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Rectal Cancer clinical trials recruiting in the U.S.
79 studies for Rectal Cancer are recruiting participants at sites across the United States.
Cities with the most studies
- New York City, NY17 studies
- Boston, MA12 studies
- Houston, TX11 studies
- St. Louis, MO11 studies
- Columbus, OH10 studies
- Los Angeles, CA10 studies
- Tampa, FL9 studies
- Seattle, WA9 studies
- Nashville, TN9 studies
- Baldwin Park, CA8 studies
- Philadelphia, PA8 studies
- Rochester, MN8 studies
- Edison, NJ8 studies
- Salt Lake City, UT8 studies
- Aurora, CO8 studies
- Omaha, NE7 studies
- Chicago, IL7 studies
- San Antonio, TX7 studies
- Portland, OR7 studies
- Fargo, ND6 studies
- Phoenix, AZ6 studies
- Queens, NY6 studies
- Staten Island, NY6 studies
- New Rochelle, NY6 studies
- Grand Rapids, MI6 studies
- Detroit, MI6 studies
- San Diego, CA6 studies
- Kansas City, MO5 studies
- Duluth, MN5 studies
- East Norwalk, CT5 studies
- Greenburgh, NY5 studies
- Denver, CO5 studies
- Lexington, KY5 studies
- Milwaukee, WI5 studies
- Cincinnati, OH5 studies
- Atlanta, GA5 studies
- New Orleans, LA5 studies
- Sacramento, CA5 studies
- Pittsburgh, PA5 studies
- Allentown, PA5 studies
By state
- Alabama4 studies
- Alaska3 studies
- Arizona11 studies
- Arkansas4 studies
- California22 studies
- Colorado15 studies
- Connecticut5 studies
- Delaware3 studies
- Florida19 studies
- Georgia8 studies
- Idaho5 studies
- Illinois12 studies
- Indiana5 studies
- Iowa4 studies
- Kansas6 studies
- Kentucky5 studies
- Louisiana6 studies
- Maine3 studies
- Maryland9 studies
- Massachusetts15 studies
- Michigan11 studies
- Minnesota14 studies
- Mississippi3 studies
- Missouri14 studies
- Montana6 studies
- Nebraska7 studies
- Nevada4 studies
- New Jersey13 studies
- New Mexico5 studies
- New York21 studies
- North Carolina10 studies
- North Dakota6 studies
- Ohio18 studies
- Oklahoma5 studies
- Oregon8 studies
- Pennsylvania15 studies
- South Carolina5 studies
- South Dakota4 studies
- Tennessee11 studies
- Texas18 studies
- Utah9 studies
- Virginia10 studies
- Washington9 studies
- West Virginia3 studies
- Wisconsin10 studies
- Wyoming3 studies
Recently updated studies
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT06997497Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06128551A Study of Botensilimab and Balstilimab for Colorectal Cancer With ctDNA+ After Surgery and Chemotherapy
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07227636A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07629960Establishing a ctDNA Biomarker to Improve Organ Preserving Strategies in Patients With Rectal Cancer
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT05081024A Study to Investigate the Safety and Preliminary Efficacy of GSK5460025 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT07213609Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT04165772EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.
Recruiting
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT06263088Evaluating Novel Therapies in ctDNA Positive GI Cancers
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT05482516ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT05059444Resilience and Equity in Aging, Cancer, and Health (REACH)
Recruiting
Ages 65 and older · All sexes · Updated Sep 10, 2026 · NCT04674267PRE-ISPY Phase I/II Oncology Platform Program
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT05868226Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women
RecruitingObservational study
Ages 18 to 50 · Women · Updated Sep 2, 2026 · NCT06904365Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT07283939Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
RecruitingPhase 2
Ages 18 to 100 · All sexes · Updated Sep 2, 2026 · NCT07292298Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps
Recruiting
Ages 45 to 70 · All sexes · Updated Sep 2, 2026 · NCT05080673Family Communications After Genetic Testing
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT07143487Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal Resections
Recruiting
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT07351071Evaluation of Quality of Life and Utilities Following Surgical Treatment of Stage I-IV Rectal Cancer
RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 31, 2026 · NCT02107105Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients
RecruitingPhase 1/2
Ages 18 to 72 · All sexes · Updated Aug 24, 2026 · NCT03190941ColoSeal™ ICD System Anastomotic Protection Pivotal Study
Recruiting
Ages 22 to 75 · All sexes · Updated Aug 21, 2026 · NCT07429110Trial of the Efficacy and Safety of Short and Long Course Radiation Therapy With/Without BMX-001
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT05254327RECTIFY-1: Neoadjuvant Botensilimab + Balstilimab in MSS/pMMR Early Rectal Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07735624Distance-Based Exercise to Preserve Function and Prevent Disability
Recruiting
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT07059884A Phase I-II Study to Test the Safety and Efficacy of PD1 (AB122) and Adenosine Receptor (AB928) Antagonists With Chemotherapy After Short-Course Radiation for Rectal Cancer.
RecruitingPhase 2
Ages 18 to 90 · All sexes · Updated Jul 29, 2026 · NCT05024097From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.