Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * being 18 years or older * meeting DSM-V criteria for opioid dependence and being newly prescribed and adherent to Medication for Opioid Use Disorder (e.g., methadone, buprenorphine) at the APT Foundation, Inc. * showing mild cognitive impairment based on the Montreal Cognitive Assessment (MoCA) screening * having initiated Pre-Exposure Prophylaxis (PrEP) within the past week * confirming HIV-negative status through proof of PrEP prescription * reporting unsafe injection drug use practices or unprotected sex within the past 3 months * having a cell phone * being able to read and understand in English Exclusion Criteria: * unable to provide consent * actively suicidal * actively homicidal * actively psychotic * display MoCA scores suggestive of dementia
About the study
The investigators will conduct an optimization trial among N=256 PWID newly started on medication for opioid use disorder and Pre-Exposure Prophylaxis (PrEP) to assess the performance of four intervention components (Attention, Executive Functioning, Memory, and Information Processing) aimed at enhancing the ability of PWID on MOUD to process and utilize HIV prevention content, leading to improvements in HIV prevention information, motivation, behavioral skills, and behaviors (IMB).
What is being tested
- community-friendly health recovery program (behavioral)
- Pre-Exposure Prophylaxis and Post-Exposure Prophylaxis (drug)
Sponsor: University of Connecticut · Participants: 256 · Started: Mar 1, 2023
Contact the study team
- Brian Sibilio, BS · Phone: 2037814690
- Tanya Adler, MS · Phone: 2037814690
Official record on ClinicalTrials.gov — NCT05669534
Locations in the U.S.
| Connecticut | APT Foundation, New Haven |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.