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Head and Neck Squamous Cell Carcinoma clinical trials in New Haven, CT

22 studies for Head and Neck Squamous Cell Carcinoma are looking for participants at sites in and around New Haven (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors

RecruitingPhase 1
  • Exelixis Clinical Site #62, New Haven
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05176483

A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

RecruitingPhase 1
  • Smilow Cancer Hospital - Yale New Haven Health, New Haven
  • Yale - New Haven Hospital - Yale Cancer Center, New Haven
  • Smilow Cancer Hospital Phase 1 Unit, New Haven
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07090499

Anti-Ly6E Exatecan ADC M7437 in Advanced Solid Tumors

RecruitingPhase 1
  • Yale University - Yale University School of Medicine, New Haven
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07360314

A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer

RecruitingPhase 3
  • Yale Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07276399

A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Head and Neck Cancer

RecruitingPhase 1/2
  • Yale Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06385080

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

RecruitingPhase 2
  • Smilow Cancer Center/Yale-New Haven Hospital, New Haven
  • Yale University, New Haven
Ages 18 to 79 · All sexes · Updated Sep 22, 2026 · NCT04671667

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

RecruitingPhase 1
  • Yale University, Yale Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05983432

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

RecruitingPhase 2
  • Smilow Cancer Center/Yale-New Haven Hospital, New Haven
  • Yale University, New Haven
  • Yale-New Haven Hospital North Haven Medical Center, North Haven · 7 mi away
  • and 1 more
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT02734537

First in Human Study of TUB-030 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • Yale Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT06657222

ADCE-T02, a Tissue Factor Targeted Antibody-Drug Conjugate, in Patients With Selected Advanced Solid Tumours

RecruitingPhase 1
  • Yale University Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06597721

A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors

RecruitingPhase 1
  • Normunity Investigational Site, New Haven
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07182149

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

RecruitingPhase 2/3
  • Yale University, New Haven
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT04333537

CUE-101with Pembrolizumab for Locally Advanced HPV+HNSCCs

RecruitingPhase 2Healthy volunteers welcome
  • Yale University, New Haven
Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT07172256

A Study to Investigate ALE.P02 as Monotherapy in Adult Patients With Selected CLDN1+ Solid Tumors

RecruitingPhase 1/2
  • Yale Comprehensive Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT06747585

Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • Yale University, Yale Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Jun 23, 2026 · NCT06993844

5-Azacytidine and/or Nivolumab in Resectable HPV-Associated HNSCC

RecruitingPhase 2
  • Yale University, New Haven
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT05317000

Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors

RecruitingPhase 1
  • Yale University School of Medicine /ID# 225707, New Haven
Ages 18 and older · All sexes · Updated Jun 4, 2026 · NCT04777994

A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma

RecruitingPhase 3
  • GSK Investigational Site, New Haven
Ages 18 and older · All sexes · Updated May 26, 2026 · NCT06256588

A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma

RecruitingPhase 3
  • Yale School of Medicine - Smilow Cancer Hospital, New Haven
Ages 18 and older · All sexes · Updated Apr 9, 2026 · NCT06064877

A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

RecruitingPhase 1/2
  • Yale Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Nov 4, 2025 · NCT05902988

Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067

RecruitingPhase 1/2
  • Yale Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Nov 15, 2024 · NCT04787042

Phase II Trial of Neoadjuvant and Adjuvant IO102-IO103 and Pembrolizumab KEYTRUDA® in Patients With Resectable Tumors

RecruitingPhase 2
  • Yale, New Haven
Ages 18 and older · All sexes · Updated Mar 18, 2024 · NCT05280314

Head and Neck Squamous Cell Carcinoma trials in other cities

Other studies in New Haven

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.