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Breast Cancer clinical trials in Birmingham, AL

24 studies for Breast Cancer are looking for participants at sites in and around Birmingham (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

RecruitingPhase 2
  • UAB O'Neal Comprehensive Cancer Center - The Kirklin Clinic of UAB Hospital, Birmingham
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06760819

Phase IIIb Study of Ribociclib + ET in Early Breast Cancer

RecruitingPhase 3
  • Central Alabama Research, Birmingham
Ages 18 to 100 · All sexes · Updated Oct 2, 2026 · NCT05827081

A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer

RecruitingPhase 2
  • Alabama Oncology, Birmingham
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06369285

PRE-ISPY Phase I/II Oncology Platform Program

RecruitingPhase 1/2
  • The University of Alabama at Birmingham O'Neal Comprehensive Cancer Center, Birmingham
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT05868226

Phase II Single Arm Trial of Low Dose Capecitabine in Patients With Advanced Breast Cancer

RecruitingPhase 2
  • University of Alabama at Birmingham, Birmingham
Ages 60 and older · Women · Updated Sep 30, 2026 · NCT06105684

An Investigational Study of BG-75202 Alone and in Combination With Other Therapeutic Agents in Adults With Advanced Solid Tumors

RecruitingPhase 1
  • University of Alabama At Birmingham Hospital, Birmingham
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07222267

Improved Successful Retrieval Rate of HydroMARK Plus Breast Biopsy Site Marker in Comparison to HydroMARK as Well as Improved Surgeon Satisfaction

Recruiting
  • The Kirklin Clinic, Birmingham
Ages 18 to 90 · Women · Updated Sep 25, 2026 · NCT06294574

A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • University of Alabama at Birmingham, Birmingham
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT06618287

A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer

RecruitingPhase 2
  • University of Alabama at Birmingham, Birmingham
Ages 18 and older · Women · Updated Sep 22, 2026 · NCT07287098

Women Informed to Screen Depending on Measures of Risk (Wisdom Study)

RecruitingHealthy volunteers welcome
  • University of Alabama at Birmingham, Birmingham
Ages 30 to 74 · Women · Updated Sep 21, 2026 · NCT02620852

Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

RecruitingPhase 1
  • University of Alabama Birmingham, Birmingham
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06293898

Evaluating Minimal Residual Disease (MRD) Through Longitudinal Circulating Tumor DNA (ctDNA) Profiling in Breast Malignancies

RecruitingObservational study
  • Birmingham Hematology Associates, Birmingham
Ages 18 to 99 · All sexes · Updated Sep 3, 2026 · NCT07211178

TReatment of ADC-Refractory Breast CancEr With Dato-DXd or T-DXd: TRADE DXd

RecruitingPhase 2
  • University of Alabama, Birmingham
Ages 18 and older · All sexes · Updated Aug 26, 2026 · NCT06533826

Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breasts

RecruitingHealthy volunteers welcome
  • University of Alabama, Birmingham, Birmingham
Ages 45 to 74 · Women · Updated Jul 31, 2026 · NCT05625659

Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers

RecruitingPhase 1
  • Uni of Alabama at Birmingham, Birmingham
Ages 18 to 100 · All sexes · Updated Jul 29, 2026 · NCT06562192

Promoting Resilience in Women With Breast Cancer (PRISM -MBC)

Recruiting
  • The University of Alabama, Birmingham
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT06855654

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

RecruitingPhase 2
  • University of Alabama at Birmingham, Birmingham
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT01042379

Comparative Effectiveness Trial of Two Supportive Cancer Care Delivery Models for Adults With Cancer

Recruiting
  • University of Alabama at Birmingham, Birmingham
Ages 18 and older · All sexes · Updated Apr 30, 2026 · NCT05297734

A Study of Enzalutamide, Enzalutamide in Combination With Mifepristone, or Chemotherapy in People With Metastatic Breast Cancer

RecruitingPhase 2
  • University of Alabama at Birmingham, Birmingham
Ages 18 and older · All sexes · Updated Feb 25, 2026 · NCT06099769

Positron Emission Tomography (PET) Imaging With Zirconium-89 (89Zr)-Trastuzumab for Prediction of HER2 Targeted Therapy Effectiveness

RecruitingEarly phase 1
  • The Kirklin Clinic, Birmingham
Ages 18 and older · Women · Updated Jan 26, 2026 · NCT03321045

Gene Signatures to Guide HR+MBC Therapy in a Diverse Cohort

RecruitingPhase 2
  • University of Alabama Birmingham, Birmingham
Ages 18 and older · All sexes · Updated Jan 20, 2026 · NCT05693766

Time-Restricted Eating and Cancer: Clinical Outcomes, Mechanisms, and Moderators

Recruiting
  • The University of Alabama at Birmingham, Birmingham
Ages 18 and older · All sexes · Updated Dec 16, 2025 · NCT04722341

RAD 1802: Pilot Trial of Five Fraction Stereotactic Body Radiotherapy for Early Stage Breast Cancer Patients Eligible for Post-Operative Accelerated Partial Breast Irradiation (APBI)

Recruiting
  • University of Alabama at Birmingham (UAB) Hazelrig-Salter Radiation Oncology Center (HSROC), Birmingham
Ages 18 to 99 · All sexes · Updated Oct 31, 2025 · NCT03643861

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Birmingham
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

About Breast Cancer

Breast cancer is a cancer that starts in the breast tissue, when cells change and grow out of control. These extra cells can form a mass called a tumor.

More about Breast Cancer on MedlinePlus

Breast Cancer trials in other cities

Other studies in Birmingham

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.