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Combined Transcranial Magnetic Stimulation and Therapy for MTBI Related Headaches

Combined Nonpharmacological Therapies for MTBI-Related Headaches

Who can join

Ages 18 to 65 · All sexes

Inclusion Criteria:

1. Mild Traumatic Brain Injury (mTBI)
2. Chronic headaches \> 3 months after injury
3. Aged 18-65
4. No prior TMS treatment
5. Persistent Headaches with an intensity \> 30 / 100
6. No history of daily headache prior to mTBI

Exclusion Criteria:

1. Pregnant
2. Pacemaker or any metal in body that would prevent MRI
3. History of dementia or major psychiatric disease, such as bipolar disorder or schizophrenia
4. Presence of any other chronic neuropathic pain states
5. History of seizure
6. Pending litigation
7. Can't understand English
8. History of chronic headache like migraine prior to mTBI
9. Evidence in chart of exacerbation of depressive/anxiety symptoms, active substance dependence, suicidal intent or attempt within previous month

About the study

This study will assess the combined effectiveness of repetitive transcranial magnetic stimulation (rTMS) and telehealth based therapy in helping manage mild traumatic brain injury (mTBI) related headaches. The investigators hypothesize that active rTMS combined with telehealth therapy will provide marked reduction in mTBI related headaches and symptoms in comparison to their placebo counterparts.

What is being tested

• Active rTMS (device)
• Headache Management Therapy (behavioral)
• Sham rTMS (device)
• Headache Education Control (behavioral)

Sponsor: Veterans Medical Research Foundation · Participants: 240 · Started: Jan 1, 2022

Contact the study team

• Caleb Lopez, BS · Phone: 858-552-8585

Official record on ClinicalTrials.gov — NCT05176392

Locations in the U.S.

Conditions

• Traumatic Brain Injury
• Headache
• Depression

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.