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Rectal Cancer clinical trials recruiting in the U.S.
75 studies for Rectal Cancer are recruiting participants at sites across the United States.
Cities with the most studies
- New York City, NY17 studies
- Boston, MA12 studies
- Houston, TX11 studies
- Los Angeles, CA10 studies
- St. Louis, MO10 studies
- Chicago, IL10 studies
- Columbus, OH9 studies
- Seattle, WA9 studies
- Tampa, FL9 studies
- Aurora, CO8 studies
- Nashville, TN8 studies
- Philadelphia, PA8 studies
- Edison, NJ8 studies
- Rochester, MN8 studies
- Baldwin Park, CA8 studies
- Salt Lake City, UT7 studies
- Portland, OR7 studies
- Milwaukee, WI7 studies
- San Antonio, TX7 studies
- Omaha, NE7 studies
- Sacramento, CA6 studies
- Cincinnati, OH6 studies
- Phoenix, AZ6 studies
- Queens, NY6 studies
- New Orleans, LA6 studies
- San Diego, CA6 studies
- Staten Island, NY6 studies
- Fargo, ND6 studies
- New Rochelle, NY6 studies
- Grand Rapids, MI6 studies
- Denver, CO5 studies
- Lexington, KY5 studies
- Allentown, PA5 studies
- Billings, MT5 studies
- Arlington, VA5 studies
- Pittsburgh, PA5 studies
- Atlanta, GA5 studies
- Baltimore, MD5 studies
- Kansas City, MO5 studies
- Durham, NC5 studies
By state
- Alabama5 studies
- Alaska3 studies
- Arizona11 studies
- Arkansas4 studies
- California22 studies
- Colorado15 studies
- Connecticut5 studies
- Delaware3 studies
- Florida18 studies
- Georgia8 studies
- Idaho5 studies
- Illinois13 studies
- Indiana6 studies
- Iowa5 studies
- Kansas6 studies
- Kentucky5 studies
- Louisiana7 studies
- Maine3 studies
- Maryland9 studies
- Massachusetts15 studies
- Michigan10 studies
- Minnesota14 studies
- Mississippi3 studies
- Missouri13 studies
- Montana6 studies
- Nebraska7 studies
- Nevada4 studies
- New Jersey12 studies
- New Mexico5 studies
- New York22 studies
- North Carolina11 studies
- North Dakota6 studies
- Ohio17 studies
- Oklahoma5 studies
- Oregon8 studies
- Pennsylvania15 studies
- South Carolina4 studies
- South Dakota4 studies
- Tennessee10 studies
- Texas18 studies
- Utah8 studies
- Virginia11 studies
- Washington9 studies
- West Virginia3 studies
- Wisconsin11 studies
- Wyoming3 studies
Recently updated studies
A Study of Tucatinib and Trastuzumab in People With Rectal Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT05672524A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06997497Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes
Recruiting
Ages 18 to 99 · All sexes · Updated Nov 12, 2026 · NCT04907643A Phase 1 Dose Escalation and Dose Expansion Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07458347Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT04703101Gemcitabine, Cisplatin, Nab-paclitaxel (GAP) and Cemiplimab for Locally Advanced Biliary Tract Cancer (BTC)
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07433673Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07283939Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps
Recruiting
Ages 45 to 70 · All sexes · Updated Nov 4, 2026 · NCT05080673Distance-Based Exercise to Preserve Function and Prevent Disability
Recruiting
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07059884Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT04165772RECTIFY-1: Neoadjuvant Botensilimab + Balstilimab in MSS/pMMR Early Rectal Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07735624Family Communications After Genetic Testing
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07143487Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients
RecruitingPhase 1/2
Ages 18 to 72 · All sexes · Updated Nov 3, 2026 · NCT03190941Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant Disease
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 20, 2026 · NCT06607458Neoadjuvant Botensilimab and Balstilimab for the Treatment of Advanced Resectable Colorectal Cancer NEST3
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 19, 2026 · NCT07595874Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 15, 2026 · NCT06239194An Informational and Supportive Care Intervention for Patients With Locally Advanced Rectal Cancer
Recruiting
Ages 18 and older · All sexes · Updated Oct 9, 2026 · NCT05914766A Bowel Management Program (Retrograde Rectal Enema) for the Treatment of Low Anterior Resection Syndrome in Rectal Cancer Patients
Recruiting
Ages 18 and older · All sexes · Updated Oct 6, 2026 · NCT06424522Trial Utilizing Metronidazole to Optimize the Microbiome of Rectal Adenocarcinoma Undergoing Neoadjuvant Therapy
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 6, 2026 · NCT06569368Trial of the Efficacy and Safety of Short and Long Course Radiation Therapy With/Without BMX-001
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT05254327PRE-ISPY Phase I/II Oncology Platform Program
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT05868226The Impact of PReOPerative Exercise and NutritionaL Optimization on Perioperative Outcomes for Patients Undergoing Treatment for Rectal Cancer: The PROPEL Trial
Recruiting
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT06565052Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06128551A Study of Botensilimab and Balstilimab for Colorectal Cancer With ctDNA+ After Surgery and Chemotherapy
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07227636A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07629960From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.