Home › Metastatic Cancer › California › Los Angeles
Metastatic Cancer clinical trials in Los Angeles, CA
57 studies for Metastatic Cancer are looking for participants at sites in and around Los Angeles (within about 30 miles). Open a study to see who can join and how to contact the study team.
Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial
RecruitingPhase 2
- The Angeles Clinic and Research Institute - West Los Angeles Office, Los Angeles
- Cedars-Sinai Medical Center, Los Angeles
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
RecruitingPhase 1
- UCLA Department of Medicine-Hematology/Oncology, Los Angeles
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
RecruitingPhase 1/2
- UCLA Jonsson Comprehensive Cancer Center, Los Angeles
- USC Norris Comprehensive Cancer Center, Los Angeles
A Study of HC-7366 in Combination With Belzutifan (WELIREG™) in Patients With Renal Cell Carcinoma
RecruitingPhase 1
- Cedars-Sinai Medical Center, Los Angeles
A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors
RecruitingPhase 1
- University of California - Los Angeles, Los Angeles
Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors
RecruitingPhase 1
- University of California Los Angeles, Los Angeles
Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors
RecruitingPhase 2/3
- Norris Comprehensive Cancer Center, Los Angeles
A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations
RecruitingPhase 1/2
- Children's Hospital Los Angeles, Los Angeles
- University of California at Los Angeles, Los Angeles
A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
RecruitingPhase 2/3
- Cedars-Sinai Cancer at Cedars-Sinai Medical Center, Los Angeles
- UCLA Department of Medicine - Hematology/Oncology, Los Angeles
Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
RecruitingPhase 3
- Oncura Health - Good Samaritan, Los Angeles
- California Research Institute, Los Angeles
Intratumoral N17350 in Advanced Solid Tumors
RecruitingPhase 1/2
- The Angeles Clinic and Research Institute, Los Angeles
- UCLA - Jonsson Comprehensive Cancer Center, Los Angeles
Safety and Preliminary Anti-Tumor Activity of TYRA-430 in Advanced Hepatocellular Carcinoma and Other Solid Tumors With Activating FGF/FGFR Pathway Aberrations
RecruitingPhase 1
- USC Norris Comprehensive Cancer Center, Los Angeles
A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer
RecruitingPhase 3
- UCLA Hematology/Oncology - Westwood (Building 100), Los Angeles
A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract
RecruitingPhase 3
- TRIO-US (Translational Research in Oncology-US), Los Angeles
- UCLA Hematology/Oncology - Santa Monica, Los Angeles
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
RecruitingPhase 3
- USC/Norris Comprehensive Cancer Center, Los Angeles
EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors
RecruitingPhase 1/2
- California Research Institute (CRI), Los Angeles
A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)
RecruitingPhase 1/2
- UCLA Hematology & Oncology ( Site 0003), Los Angeles
CREO - Microwave Ablation Feasibility Study
Recruiting
- Cedars Sinai, Los Angeles
CR-001 in Adult Participants With Locally Advanced or Metastatic Solid Tumors
RecruitingPhase 1/2
- Clinical Study Site, Los Angeles
A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors
RecruitingPhase 1
- USC/Norris Comprehensive Cancer Center, Los Angeles
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
RecruitingPhase 3
- Cedars-Sinai Medical Center, Los Angeles
AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)
RecruitingPhase 1/2
- Avenzo Therapeutics Recruiting Site, Los Angeles
- Avenzo Therapeutics Recruiting Site, Los Angeles
A Study of IDP-001 in Advanced or Metastatic Solid Tumors
RecruitingPhase 1/2
- START Los Angeles, Los Angeles
Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.
RecruitingPhase 3
- Los Angeles Cancer Network, Los Angeles
- Cedars-Sinai Cancer at Cedars-Sinai Medical Facility, Los Angeles
- Los Angeles Cancer Network_Century City, Los Angeles
- and 3 more
A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors
RecruitingPhase 1
- The Angeles Clinic, Los Angeles
- UCLA, Los Angeles
A Study to See if Giving Fianlimab and Cemiplimab Together is Better Than Cemiplimab Alone at Treating Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
RecruitingPhase 2
- University of California Los Angeles, Los Angeles
- Samuel Oschin Cancer Center, Los Angeles
FORAGER-1: A Study of Vepugratinib (LY3866288; LOXO-435) in Participants With Cancer With a Change in a Gene Called FGFR3
RecruitingPhase 1
- University of California, Los Angeles (UCLA) - Division of Hematology-Oncology, Los Angeles
A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer
RecruitingPhase 2
- Research Site, Los Angeles
FOG-001 in Locally Advanced or Metastatic Solid Tumors
RecruitingPhase 1/2
- University of California, Los Angeles (UCLA), Los Angeles
A Study of MGC026 in Participants With Advanced Solid Tumors
RecruitingPhase 1
- The Angeles Clinic and Research Institute, Los Angeles
A Study of mRNA-4106 or mRNA-4200 Administered Alone or in Combination With Anti-Cancer Agents in Participants With Solid Tumors
RecruitingPhase 1
- START Los Angeles, Los Angeles
Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes
RecruitingPhase 1
- Los Angeles General Medical Center, Los Angeles
- USC / Norris Comprehensive Cancer Center, Los Angeles
Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors
RecruitingPhase 1
- Keck Medicine of USC Koreatown, Los Angeles
- Los Angeles General Medical Center, Los Angeles
- USC / Norris Comprehensive Cancer Center, Los Angeles
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
RecruitingPhase 1/2
- USC Norris Comprehensive Cancer Center, Los Angeles
Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors
RecruitingPhase 1/2
- The Angeles Clinic and Research Institute, Los Angeles
A Study of PYX-201 in Advanced Solid Tumors
RecruitingPhase 1
- Ronald Reagan UCLA Medical Center, Los Angeles
A Phase 1 Dose-escalation Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation
RecruitingPhase 1
- Cedars-Sinai Medical Center, Los Angeles
REMASTer: REcurrent Brain Metastases After SRS Trial
Recruiting
- UCLA, Los Angeles
Abiraterone, Enzalutamide, or Apalutamide in Castrate-sensitive Prostate Cancer.
RecruitingPhase 2
- VA Greater Los Angeles Healthcare System, Los Angeles
BBO-11818 in Adult Subjects With KRAS Mutant Cancer
RecruitingPhase 1
- The Angeles Clinic and Research Institute - West Los Angeles Office, Los Angeles
Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)
RecruitingPhase 3
- UCLA Hematology Oncology Santa Monica, Los Angeles
Safety and Efficacy of EIK1001 in Combo With Pembro Versus Placebo and Pembro as First-Line Therapy in Patients With Advanced Melanoma.
RecruitingPhase 2/3
- Helios Clinical Research, Los Angeles
A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body
RecruitingPhase 1/2
- USC Norris Comprehensive Cancer Center, Los Angeles
A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors
RecruitingPhase 1/2
- Cedars-Sinai Medical Center, Los Angeles
Placebo-Controlled Trial of IFx-Hu2.0 Followed By Pembrolizumab In Checkpoint Inhibitor Naïve Participants With Advanced Or Metastatic Merkel Cell Carcinoma
RecruitingPhase 2/3
- USC Norris Comprehensive Cancer Center, Los Angeles
A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma
RecruitingPhase 3
- University of California Los Angeles, Los Angeles
A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma
RecruitingPhase 2/3
- The Angeles Clinic and Research Institute, Los Angeles
- University of California Los Angeles, Los Angeles
Isunakinra Alone and in Combination With Pembrolizumab in Patients With Colorectal Cancer (MSS)
RecruitingPhase 2
- USC/Norris Cancer Center, Los Angeles
A Phase 1 Study of CPO301 in Adult Patients With Advanced or Metastatic Solid Tumors
RecruitingPhase 1
- USC Norris Comprehensive Cancer Center, Los Angeles
Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors
RecruitingPhase 1
- UCLA / Jonsson Comprehensive Cancer Center, Los Angeles
A Dose Finding Phase 1 of Sarilumab Plus Capecitabine in HER2/Neu-Negative Metastatic Breast Cancer and a Single-arm, Historically-controlled Phase 2 Study of Sarilumab Plus Capecitabine in Stage I-III Triple Negative Breast Cancer With High-Risk Residual Disease (EMPOWER)
RecruitingPhase 1/2
- Los Angeles General Medical Center, Los Angeles
- USC/Norris Comprehensive Cancer Center, Los Angeles
Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes
Recruiting
- Cedars-Sinai Medical Center, Los Angeles
A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation
RecruitingPhase 1
- USC - Norris Comprehensive Cancer Center, Los Angeles
Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen
RecruitingPhase 3
- Usc Norris Comprehensive Cancer Center, Los Angeles
Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma.
RecruitingPhase 1
- USC Norris Comprehensive Cancer Center, Los Angeles
A Study of NX-1607 in Adults With Advanced Malignancies
RecruitingPhase 1
- University of Southern California, Los Angeles
Highly Selective CDK7 Inhibitor Q901 in Selected Advanced Solid Tumors
RecruitingPhase 1/2
- University of Southern California, Los Angeles
Metastatic Cancer trials in other cities
- Houston, TX104 studies
- New York City, NY93 studies
- Nashville, TN70 studies
- Boston, MA63 studies
- St. Louis, MO54 studies
- Arlington, VA53 studies
- Philadelphia, PA46 studies
- Chicago, IL45 studies
- San Antonio, TX44 studies
- Washington, DC43 studies
- Dallas, TX42 studies
- Seattle, WA39 studies
Other studies in Los Angeles
- Non-Small Cell Lung Cancer87 studies
- Cancer (all types)74 studies
- Breast Cancer73 studies
- Prostate Cancer61 studies
- Colorectal Cancer59 studies
- Ovarian Cancer50 studies
- Lung Cancer45 studies
- Head and Neck Squamous Cell Carcinoma42 studies
- Pancreatic Cancer35 studies
- Endometrial Cancer34 studies
- Melanoma34 studies
- Triple-Negative Breast Cancer27 studies
From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.