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Breast Cancer clinical trials in Baltimore, MD

47 studies for Breast Cancer are looking for participants at sites in and around Baltimore (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • Johns Hopkins University, Baltimore
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06172478

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

RecruitingPhase 3
  • Mercy Medical Center - Baltimore ( Site 0015), Baltimore
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06966700

Phase IIIb Study of Ribociclib + ET in Early Breast Cancer

RecruitingPhase 3
  • Mercy Medical Center, Baltimore
Ages 18 to 100 · All sexes · Updated Sep 23, 2026 · NCT05827081

Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

RecruitingPhase 3
  • Clinical Trial Site, Baltimore
  • Clinical Trial Site, Baltimore
  • Clinical Trial Site, Annapolis · 22 mi away
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07085767

A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

RecruitingPhase 1
  • United Theranostics, Glen Burnie · 9 mi away
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213791

Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies

RecruitingPhase 2
  • Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07340541

ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer

RecruitingPhase 3
  • Saint Agnes Hospital, Clinical Research Center, Baltimore
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07173751

A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

RecruitingPhase 3
  • Mercy Medical Center, Baltimore
  • Ascension St. Agnes Hospital, Baltimore
  • Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT06492616

A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

RecruitingPhase 1/2
  • Research Site, Baltimore
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT05123482

PET Dynamics to Response-Adapted Neoadjuvant Therapy in TNBC

RecruitingPhase 2
  • Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore
  • Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore
Ages 18 and older · Women · Updated Sep 3, 2026 · NCT06245889

Cardiometabolic Screening Program

Recruiting
  • Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT05386719

A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

RecruitingPhase 3
  • University of Maryland, Baltimore
  • Velocity Clinical Research, Annapolis · 22 mi away
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06790693

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

RecruitingPhase 3
  • Sidney Kimmel Comprehensive Cancer Center (SKCCC) at Johns Hopkins, Baltimore
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06982521

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

RecruitingPhase 3
  • University of Maryland/Greenebaum Cancer Center, Baltimore
  • Mercy Medical Center, Baltimore
  • Greater Baltimore Medical Center, Baltimore
  • and 8 more
Ages 18 to 60 · Women · Updated Sep 2, 2026 · NCT05879926

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Mercy Medical Center, Baltimore
  • Sinai Hospital of Baltimore, Baltimore
  • MedStar Franklin Square Medical Center/Weinberg Cancer Institute, Baltimore
  • and 2 more
Ages 40 to 75 · All sexes · Updated Sep 2, 2026 · NCT05334069

A Pivotal Phase II Clinical Trial of Utidelone Injection Plus Capecitabine in HER2-negative Breast Cancer Patients With Brain Metastases

RecruitingPhase 2
  • The Johns Hopkins Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore
Ages 18 and older · All sexes · Updated Aug 21, 2026 · NCT06764940

Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

RecruitingPhase 3
  • Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT06500481

Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects

RecruitingPhase 3
  • Maryland Oncology Hematology, Annapolis · 22 mi away
Ages 18 to 100 · All sexes · Updated Aug 6, 2026 · NCT05232916

E-Mindfulness Approaches for Living After Breast Cancer

RecruitingPhase 3
  • Maryland Proton Treatment Center, Baltimore
  • University of Maryland/Greenebaum Cancer Center, Baltimore
  • MedStar Franklin Square Medical Center/Weinberg Cancer Institute, Baltimore
  • and 7 more
Ages 18 to 50 · All sexes · Updated Aug 4, 2026 · NCT06748222

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

RecruitingPhase 2
  • The John Hopkins Hospital, Baltimore
Ages 8 and older · All sexes · Updated Jul 27, 2026 · NCT05503797

Conventionally Fractionated vs. Hypofractionated Comprehensive Nodal Irradiation for Breast Cancer Using Pencil Beam Scanning Proton Therapy

RecruitingPhase 3
  • Maryland Proton Treatment Center, Baltimore
Ages 19 and older · Women · Updated Jul 10, 2026 · NCT05856773

Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal Metastasis

RecruitingPhase 2
  • Sidney Kimmel Comprehensive Cancer Center, Baltimore
Ages 18 and older · All sexes · Updated Jul 2, 2026 · NCT02422641

EXoPERT EMERALD Clinical Study

RecruitingObservational studyHealthy volunteers welcome
  • John Hopkins University, Baltimore
Ages 45 and older · All sexes · Updated Jul 1, 2026 · NCT07186296

Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

RecruitingPhase 3
  • Johns Hopkins Kimmel Cancer Center, Baltimore
Ages 18 and older · All sexes · Updated Jun 22, 2026 · NCT05696626

CD40 Agonist, Flt3 Ligand, and Chemotherapy in HER2 Negative Breast Cancer

RecruitingPhase 1
  • Johns Hopkins University, Baltimore
Ages 18 to 99 · All sexes · Updated Jun 17, 2026 · NCT05029999

Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

RecruitingPhase 1
  • Advanced Molecular Imaging and Therapy, Glen Burnie · 9 mi away
  • United Theranostics - Chesapeake, Glen Burnie · 9 mi away
Ages 18 and older · All sexes · Updated Jun 11, 2026 · NCT05283330

Phase 1 Study of CLR 125 in Triple Negative Breast Cancer

RecruitingPhase 1
  • United Theranostics, Glen Burnie · 9 mi away
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT07311993

A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.

RecruitingPhase 3
  • Mfsmc-Hjwci, Baltimore
  • Maryland Oncology Hematology P.A., Annapolis · 22 mi away
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT07062965

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

RecruitingPhase 3
  • University of Maryland/Greenebaum Cancer Center, Baltimore
  • Greater Baltimore Medical Center, Baltimore
  • Saint Agnes Hospital, Baltimore
  • and 7 more
Ages 50 to 70 · All sexes · Updated Apr 23, 2026 · NCT04852887

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

RecruitingObservational study
  • University of Maryland/Greenebaum Cancer Center, Baltimore
  • Sinai Hospital of Baltimore, Baltimore
  • UM Saint Joseph Medical Center, Towson · 8 mi away
  • and 1 more
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT06418204

The Effects of Treating Insomnia on Behavioral Weight Loss Outcomes in Survivors of Breast Cancer

Recruiting
  • Sidney Kimmel Comprehensive Cancer Center, the Avon Foundation Breast Center at Johns Hopkins, Baltimore
  • Johns Hopkins Bayview, Baltimore
  • Johns Hopkins Kimmel Cancer Center at Greenspring Station, Lutherville · 9 mi away
Ages 18 and older · Women · Updated Feb 23, 2026 · NCT05780814

GammaPod Dose Escalation Radiation for Early Stage Breast Cancer

Recruiting
  • UMMC, Baltimore
  • Baltimore Washington Medical Center, Glen Burnie · 9 mi away
  • Upper Chesapeake Health, Bel Air · 22 mi away
Ages 45 and older · Women · Updated Feb 20, 2026 · NCT04234386

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

RecruitingPhase 1
  • Johns Hopkins - Sidney Kimmel Comprehensive Cancer Center, Baltimore
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT06778863

EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)

RecruitingObservational study
  • Weinberg Center at Mercy, Baltimore
  • Greater Baltimore Medical Center, Baltimore
  • Sinai Hospital of Baltimore, Baltimore
  • and 3 more
Ages 18 and older · All sexes · Updated Jan 20, 2026 · NCT06401421

Metabotyping of Broccoli Microgreen in Obese Breast Cancer Survivors

Recruiting
  • Breast Evaluation and Treatment Program, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore
All ages · Women · Updated Dec 23, 2025 · NCT07032545

Study in Patients With Breast Cancer Leptomeningeal Metastasis

RecruitingObservational study
  • Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore
18 Weeks · All sexes · Updated Nov 28, 2025 · NCT06638294

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Baltimore
  • Massive Bio SYNERGY-AI site, Towson · 8 mi away
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

The Cancer of the Pancreas Screening-5 CAPS5)Study

RecruitingPhase 3
  • Johns Hopkins Hospital, Baltimore
Ages 18 and older · All sexes · Updated Oct 9, 2025 · NCT02000089

S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

RecruitingPhase 3
  • UM Upper Chesapeake Medical Center, Bel Air · 22 mi away
Ages 18 and older · All sexes · Updated Oct 8, 2025 · NCT03418961

Phase II Protocol of Proton Therapy for Partial Breast Irradiation in Early Stage Breast Cancer

RecruitingPhase 2
  • Maryland Proton Treatment Center, Baltimore
Ages 50 and older · Women · Updated Sep 9, 2025 · NCT01766297

MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles

RecruitingObservational study
  • Mercy Medical Center, Baltimore
  • Johns Hopkins Hospital, Baltimore
  • Luminis Health Center for Cancer & Blood Disorders, Annapolis · 22 mi away
Ages 18 and older · All sexes · Updated Aug 20, 2025 · NCT03053193

A Phase 2 Study of PCS6422 With Capecitabine in Patients With Advanced or Metastatic Breast Cancer

RecruitingPhase 2
  • University of Maryland Medical Center (UMMC), Baltimore
Ages 18 and older · All sexes · Updated Jun 19, 2025 · NCT06568692

A Trial of AMXI-5001 for Treatment in Patients With Advanced Malignancies

RecruitingPhase 1/2
  • Johns Hopkins, Baltimore
Ages 18 and older · All sexes · Updated May 1, 2025 · NCT04503265

First in Human Phase 1 Study of AG01 Anti-Progranulin/GP88 Antibody in Advanced Solid Tumor Malignancies

RecruitingPhase 1
  • University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore
Ages 18 and older · All sexes · Updated Nov 28, 2022 · NCT05627960

About Breast Cancer

Breast cancer is a cancer that starts in the breast tissue, when cells change and grow out of control. These extra cells can form a mass called a tumor.

More about Breast Cancer on MedlinePlus

Breast Cancer trials in other cities

Other studies in Baltimore

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.