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Metastatic Cancer clinical trials in St. Louis, MO

54 studies for Metastatic Cancer are looking for participants at sites in and around St. Louis (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

RecruitingPhase 2

Washington University School of Medicine, St Louis
Mercy Hospital South, St Louis
Siteman Cancer Center-South County, St Louis
and 6 more

All ages · All sexes · Updated Oct 5, 2026 · NCT05564377

A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors

RecruitingPhase 1

Washington University Medicine, St Louis

Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06270706

Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene

RecruitingPhase 1

Washington University School of Medicine, St Louis

Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05372614

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1

Washington University School of Medicine in St. Louis, St Louis

Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06465069

A Study of HC-7366 in Combination With Belzutifan (WELIREG™) in Patients With Renal Cell Carcinoma

RecruitingPhase 1

Washington University School of Medicine, St Louis

Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06234605

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

RecruitingPhase 1

Washington University School of Medicine, St Louis

Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06625775

Study of Orellanine in Metastatic Clear-Cell or Papillary Renal Cell Carcinoma

RecruitingPhase 1/2

Washington University in St. Louis, St Louis

Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05287945

A Study of ASP3082 in Adults With Advanced Solid Tumors

RecruitingPhase 1

Washington University School of Medicine, St Louis

Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT05382559

Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

RecruitingPhase 2/3

Siteman Cancer Center, St Louis

Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT06943755

A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)

RecruitingPhase 3

Research Site, St Louis

Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06103864

ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer

RecruitingPhase 2

Washington University School of Medicine- Siteman Cancer Center, St Louis

Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07007559

A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations

RecruitingPhase 1/2

Washington University School of Medicine in St. Louis, St Louis

Up to age 25 · All sexes · Updated Sep 25, 2026 · NCT04094610

A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue

RecruitingPhase 2/3

Cancer Care Specialists of Illinois - Cancer Care Center of O'Fallon, O'Fallon · 16 mi away

Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06989437

A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)

RecruitingPhase 1/2

Washington University School of Medicine, St Louis

Ages 12 and older · All sexes · Updated Sep 24, 2026 · NCT05118789

A Study of LY4257496 in Participants With Cancer (OMNIRAY)

RecruitingPhase 1

Washington University, St Louis

Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07114601

SLV-154 Treatment of Advanced Cancers

RecruitingPhase 1

Washington University, St Louis

Ages 12 and older · All sexes · Updated Sep 22, 2026 · NCT06771219

A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

RecruitingPhase 3

Washington University School of Medicine, St Louis

Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07218380

A Study of Nuzefatide Pevedotin (BT5528) in Patients With Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)

RecruitingPhase 2

Siteman Cancer Center (Washington University School of Medicine), St Louis

Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07450859

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

RecruitingPhase 1/2

Washington University, St Louis

Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT05267626

Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer

RecruitingPhase 1/2

Siteman Cancer Center, St Louis
Barnes-Jewish Hospital, St Louis
Washington University School of Medicine - Siteman Cancer Center, St Louis
and 5 more

Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07227415

A Study of KK2269 in Adult Participants With Solid Tumors

RecruitingPhase 1

Washington University, St Louis

Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06266299

A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

RecruitingPhase 1

Washington University School of Medicine, St Louis

Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06440005

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

RecruitingPhase 1

Siteman Cancer Center at Washington University, St Louis

36 Months – 22 Years · All sexes · Updated Sep 4, 2026 · NCT03911388

Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

RecruitingPhase 2

Washington University School of Medicine, St Louis
Siteman Cancer Center-South County, St Louis
Siteman Cancer Center at Christian Hospital, St Louis
and 1 more

Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT06311214

A Study With NKT5097 for Adults With Advanced/Metastatic Solid Tumors

RecruitingPhase 1

Washington University, St Louis

Ages 18 and older · All sexes · Updated Aug 28, 2026 · NCT07029399

FORAGER-1: A Study of Vepugratinib (LY3866288; LOXO-435) in Participants With Cancer With a Change in a Gene Called FGFR3

RecruitingPhase 1

Washington University in St. Louis, St Louis

Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT05614739

FOG-001 in Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2

Washington University School of Medicine, St Louis

Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05919264

IDOV-Immune for Advanced Solid Tumors

RecruitingPhase 1

Washington University School of Medicine, St Louis

Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06910657

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2

Washington University, St Louis

Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT04657068

Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors

RecruitingPhase 1

Investigative Site #110, St Louis

Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT06545942

Study of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid Tumors

RecruitingPhase 1

Investigative Site #110, St Louis

Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT06974110

Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors

RecruitingPhase 1/2

Washington University, St Louis

Ages 12 and older · All sexes · Updated Jul 14, 2026 · NCT05533697

Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer

RecruitingPhase 1

Washington University School of Medicine, St Louis

Ages 18 and older · All sexes · Updated Jul 13, 2026 · NCT07137416

A Study of PYX-201 in Advanced Solid Tumors

RecruitingPhase 1

Washington University School of Medicine, St Louis

Ages 18 and older · All sexes · Updated Jun 30, 2026 · NCT05720117

LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC

RecruitingPhase 3

University of Kansas Cancer Center - Overland Park, Overland · 10 mi away

Ages 18 and older · All sexes · Updated Jun 25, 2026 · NCT06216301

A Study of XB628 Alone and in Combination With Zanzalintinib in Participants With Recurrent Advanced or Metastatic Solid Tumors

RecruitingPhase 1

Exelixis Clinical Site #6, St Louis

Ages 18 and older · All sexes · Updated Jun 24, 2026 · NCT06952010

A Study of LY4175408 in Participants With Advanced Cancer

RecruitingPhase 1

Washington University, St Louis

Ages 18 and older · All sexes · Updated Jun 23, 2026 · NCT07046923

REMASTer: REcurrent Brain Metastases After SRS Trial

Recruiting

WashU, St Louis

Ages 18 and older · All sexes · Updated Jun 18, 2026 · NCT05124912

(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors

RecruitingPhase 3

Washington University, St Louis

Ages 18 and older · All sexes · Updated Jun 16, 2026 · NCT05208047

Abiraterone, Enzalutamide, or Apalutamide in Castrate-sensitive Prostate Cancer.

RecruitingPhase 2

VA St. Louis Health Care System, St Louis

Ages 18 and older · Men · Updated Jun 15, 2026 · NCT05422911

First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1

Research Site, St Louis

Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT07284186

A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations

RecruitingPhase 1

Research Site, St Louis

Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06835569

A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)

RecruitingPhase 1/2

Washington University School of Medicine Siteman Cancer Center, St Louis

Ages 12 and older · All sexes · Updated May 27, 2026 · NCT05384626

Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)

RecruitingPhase 3

Washington University School of Medicine in Saint Louis, St Louis

Ages 18 and older · All sexes · Updated May 18, 2026 · NCT06757634

A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors

RecruitingPhase 1

Washington University School of Medicine, St Louis

Ages 18 and older · All sexes · Updated May 18, 2026 · NCT07094204

Safety and Efficacy of EIK1001 in Combo With Pembro Versus Placebo and Pembro as First-Line Therapy in Patients With Advanced Melanoma.

RecruitingPhase 2/3

Washington University School of Medicine in St. Louis, St Louis

Ages 18 and older · All sexes · Updated May 8, 2026 · NCT06697301

A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

RecruitingPhase 1/2

Washington University School of Medicine, St Louis

Ages 18 and older · All sexes · Updated Apr 22, 2026 · NCT07020221

A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma

RecruitingPhase 3

Siteman Cancer Center - Washington University, St Louis

Ages 18 and older · All sexes · Updated Apr 9, 2026 · NCT06064877

Collection and Storage of Tissue and Blood Samples From Patients With Cancer

RecruitingObservational study

Mercy Hospital South, St Louis
Missouri Baptist Medical Center, St Louis
Mercy Hospital Saint Louis, St Louis

2 Months · All sexes · Updated Mar 5, 2026 · NCT02474160

A Study of NVL-330 in Patients With Advanced or Metastatic HER2-altered NSCLC (HEROEX-1)

RecruitingPhase 1

Washington University, St Louis

Ages 18 and older · All sexes · Updated Feb 25, 2026 · NCT06521554

Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2

Washington University, St Louis

Ages 18 and older · All sexes · Updated Feb 18, 2026 · NCT07030257

Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen

RecruitingPhase 3

The Washington University, St Louis

Ages 18 and older · All sexes · Updated Feb 6, 2026 · NCT06127407

Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid Tumors

RecruitingPhase 1

Washington University Medical Campus, St Louis

Ages 18 and older · All sexes · Updated Dec 17, 2025 · NCT05856981

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study

Massive Bio SYNERGY-AI site, St Louis

All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Metastatic Cancer trials in other cities

Other studies in St. Louis

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.