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Breast Cancer clinical trials in Oklahoma City, OK

17 studies for Breast Cancer are looking for participants at sites in and around Oklahoma City (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

The Vanguard Study: Testing a New Way to Screen for Cancer

RecruitingHealthy volunteers welcome
  • University of Oklahoma Health Sciences Center, Oklahoma City
Ages 45 to 75 · All sexes · Updated Oct 5, 2026 · NCT06995898

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • University of Oklahoma, Oklahoma City
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Mercy Hospital Oklahoma City, Oklahoma City
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

Phase II Protocol of Proton Therapy for Partial Breast Irradiation in Early Stage Breast Cancer

RecruitingPhase 2
  • Oklahoma Proton Center, Oklahoma City
Ages 50 and older · Women · Updated Sep 29, 2026 · NCT01766297

Study of AVZO-021 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • Avenzo Therapeutics Recruiting Site, Oklahoma City
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT05867251

Biopsy-site-marker in Breast Cancer

RecruitingObservational study
  • OU Health Stephenson Cancer Center, Oklahoma City
Ages 18 and older · Women · Updated Sep 22, 2026 · NCT07833566

A Phase 1/1b Study of IAM1363 in HER2 Cancers

RecruitingPhase 1
  • OU Health Stephenson Cancer Center, Oklahoma City
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06253871

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

RecruitingPhase 3
  • University of Oklahoma Health Sciences Center, Oklahoma City
  • Mercy Hospital Oklahoma City, Oklahoma City
Ages 18 to 60 · Women · Updated Sep 2, 2026 · NCT05879926

Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

RecruitingPhase 3
  • University of Oklahoma Health Sciences Center, Oklahoma City
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT06500481

E-Mindfulness Approaches for Living After Breast Cancer

RecruitingPhase 3
  • University of Oklahoma Health Sciences Center, Oklahoma City
Ages 18 to 50 · All sexes · Updated Aug 4, 2026 · NCT06748222

Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)

RecruitingPhase 1/2
  • University of Oklahoma - Health Sciences Center, Oklahoma City
Ages 18 and older · All sexes · Updated Aug 4, 2026 · NCT05579366

A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors

RecruitingPhase 1/2
  • Stephenson Cancer Center Oklahoma University Health, Oklahoma City
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05377996

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

RecruitingPhase 3
  • University of Oklahoma Health Sciences Center, Oklahoma City
  • Mercy Hospital Oklahoma City, Oklahoma City
Ages 50 to 70 · All sexes · Updated Apr 23, 2026 · NCT04852887

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

RecruitingObservational study
  • Mercy Hospital Oklahoma City, Oklahoma City
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT06418204

Neuromodulation of Cardiovascular Risks Associated With Cardiotoxic Chemotherapy

RecruitingEarly phase 1
  • Stephenson Cancer Center, Oklahoma City
Ages 18 to 99 · All sexes · Updated Jan 26, 2026 · NCT05921253

Navigator-Assisted Hypofractionation (NAVAH) on Radiation Therapy Completion in Breast Cancer and Prostate Cancer

RecruitingObservational study
  • OU Health Stephenson Cancer Center, Oklahoma City
Ages 18 and older · All sexes · Updated Dec 17, 2025 · NCT07014618

A Phase 1 Study of XL309 (ISM3091) Alone and in Combination in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • Exelixis Clinical Site #13, Oklahoma City
Ages 18 and older · All sexes · Updated Sep 5, 2025 · NCT05932862

About Breast Cancer

Breast cancer is a cancer that starts in the breast tissue, when cells change and grow out of control. These extra cells can form a mass called a tumor.

More about Breast Cancer on MedlinePlus

Breast Cancer trials in other cities

Other studies in Oklahoma City

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.