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Drug Use and Addiction clinical trials recruiting in the U.S.

169 studies for Drug Use and Addiction are recruiting participants at sites across the United States.

Drugs include prescription and over-the-counter medicines, alcohol, tobacco, and illegal substances. Repeated drug use can change the brain and lead to addiction.

Cities with the most studies

By state

Recently updated studies

Smoking Cessation CM for Veterans With or at Risk for Cancer

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06432985

SMART-r: Substance Monitoring and Active Relapse Tracking Repository

RecruitingObservational study
Ages 18 to 120 · All sexes · Updated Oct 2, 2026 · NCT06676059

Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder

RecruitingObservational studyHealthy volunteers welcome
Ages 21 to 60 · All sexes · Updated Oct 2, 2026 · NCT03745339

Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging

RecruitingHealthy volunteers welcome
Ages 18 to 80 · All sexes · Updated Oct 2, 2026 · NCT01036581

Wakaya: Rising Up for Choctaw Youth Health

RecruitingHealthy volunteers welcome
Ages 12 to 19 · All sexes · Updated Sep 30, 2026 · NCT05818384

Teen Health Choices & Wellness

RecruitingHealthy volunteers welcome
Ages 13 to 16 · All sexes · Updated Sep 29, 2026 · NCT06822569

Shared Decision Making to Treat Or Prevent (STOP) HIV in Criminal Legal Involved Populations (R33)

Recruiting
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07223398

Successful Transitions and Reintegration Tools for Veterans (START-VETS)

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT04366531

DEVELOPMENT OF A NOVEL PEER RECOVERY SUPPORTER TRAINING PLATFORM

Recruiting
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07044531

Evaluation of the Safety and Effects of Psychoactive Substances in People With Past Opioid Use

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 55 · All sexes · Updated Sep 28, 2026 · NCT07218549

tAN for Substance Use Disorder

Recruiting
Ages 18 to 64 · All sexes · Updated Sep 28, 2026 · NCT07281261

rTMS for Craving in Methamphetamine Use Disorder

Recruiting
Ages 18 to 65 · All sexes · Updated Sep 23, 2026 · NCT03470480

A SMART Evaluation of an Adaptive Web-based AUD Treatment for Service Members and Their Partners

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05619185

Safe & Sound Protocol in Adults With Trauma and SUD

Recruiting
Ages 18 to 75 · All sexes · Updated Sep 21, 2026 · NCT07219056

Clinical Decision Support to Increase Use of Medications for Opioid Use Disorder

RecruitingObservational studyHealthy volunteers welcome
Ages 12 to 89 · All sexes · Updated Sep 21, 2026 · NCT06526286

Couples Motivational Interviewing to Reduce Drug Use and HIV Risk in Vulnerable Male Couples

RecruitingHealthy volunteers welcome
Ages 18 to 55 · Men · Updated Sep 17, 2026 · NCT06307977

Recovery Inspired Support Engagement (RISE) Pilot

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07519759

Real-time Opioid Study

Recruiting
Ages 18 to 50 · All sexes · Updated Sep 14, 2026 · NCT07768007

Defining Neurobiological Links Between Substance Use and Mental Illness

RecruitingHealthy volunteers welcome
Ages 18 to 60 · All sexes · Updated Sep 11, 2026 · NCT05538910

Efficacy of a Multi-level School Intervention for LGBTQ Youth

RecruitingHealthy volunteers welcome
Ages 12 to 20 · All sexes · Updated Sep 11, 2026 · NCT05541406

Temporal Interference Methods for Addiction Treatment

RecruitingHealthy volunteers welcome
Ages 21 to 50 · All sexes · Updated Sep 11, 2026 · NCT07210268

Ultrasound Neuromodulation of the Brain for Alcohol Use Disorder

Recruiting
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT06518785

Project SHIELD 2.0: Police Education to Support Public Health in Kentucky

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT07804121

Orexin s Role in the Neurobiology of Substance Use Disorder

RecruitingHealthy volunteers welcome
Ages 18 to 60 · All sexes · Updated Sep 11, 2026 · NCT05630781

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.