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Head and Neck Squamous Cell Carcinoma clinical trials in Oklahoma City, OK

13 studies for Head and Neck Squamous Cell Carcinoma are looking for participants at sites in and around Oklahoma City (within about 30 miles). Open a study to see who can join and how to contact the study team.

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High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer

RecruitingPhase 3
  • University of Oklahoma Health Sciences Center, Oklahoma City
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06992427

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

RecruitingPhase 3
  • University of Oklahoma Health Sciences Center, Oklahoma City
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06589804

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

RecruitingPhase 2
  • University of Oklahoma Health Sciences Center, Oklahoma City
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT05136196

JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC

RecruitingPhase 3
  • Stephenson Cancer Center, Oklahoma City
Ages 60 and older · All sexes · Updated Sep 25, 2026 · NCT04892173

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

RecruitingPhase 2
  • University of Oklahoma Health Sciences Center, Oklahoma City
Ages 18 to 79 · All sexes · Updated Sep 22, 2026 · NCT04671667

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

RecruitingPhase 2
  • University of Oklahoma Health Sciences Center, Oklahoma City
  • Mercy Hospital Oklahoma City, Oklahoma City
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT02734537

A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors

RecruitingPhase 1
  • Normunity Investigational Site, Oklahoma City
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07182149

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

RecruitingPhase 2/3
  • University of Oklahoma Health Sciences Center, Oklahoma City
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT04333537

Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer

RecruitingPhase 2
  • University of Oklahoma Health Sciences Center, Oklahoma City
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT06532279

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • SSM OKC Hightower Clinical, Oklahoma City
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT03526835

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

RecruitingPhase 1
  • OU Health University of Oklahoma Medical Center, Oklahoma City
  • Stephenson Cancer Center (chemo location), Oklahoma City
  • University of Oklahoma Health Science Center, Oklahoma City
Ages 18 and older · All sexes · Updated Jul 6, 2026 · NCT04389632

A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas

RecruitingPhase 1
  • Dren Investigational Site, Oklahoma City
Ages 18 and older · All sexes · Updated Jan 7, 2026 · NCT06999187

A Study of NX-1607 in Adults With Advanced Malignancies

RecruitingPhase 1
  • University of Oklahoma, Oklahoma City
Ages 18 and older · All sexes · Updated Sep 9, 2025 · NCT05107674

Head and Neck Squamous Cell Carcinoma trials in other cities

Other studies in Oklahoma City

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.