Home › Type 2 Diabetes › NCT05165706
Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance
Who can join
Ages 35 to 65 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Age 35-65 * BMI 25-35 kg/m2 * Stable body weight * Nondiabetic Exclusion Criteria: Patients with; * diabetes * major organ disease * history of liposuction or bariatric surgery * active eating or psychiatric disorder * pregnancy or lactation, heavy alcohol use * recent change in weight (over the past 12 weeks) * use of weight loss medication, statins, or oral steroids Clinical screening exclusions; * hematocrit \< 33% * fasting glucose \>/= 126 mg/dL * blood pressure \>160/100 mmHg
About the study
This 12-week controlled diet and weight intervention study seeks to define the molecular pathways that link excess body weight to the development of insulin resistance (IR). Blood, adipose and stool are sampled at three timepoints; baseline, peak weight (4 weeks) and post weight loss to monitor changes in cellular processes. Additionally, direct insulin sensitivity testing, and radiological measurement of visceral fat and intrahepatic fat content is measured at three timepoints to correlate clinical indices with cellular changes.
What is being tested
- Dietary Intervention Mediterranean Low Carbohydrate Diet (behavioral)
- Dietary Intervention Standard Low Carbohydrate Diet (behavioral)
- Dietary Intervention Standard Low Fat Diet (behavioral)
Sponsor: Stanford University · Participants: 110 · Started: Jan 31, 2019
Contact the study team
- Ekrem M Ayhan, BS · Phone: 908-619-5381
Official record on ClinicalTrials.gov — NCT05165706
Locations in the U.S.
| California | Stanford University, Stanford |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.