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Colorectal Cancer clinical trials in Illinois
51 studies for Colorectal Cancer are looking for participants at sites in Illinois.
Cities in Illinois
- Chicago33 studies
- Arlington Heights12 studies
- Peoria12 studies
- Evanston10 studies
- Cicero10 studies
- Springfield9 studies
- North Peoria7 studies
- Bloomington7 studies
- Carbondale7 studies
- Galesburg7 studies
- Waukegan6 studies
- Danville6 studies
- Decatur6 studies
- Champaign6 studies
- Charleston5 studies
- Elgin4 studies
- Naperville4 studies
- Aurora3 studies
- Rockford3 studies
Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial
- University of Illinois, Chicago
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05673148Colonoscopy vs Stool Testing for Older Adults With Colon Polyps
- Northwestern Memorial Hospital, Chicago
Recruiting
Ages 65 to 82 · All sexes · Updated Oct 2, 2026 · NCT05612347A Study to Access Intravenous (IV) Telisotuzumab Adizutecan in Combination With IV Bevacizumab Compared to Standard of Care IV Bevacizumabin Combination With Oral Trifluridine and Tipiracil in Adult Participants With Refractory Metastatic Colorectal Cancer
- University of Chicago Medical Center /ID# 279365, Chicago
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07525206Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
- OSF Saint Anthony's Health Center, Alton
- Rush-Copley Medical Center, Aurora
- Advocate Outpatient Center - Aurora, Aurora
- and 54 more
RecruitingObservational studyHealthy volunteers welcome
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069Family Communications After Genetic Testing
- OSF Saint Anthony's Health Center, Alton
- Advocate Outpatient Center - Aurora, Aurora
- Advocate Good Shepherd Hospital, Barrington
- and 46 more
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07143487Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
- Exelixis Clinical Site #26, Chicago
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05176483Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
- Orchard Healthcare Research Inc.- Skokie, Skokie
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT06324357PRE-ISPY Phase I/II Oncology Platform Program
- The University of Chicago Medicine Comprehensive Cancer Center, Chicago
- UChicago Medicine Comprehensive Cancer Center at Silver Cross Hospital, New Lenox
- UChicago Medicine Orland Park, Orland Park
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT05868226A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer
- University of Chicago Medical Center /ID# 271688, Chicago
- Hope And Healing Cancer Services /ID# 271562, Hinsdale
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT06820463Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
- Illinois Cancer Specialists, Arlington Heights
- Illinois CancerCare - Bloomington, Bloomington
- Illinois Cancer Specialists, Chicago
- and 10 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07222800Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors
- Research Site, Chicago
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06218914A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors
- University of Chicago, Chicago
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06004245A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
- Illinois Cancer Specialists, Arlington Heights
- Illinois CancerCare, Peoria
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06750094Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT Trial
- City of Hope at Chicago, Zion
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07271355A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
- Illinois Cancer Specialists, Arlington Heights
- Illinois CancerCare, Peoria
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06662786Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial
- Northwestern University, Chicago
- University of Chicago Comprehensive Cancer Center, Chicago
- Northwestern Medicine Cancer Center Old Irving Park, Chicago
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT05863195A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
- Local Institution - 0433, Chicago
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07221357Manipulation of the Gut Microbiome by a Standardized Preoperative Diet to Prevent Colorectal Cancer Recurrence and Metastasis Following Surgery
- University of Chicago, Chicago
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT06349590A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
- Sih Cancer Institute, Carterville
- University of Illinois Cancer Center, Chicago
- Alexian Brothers Medical Center, Elk Grove Village
- and 2 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07284849A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
- Illinois Cancer Specialists, Arlington Heights
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT04929223SIBYL: obServation of Therapy Response With lIquid BiopsY evaLuation
- Orchard Healthcare Research Inc., Skokie
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT05935384A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)
- Illinois Cancer Specialists, Arlington Heights
- Illinois CancerCare PC, Peoria
- Springfield Clinic, Springfield
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07549412Clinical Trial of an Anti-cancer Drug, CA-4948 (Emavusertib), in Combination With Chemotherapy Treatment (FOLFOX Plus Bevacizumab) in Metastatic Colorectal Cancer
- Memorial Hospital East, Shiloh
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06696768Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
- Clinical Study Site, Chicago
- Clinical Study Site, Elmhurst
- Clinical Study Site, O'Fallon
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT07228832Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
- Insight Research Institute, Chicago
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06252649Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
- Lurie Children's Hospital-Chicago, Chicago
RecruitingPhase 1/2
12 Months – 30 Years · All sexes · Updated Aug 25, 2026 · NCT04851119A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer
- Research Site, Chicago
RecruitingPhase 2
Ages 18 to 130 · All sexes · Updated Aug 18, 2026 · NCT06792695Minimal Residual Disease Testing for the Early Detection of Cancer Recurrence in Resectable Stage II-IV Colorectal Cancer Patients
- City of Hope at Chicago, Zion
Recruiting
Ages 18 and older · All sexes · Updated Aug 12, 2026 · NCT07125729A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
- Orchard Healthcare Research Inc, Skokie
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06330064A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
- Hope and Healing Cancer Services, Hinsdale
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT04657068Safely Optimizing Body Weight With Mifomelatide (TCMCB07) in Patients With Newly Diagnosed Colorectal Cancer (CRC) or Pancreatic Ductal Adenocarcinoma (PDAC) Undergoing Chemotherapy
- Northwestern University - Robert H. Lurie Comprehensive Cancer Center, Chicago
- Hope and Healing Cancer Services, Hinsdale
- Orchard Healthcare Research, Skokie
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 15, 2026 · NCT06937177A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease
- University of Chicago Medical Center /ID# 274742, Chicago
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT07023289Colorectal Metastasis to Liver Extraction With Auxiliary Transplant and Delayed Resection
- Northwestern University-Comprehensive Transplant Center, Chicago
RecruitingObservational study
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT06698146CARE Tool Study Aim 3
- Alton Memorial Hospital, Alton
Recruiting
Ages 18 and older · All sexes · Updated Jul 8, 2026 · NCT07296887A Trial to Evaluate the Safety and Activity of Fruquintinib in Minority Populations With Advanced, Previously Treated Colorectal Cancer
- Hope and Healing Cancer Services, Hinsdale
RecruitingPhase 4
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT06562543A Study to Investigate ALE.P03 as Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+ Solid Tumors
- The University of Chicago Medical Center - Oncology, Chicago
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Jul 2, 2026 · NCT07169734CT-95 in Advanced Cancers Associated With Mesothelin Expression
- Context Investigational Site, Chicago
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT06756035A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Cancer (FRUITFUL)
- Illinois Cancer Specialists, Arlington Heights
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT07011576BBO-11818 in Adult Subjects With KRAS Mutant Cancer
- OSF Healthcare Cancer Institute, Peoria
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jun 2, 2026 · NCT06917079Exogenous and Endogenous Risk Factors for Early-onset Colorectal Cancer
- Section of Gastroenterology, Hepatology, and Nutrition, Department of Medicine University of Chicago Medicine, Chicago
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 49 · All sexes · Updated Apr 24, 2026 · NCT05732623From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.