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Metastatic Cancer clinical trials in Knoxville, TN

7 studies for Metastatic Cancer are looking for participants at sites in and around Knoxville (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

RecruitingPhase 2/3
  • University of Tennessee Medical Center, Knoxville
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT06943755

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

RecruitingPhase 3
  • Tennessee Cancer Specialists Dowell Springs location, Knoxville
  • University of Tennessee Medical Center, Knoxville
  • Tennessee Cancer Specialists - Parkwest Location, Knoxville
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07222566

CREO - Microwave Ablation Feasibility Study

Recruiting
  • University of Tennessee Medical, Knoxville
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT07817147

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

RecruitingPhase 3
  • University of Tennessee Medical Center, Knoxville
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06119581

A Study to See if Giving Fianlimab and Cemiplimab Together is Better Than Cemiplimab Alone at Treating Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

RecruitingPhase 2
  • University of Tennessee Medical Center, Knoxville
Ages 18 and older · All sexes · Updated Aug 21, 2026 · NCT06769698

Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)

RecruitingPhase 3
  • Research Site, Knoxville
Ages 18 and older · Women · Updated Jul 29, 2026 · NCT07044336

A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma

RecruitingPhase 2/3
  • University of Tennessee Medical Center, Knoxville
All ages · All sexes · Updated Apr 2, 2026 · NCT06581406

Metastatic Cancer trials in other cities

Other studies in Knoxville

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.