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Non-Invasive Low Intensity Focused Ultrasound Stimulation for Drug-Resistant Epilepsy

Recruiting

Pilot Study of Non-Invasive Low Intensity Focused Ultrasound as an Adjunctive Treatment for Drug-Resistant Epilepsy

Who can join

Ages 21 to 65 · All sexes

Full eligibility criteria
Inclusion Criteria

* Male or female between 21 and 65 years of age at screening
* Clinical diagnosis of drug-resistant epilepsy with on average, 4 or more seizures per month.
* Able to provide informed consent (or assent when applicable) by the subject or subject's legal representative.
* Be willing to undergo a brain MRI.
* Be able and willing to wear a headband during the treatment duration.
* Be able to complete scheduled visits and daily seizure logs.

Exclusion Criteria

* Has a craniotomy or pathologic intracranial lesion (e.g. vascular malformations) in the trajectory of the focused ultrasound beam.
* Pregnant, breastfeeding, is attempting pregnancy, or unwilling to practice birth control during participation in the study.
* Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data.
* Has any unstable medical or psychiatric disease.
* Any contraindications for completing a brain MRI scan.
* Has evidence of any other clinically relevant neurological disorder at the time of screening, including Alzheimer's disease, frontotemporal dementia, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis.

About the study

The goal of this study is to investigate the effects of a non-invasive, low intensity focused ultrasound (LIFU) stimulation on seizure frequency and the epileptogenic network in drug-resistant epilepsy. LIFU uses focused sound waves to modulate deep brain regions and to enable changes in brain network activity. Encephalography (EEG) and behavioral tasks will also be used to study how LIFU affects brain activity.

What is being tested

Sponsor: University of California, San Francisco · Participants: 40 · Started: Jul 9, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT07680842

Locations in the U.S.

CaliforniaUniversity of California, San Francisco, San Francisco

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.