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Non-Small Cell Lung Cancer clinical trials in Charlotte, NC

19 studies for Non-Small Cell Lung Cancer are looking for participants at sites in and around Charlotte (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

RecruitingPhase 3
  • Novant Health Weisiger Cancer Insititute ( Site 0266), Charlotte
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06623422

Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC

RecruitingPhase 3
  • Carolinas Medical Center, Charlotte
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT06765109

Pilot Study of Performance Status 2 vs. Performance Status 0-1 Non-small Cell Lung Cancer Patients Treated With Chemo/Immunotherapy

RecruitingPhase 2
  • Levine Cancer Institute, Charlotte
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT04253964

Pan-tumor MRD Study

RecruitingObservational study
  • Carolina Oncology Specialists, Charlotte
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06605404

Quick Start Durvalumab Following Chemoradiation for Stage III Nonsmall Cell Lung Cancer

RecruitingPhase 2
  • Atrium Health Levine Cancer, Charlotte
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT05696782

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

RecruitingPhase 1/2
  • Carolina Biooncology Institute, Huntersville · 13 mi away
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT05267626

Beamion LUNG-3: Adjuvant Zongertinib vs Standard Treatment in People With Completely Resected Stage II-IIIB NSCLC Harboring Activating HER2 TKD Mutations

RecruitingPhase 3
  • Levine Cancer Institute, Charlotte
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07195695

Safety and Preliminary Effectiveness of BNT317, an Investigational Therapy for Advanced Solid Tumors

RecruitingPhase 1/2
  • Carolina BioOncology Institute, LLC, Huntersville · 13 mi away
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06750185

First-In-Human Study of STX-721/PFL-721 in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR or HER2 Exon 20 Insertion Mutations

RecruitingPhase 1/2
  • Levine Cancer Institute - Charlotte, Charlotte
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT06043817

Cancer-related Fatigue During Maintenance Immunotherapy for Non-small Cell Lung Cancer (NSCLC): a Qualitative Study

RecruitingObservational study
  • Atrium Health Levine Cancer, Charlotte
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT06567704

A Study to Evaluate ARV-6723 Alone and With Pembrolizumab in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • Clinical Trial Site, Huntersville · 13 mi away
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT07749586

Study of XB010 in Subjects With Solid Tumors

RecruitingPhase 1
  • Carolina BioOncology Institute, Huntersville · 13 mi away
Ages 18 and older · All sexes · Updated Jun 22, 2026 · NCT06545331

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

RecruitingPhase 1
  • Carolina BioOncology Institute, Huntersville · 13 mi away
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT06040541

Dose Escalation/Expansion Study of Mavrostobart (PT199), an Anti-CD73 mAb, Administered Alone and in Combination With a PD-1 Inhibitor or Chemotherapy (the MORNINGSTAR Study)

RecruitingPhase 1/2
  • Carolina BioOncology Institute, Huntersville · 13 mi away
Ages 18 and older · All sexes · Updated May 19, 2026 · NCT05431270

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

RecruitingObservational study
  • Carolinas Medical Center/Levine Cancer Institute, Charlotte
  • Atrium Health Pineville/LCI-Pineville, Charlotte
  • Levine Cancer Institute-SouthPark, Charlotte
  • and 8 more
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT06418204

Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Carolina BioOncology Institute, Huntersville · 13 mi away
Ages 18 and older · All sexes · Updated Feb 18, 2026 · NCT07030257

A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas

RecruitingPhase 1
  • Dren Investigational Site, Huntersville · 13 mi away
Ages 18 and older · All sexes · Updated Jan 7, 2026 · NCT06999187

Non-Small Cell Lung Cancer trials in other cities

Other studies in Charlotte

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.