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Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain

RecruitingObservational study

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

* Diagnosis of chronic pain (generally pain duration of at least 3-6 months) localized to an anatomical region appropriate for cryoneurolysis as determined by the treating physician.
* Planned cryoneurolysis procedure as part of standard clinical care.
* Ability to provide written informed consent.
* Ability and willingness to complete baseline and follow-up questionnaires.

Exclusion Criteria:

* Cryoneurolysis performed as part of a separate investigational trial in which data sharing is not permitted.
* Active infection or other clinical contraindication to the procedure as determined by the treating clinician.
* Life expectancy of less than 12 months in the judgment of the treating clinician.
* Any condition that, in the investigator's opinion, would interfere with study participation or completion of follow-up, such as severe psychiatric instability or active substance use that precludes reliable follow-up

About the study

To prospectively describe patient-centered and health utilization outcomes through 12 months after cryoneurolysis performed as routine clinical care for chronic pain at Yale.

Sponsor: Yale University · Participants: 80 · Started: Jun 20, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07639060

Locations in the U.S.

ConnecticutYale New Haven Health Old Saybrook Medical Center, Old Saybrook

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.