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Implementation of an Algorithm- and Multi-professional Team-supported Strategy to Improve Lipid Management of Patients With Atherosclerotic Cardiovascular Disease

Implementation of an Algorithm- and Multi-professional Team-supported Strategy to Improve Lipid Management of Patients With Atherosclerotic Cardiovascular Disease: OPTIMIZE ASCVD

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Provided informed consent
* Age \>18 years inclusive at screening
* Documented atherosclerotic vascular disease including:

  * Coronary artery disease (prior revascularization, myocardial infarction, imaging evidence of coronary atherosclerosis)
  * Peripheral artery disease (prior revascularization, amputation, ankle: brachial index (ABI) ≤ 0.90, imaging evidence of extra-coronary atherosclerosis)
  * Carotid artery disease (prior endarterectomy or stenting of the extracranial carotid artery or imaging evidence of carotid atherosclerosis)
  * Imaging evidence of atherosclerotic vascular disease in a non-coronary vascular bed (e.g. aorta, mesenteric, renal)
  * LDL-C \>70mg/dL

Exclusion Criteria:

* Any reason that, in the opinion of the investigator, the patient would be unable to adhere to the protocol for the duration of the study (e.g. terminal diagnosis, metastatic cancer) or in whom participation might result in harm.
* Planned active titration of current lipid-lowering therapy
* Myocardial infarction or arterial revascularization within prior 30 days

About the study

This is a randomized, controlled, collaborative, multicenter, pilot implementation science study evaluating the hypothesis that algorithm- and multi-professional team-supported lipid management reduces low density lipoprotein-cholesterol (LDL-C) compared with usual care in patients with atherosclerotic cardiovascular disease (ASCVD).

What is being tested

• Algorithm- and multi-professional team-supported lipid management (other)
• Guideline-directed lipid management by usual care provider (other)

Sponsor: Colorado Prevention Center · Participants: 100 · Started: Dec 10, 2025

Contact the study team

• Marc Bonaca, MD · Phone: (303) 860-9900
• Sivan Naveh, MD. RPV · Phone: 720-848-5300

Official record on ClinicalTrials.gov — NCT07334834

Locations in the U.S.

Conditions

• Hyperlipidemias
• Atherosclerosis
• Coronary Artery Disease
• Peripheral Arterial Disease
• Carotid Artery Disease

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.