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Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog
Recruiting
Pilot Study to Investigate Possible Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion criteria: * English speaking * Diagnosis of Long COVID Exclusion criteria: * Any history of: * Coronary artery dissection or aortic dissection * Neurological disease (e.g. dementia, Alzheimer's disease, or other brain-related disease) * Cerebrovascular disease or stroke * Aneurysm * If currently has: * Moderate-severe chronic obstructive pulmonary disease * Uncontrolled moderate-severe asthma * Moderate-severe bronchiectasis * Moderate-severe interstitial lung disease, requiring the use of supplemental oxygen * A necessity to use supplemental oxygen, for any reason * New or worsening symptoms (decompensation) of heart failure * Right heart disease due to chronic pulmonary disease/sleep apnea * Uncontrolled myocardial ischemia or angina * Uncontrolled heart arrhythmias * Heart or lung infection (e.g. myocarditis or pericarditis) * Left main coronary artery stenosis * Moderate-severe aortic stenosis * Pulmonary embolism, pulmonary infarction, or other blood clots * Severe respiratory disease * Chronic kidney disease * Chronic liver disease * Females of childbearing potential will complete a urine pregnancy test at their baseline visit to rule out pregnancy * BMI \>40 * Study staff unable to obtain adequate signal for cerebral blood flow
About the study
This study aims to assess the effects of both acute and chronic exposures to hypoxia and hypercapnia in patients with Long COVID syndrome.
What is being tested
- Acute Placebo Visit (other)
- Acute Progressive Carbon Dioxide (other)
- Acute Intermittent Hypoxia (other)
- Training: Progressive Carbon Dioxide Ramping (other)
- Training: Intermittent Hypoxic Exposure (other)
- Training: Placebo Control (other)
Sponsor: Mayo Clinic · Participants: 45 · Started: Sep 24, 2024
Contact the study team
- Jordan Parks · Phone: 480-301-6616
Official record on ClinicalTrials.gov — NCT06614309
Locations in the U.S.
| Arizona | Mayo Clinic in Arizona, Scottsdale |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.