland Medical Center, Baltimore
  • The Johns Hopkins Hospital, Baltimore
Ages 18 to 100 · All sexes · Updated Sep 9, 2026 · NCT06310031

A Study of EDG-15400 in Adults With Heart Failure With Preserved Ejection Fraction (EQUINOX-HFpEF)

RecruitingPhase 2
  • Local Institution - 106, Baltimore
Ages 30 to 84 · All sexes · Updated Aug 31, 2026 · NCT07795814

Rilonacept in Subjects With Cardiac Sarcoidosis

RecruitingPhase 2
  • Johns Hopkins University, Baltimore
Ages 18 to 80 · All sexes · Updated Aug 20, 2026 · NCT06660732

A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

RecruitingPhase 3
  • Ascension Saint Agnes Heart Ca, Baltimore
  • Mercy Medical Center, GI Research, Baltimore
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07567001

Alleviant ALLAY-HF Study

Recruiting
  • Johns Hopkins Medical Institution, Baltimore
Ages 40 and older · All sexes · Updated Aug 14, 2026 · NCT05685303

Understanding and Addressing Risks of Low Socioeconomic Status and Diabetes for Heart Failure

Recruiting
  • Johns Hopkins Center for Health Equity, Baltimore
Ages 30 to 70 · All sexes · Updated Jul 15, 2026 · NCT06364644

PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

Recruiting
  • MedStar, Baltimore
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05934487

A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

RecruitingPhase 2
  • Ascension Saint Agnes Heart Care, Baltimore
Ages 18 to 79 · All sexes · Updated May 27, 2026 · NCT06991257

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

Recruiting
  • Johns Hopkins, Baltimore
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT03142152

Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism

RecruitingObservational studyHealthy volunteers welcome
  • Johns Hopkins Medical Institutions, Baltimore
Ages 18 and older · All sexes · Updated Mar 9, 2026 · NCT00181259

Adult Congenital Heart Disease International EValuation of the Effectiveness of SGLT2i Registry

RecruitingObservational study
  • Johns Hopkins University, Baltimore
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT06932081

Prospective Observational Study of the ICD in Sudden Cardiac Death Prevention

RecruitingObservational study
  • University of Maryland Medical Center, Baltimore
  • Johns Hopkins University School of Medicine, Baltimore
Ages 18 to 85 · All sexes · Updated Jan 20, 2026 · NCT00733590

Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure

RecruitingObservational study
  • Johns Hopkins Hospital, Baltimore
Ages 18 to 90 · All sexes · Updated Jan 12, 2026 · NCT06299436

Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC

RecruitingPhase 1
  • Johns Hopkins University, Baltimore
Ages 18 to 65 · All sexes · Updated Feb 6, 2025 · NCT06228924

About Heart Failure

Heart failure, or congestive heart failure (CHF), means the heart can't pump enough blood. Learn about the signs, symptoms, and causes.

More about Heart Failure on MedlinePlus

Heart Failure trials in other cities

Other studies in Baltimore

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.