A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

RecruitingObservational study

A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients With Hematologic Malignancies and Other Indications

Who can join

All ages · All sexes

Full eligibility criteria

Inclusion Criteria:

* Disorders affecting the hematopoietic system that are inherited, acquired, or result from myeloablative treatment
* Signed informed consent (and signed assent, if applicable) obtained prior to study enrollment
* Pediatric and adult patients of any age

Exclusion Criteria:

* Patients who are receiving only licensed CBUs
* Cord blood transplant recipients at international transplant centers
* Patients who are enrolled on another IND protocol to access the unlicensed CBU(s)
* Patients whose selected unlicensed CBU(s) will be more than minimally manipulated

About the study

This study is an access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs) in pediatric and adult patients with hematologic malignancies and other indications.

What is being tested

A multicenter access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs) (drug)

Sponsor: Center for International Blood and Marrow Transplant Research · Participants: 99,999 · Started: 2011-10

Contact the study team

Official record on ClinicalTrials.gov — NCT01351545

Locations in the U.S.

Alabama	University of Alabama at Birmingham, Birmingham
Arizona	Banner MD Anderson Cancer Center, Gilbert Phoenix Children's Hospital, Phoenix University of Arizona Medical Center - Tucson, Tucson
Arkansas	Arkansas Children's Hospital, Little Rock
California	City of Hope, Duarte Children's Hospital of Los Angeles, Glendale Scripps Green Hospital, La Jolla University of California San Diego, La Jolla Loma Linda University Cancer Center, Loma Linda UCLA, Los Angeles Children's Hospital of Orange County (CHOC), Orange Sutter Medical Center, Sacramento Rady Children's Hospital San Diego, San Diego UCSF (Peds), San Francisco Stanford University Medical Center, Stanford
Colorado	Children's Hospital Colorado, Aurora University of Colorado Hospital, Aurora Presbyterian St. Luke's/Colorado Blood Cancer Institute, Denver
Connecticut	Yale New Haven Hospital, New Haven
Delaware	Nemours - Alfred I. duPont Hospital for Children, Brandywine
District of Columbia	Children's National Medical Center, Washington D.C.
Florida	University of Florida Shands Medical Center, Gainesville Nemours Children's Hospital - Mayo Jacksonville, Jacksonville Niklaus Children's Hospital, Miami University of Miami (peds), Miami AdventHealth Orlando, Orlando Florida Center for Pediatric Cellular Therapy, Orlando Orlando Health Arnold Palmer Hospital for Children, Orlando Orlando Health Cancer Institute Bone Marrow Transplant and Cellular Therapy, Orlando All Children's Hospital, St. Petersburg
Georgia	Children's Healthcare of Atlanta, Atlanta Northside Hospital, Atlanta Georgia Cancer Center at Augusta University Health, Augusta
Hawaii	Kapiolani Medical Center for Women and Children, Honolulu
Illinois	Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago Northwestern Memorial Hospital, Chicago Rush University Medical Center, Chicago University of Chicago, Chicago University of Illinois at Chicago, Chicago Loyola University Medical Center, Maywood
Indiana	Indiana University/Riley Hospital for Children, Indianapolis
Iowa	University of Iowa, Iowa City
Kansas	University of Kansas, Westwood
Kentucky	University of Louisville Hospital - James Brown Cancer Center, Louisville
Louisiana	Children's Hospital of New Orleans/LSUHSC, New Orleans
Maryland	Johns Hopkins, Baltimore Nih/Nhlbi, Bethesda Nih/Niaid, Bethesda
Massachusetts	Beth Israel Deaconess, Boston Dana Farber Cancer Institute, Boston Tufts Medical Center, Boston
Michigan	University of Michigan, Ann Arbor Children's Hospital of Michigan, Detroit Henry Ford Health System, Detroit Helen DeVos Children's Hospital, Grand Rapids Spectrum Health, Grand Rapids
Mississippi	Univeristy of Mississippi Medical Center, Jackson
Missouri	Children's Mercy Hospital and Clinics, Kansas City Cardinal Glennon Children's Medical Center, St Louis Washington University St. Louis, St Louis Washington University/St. Louis Children's Hospital, St Louis
Nebraska	University of Nebraska Medical Center, Omaha
New Jersey	Hackensack University Medical Center, Hackensack Robert Wood Johnson/Cancer Institute of New Jersey, New Brunswick
New York	Roswell Park Cancer Institute, Buffalo North Shore University Hospital, Lake Sucess Cohen Children's Medical Center of New York, New Hyde Columbia University Medical Center - Morgan Stanley Children's Hospital, New York Memorial Sloan-Kettering Cancer Center, New York Mount Sinai Medical Center - New York, New York New York Presbyterian Hospital at Cornell, New York New York University Langone Medical Center, New York Westchester Medical Center, New York Strong Memorial Hospital/University of Rochester, Rochester Stony Brook University Hospital, Stony Brook Children's Hospital at Montefiore, The Bronx
North Carolina	University of North Carolina at Chapel Hill, Chapel Hill Levine Children's Hospital, Charlotte Duke University Medical Center, Durham
Ohio	Childrens Hospital Medical Center of Akron, Akron Cincinnati Children's Hospital, Cincinnati Cleveland Clinic, Cleveland University Hospitals Case Medical Center, Cleveland Nationwide Children's Hospital, Columbus The Arthur G. James Cancer Hospital/The Ohio State University Medical Center, Columbus
Oklahoma	University of Oklahoma Health Science Center, Oklahoma City
Oregon	Oregon Health & Science University/Doernbecher Children's Hospital, Portland
Pennsylvania	Penn State Milton S. Hershey Cancer Center, Hershey Children's Hospital of Philadelphia, Philadelphia Children's Hospital of Pittsburgh, Pittsburgh University of Pennsylvania/Thomas Jefferson, Pittsburgh University of Pittsburgh Medical Center, Pittsburgh West Penn Hospital, Pittsburgh
South Carolina	Medical University of South Carolina, Charleston
South Dakota	Avera Transplant Institute, Sioux Falls
Tennessee	St. Jude Childrens Research Hospital, Memphis Vanderbilt University, Nashville
Texas	Children's Medical Center Dallas, Dallas Medical City Dallas, Dallas Zachary & Elizabeth Fisher Bone Marrow Transplant Program (Brooke Army Medical Center), Fort Sam Houston Cook Children's Hospital, Fort Worth M.D. Anderson Cancer Center, Houston Texas Children's Hospital - Baylor Medical Center, Houston Methodist Healthcare System of San Antonio/Texas Transplant Institute, San Antonio The Children's Hospital of San Antonio, San Antonio
Utah	University of Utah, Salt Lake City
Virginia	University of Virginia, Charlottesville Virginia Commonwealth University, Richmond
Washington	Fred Hutchinson Cancer Research Center, Seattle
West Virginia	West Virginia University, Morgantown
Wisconsin	University of Wisconsin - Madison, Madison Children's Hospital of Wisconsin, Milwaukee

Conditions

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.