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Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog

Recruiting

Pilot Study to Investigate Possible Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Inclusion criteria:

* English speaking
* Diagnosis of Long COVID

Exclusion criteria:

* Any history of:

  * Coronary artery dissection or aortic dissection
  * Neurological disease (e.g. dementia, Alzheimer's disease, or other brain-related disease)
  * Cerebrovascular disease or stroke
  * Aneurysm
* If currently has:

  * Moderate-severe chronic obstructive pulmonary disease
  * Uncontrolled moderate-severe asthma
  * Moderate-severe bronchiectasis
  * Moderate-severe interstitial lung disease, requiring the use of supplemental oxygen
  * A necessity to use supplemental oxygen, for any reason
  * New or worsening symptoms (decompensation) of heart failure
  * Right heart disease due to chronic pulmonary disease/sleep apnea
  * Uncontrolled myocardial ischemia or angina
  * Uncontrolled heart arrhythmias
  * Heart or lung infection (e.g. myocarditis or pericarditis)
  * Left main coronary artery stenosis
  * Moderate-severe aortic stenosis
  * Pulmonary embolism, pulmonary infarction, or other blood clots
  * Severe respiratory disease
  * Chronic kidney disease
  * Chronic liver disease
* Females of childbearing potential will complete a urine pregnancy test at their baseline visit to rule out pregnancy
* BMI \>40
* Study staff unable to obtain adequate signal for cerebral blood flow

About the study

This study aims to assess the effects of both acute and chronic exposures to hypoxia and hypercapnia in patients with Long COVID syndrome.

What is being tested

Sponsor: Mayo Clinic · Participants: 45 · Started: Sep 24, 2024

Contact the study team

Official record on ClinicalTrials.gov — NCT06614309

Locations in the U.S.

ArizonaMayo Clinic in Arizona, Scottsdale

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.