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Pain clinical trials recruiting in the U.S.
207 studies for Pain are recruiting participants at sites across the United States.
Pain is a feeling triggered in the nervous system. You may feel it as a prick, tingle, sting, burn, or ache. Read about the causes and what can help.
Cities with the most studies
- Durham, NC15 studies
- Washington, DC15 studies
- Boston, MA14 studies
- New York City, NY11 studies
- Houston, TX10 studies
- Los Angeles, CA9 studies
- New Haven, CT9 studies
- Salt Lake City, UT9 studies
- Pittsburgh, PA9 studies
- San Diego, CA9 studies
- Baltimore, MD8 studies
- Seattle, WA7 studies
- Atlanta, GA7 studies
- Gainesville, FL6 studies
- Chicago, IL6 studies
- St. Louis, MO5 studies
- Cincinnati, OH5 studies
- Greenburgh, NY5 studies
- Indianapolis, IN5 studies
- Charlottesville, VA4 studies
- Edison, NJ4 studies
- Ann Arbor, MI4 studies
- Mountain View, CA4 studies
- Birmingham, AL4 studies
- San Antonio, TX4 studies
- Staten Island, NY4 studies
- Charleston, SC4 studies
- New Rochelle, NY4 studies
- Tallahassee, FL4 studies
- Minneapolis, MN4 studies
- Cleveland, OH3 studies
- Austin, TX3 studies
- Miami, FL3 studies
- Aurora, CO3 studies
- Phoenix, AZ3 studies
- Orlando, FL3 studies
- Rochester, NY3 studies
- San Francisco, CA3 studies
- Philadelphia, PA3 studies
- Nashville, TN3 studies
By state
- Alabama6 studies
- Arizona3 studies
- California30 studies
- Colorado7 studies
- Connecticut10 studies
- District of Columbia9 studies
- Florida21 studies
- Georgia11 studies
- Illinois10 studies
- Indiana5 studies
- Kansas3 studies
- Maryland15 studies
- Massachusetts16 studies
- Michigan6 studies
- Minnesota5 studies
- Missouri4 studies
- New Jersey10 studies
- New York24 studies
- North Carolina20 studies
- Ohio11 studies
- Oklahoma3 studies
- Oregon4 studies
- Pennsylvania14 studies
- South Carolina5 studies
- Tennessee6 studies
- Texas17 studies
- Utah9 studies
- Virginia9 studies
- Washington9 studies
- Wisconsin4 studies
Recently updated studies
Virtual Walking Therapy for Neuropathic Pain Following Incomplete Spinal Cord Injury
Recruiting
Ages 18 and older ยท All sexes ยท Updated Oct 5, 2026 ยท NCT06330181taVNS in Veterans With Knee OA (AVAHCS)
Recruiting
Ages 45 to 75 ยท All sexes ยท Updated Oct 5, 2026 ยท NCT07804199Randomized Controlled Trial of the STEIN Protocol: A Neuroplastic Pain Education and Guided Breathing Intervention During Awake Cataract Surgery
Recruiting
All ages ยท All sexes ยท Updated Oct 2, 2026 ยท NCT07715591Sociocultural & Biobehavioral Influences on Pain Expression and Assessment
RecruitingHealthy volunteers welcome
Ages 18 to 60 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT03258580State-dependent Interoception, Value-based Decision-making, and Introspection
RecruitingHealthy volunteers welcome
Ages 18 to 55 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT05666726Neural and Psychological Mechanisms of Pain Perception
RecruitingHealthy volunteers welcome
Ages 18 to 50 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT02446262Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery
RecruitingPhase 1Healthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Oct 2, 2026 ยท NCT06767566Home-based Rehabilitation Intervention for Phantom Limb Pain in Veterans With Lower Limb Amputations
Recruiting
Ages 18 to 89 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT06106984Binaural Beats for Postoperative Pain and Anxiety Reduction
Recruiting
Ages 18 to 99 ยท All sexes ยท Updated Sep 30, 2026 ยท NCT07437469An Open-Label, Safety and Efficacy Study of Cebranopadol in Participants With Acute Pain With Surgical or Non-Surgical Origin
RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Sep 30, 2026 ยท NCT07845071Feasibility of a Mindfulness Intervention for Endometriosis Surgery
Recruiting
Ages 18 and older ยท Women ยท Updated Sep 29, 2026 ยท NCT06141720Behavioral Economic & Staffing Strategies in the ICU
Recruiting
Ages 19 and older ยท All sexes ยท Updated Sep 29, 2026 ยท NCT06184945Pain and Smoking Study 2.0: A Randomized Clinical Trial of Smoking Cessation Among Veterans With Chronic Pain
Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 29, 2026 ยท NCT06442514Chronic Postsurgical Pain
RecruitingObservational study
Ages 5 to 17 ยท All sexes ยท Updated Sep 25, 2026 ยท NCT05764681Enhanced Pain Coping in Cancer (EPIC): A Study of Managing Treatment-Related Joint Pain in Breast Cancer Survivors
RecruitingPhase 2
Ages 18 and older ยท Women ยท Updated Sep 22, 2026 ยท NCT06728579Transcutaneous Electrical Nerve Stimulation for Pain Mitigation During Intrauterine Device Placement
Recruiting
Ages 18 and older ยท Women ยท Updated Sep 18, 2026 ยท NCT06991075Functional Neuroimaging to Detect the Neural Signatures of the Unpleasantness of Pain and Effort
RecruitingEarly phase 1
Ages 18 to 50 ยท All sexes ยท Updated Sep 18, 2026 ยท NCT06472622Feasibility Study of a Guided Imagery Therapy Mobile Application for Functional Abdominal Pain Disorders in Children
Recruiting
Ages 7 to 12 ยท All sexes ยท Updated Sep 17, 2026 ยท NCT07222943Transcutaneous Vagus Nerve Stimulation in SLE
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 17, 2026 ยท NCT06987565Impact of Art Therapy on Self-Reported Pain and Anxiety Scores of Patients Waiting to Be Seen in the Emergency Department
RecruitingHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Sep 17, 2026 ยท NCT05540106Clinical and Scientific Assessment of Pain and Painful Disorders
RecruitingObservational studyHealthy volunteers welcome
Ages 12 to 120 ยท All sexes ยท Updated Sep 16, 2026 ยท NCT02707029Transdiagnostic Cognitive Biomarkers
RecruitingHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Sep 15, 2026 ยท NCT04864080Brief Mindfulness Intervention for Pain Before an In-clinic Orthopedic Procedure
Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 15, 2026 ยท NCT06471075Nebulized Ketamine to Nebulized Fentanyl for Treating Acute Painful Conditions in the ED
RecruitingPhase 4
Ages 18 to 120 ยท All sexes ยท Updated Sep 15, 2026 ยท NCT06364540Vagus Nerve Stimulation(VNS) As Treatment For Fibromyalgia Patients
Recruiting
Ages 18 to 80 ยท All sexes ยท Updated Sep 14, 2026 ยท NCT06009159From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.