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Pain clinical trials in Chicago, IL

8 studies for Pain are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE)

RecruitingPhase 3
  • Ambros Clinical Trial Site, Chicago
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT07210515

VR and Cooled Genicular Nerve Radio Frequency Ablation for Chronic Knee Pain

Recruiting
  • Northwestern Medicine Pain Center, Chicago
Ages 18 and older · All sexes · Updated Oct 29, 2026 · NCT06336447

Anesthetics and Analgesics in Children

RecruitingObservational study
  • Ann and Robert H. Lurie Childrens Hospital of Chicago, Chicago
6 Months – 17 Years · All sexes · Updated Oct 16, 2026 · NCT03427736

Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain

Recruiting
  • Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago
Ages 16 to 39 · All sexes · Updated Oct 8, 2026 · NCT06374238

The Effect of Remotely Delivered Pilates on Physical , and Psychological Outcomes in Individuals With Multiple Sclerosis

Recruiting
  • University of Illinois Chicago, Chicago
Ages 18 and older · All sexes · Updated Oct 6, 2026 · NCT07504120

Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection

Recruiting
  • Hyde Park Clinic, Chicago
Ages 40 and older · All sexes · Updated Sep 4, 2026 · NCT07804446

Hip Arthroscopy Postoperative Opioid Demands

RecruitingHealthy volunteers welcome
  • Rush University Medical Center, Chicago
Ages 18 to 80 · All sexes · Updated Aug 13, 2026 · NCT04094701

(2R,6R)-Hydroxynorketamine for the Treatment of Neuropathic Pain

RecruitingPhase 1/2
  • Rush University Medical Center, Chicago
Ages 18 to 75 · All sexes · Updated Aug 3, 2026 · NCT05864053

About Pain

Pain is a feeling triggered in the nervous system. You may feel it as a prick, tingle, sting, burn, or ache. Read about the causes and what can help.

More about Pain on MedlinePlus

Pain trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.