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Chronic Lymphocytic Leukemia clinical trials in Cleveland, OH

8 studies for Chronic Lymphocytic Leukemia are looking for participants at sites in and around Cleveland (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Testing the Addition of Anti-Cancer Drug Sonrotoclax, to the Standard Treatment Zanubrutinib, for Previously Untreated CLL/SLL

RecruitingPhase 3
  • Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland
  • Cleveland Clinic Foundation, Cleveland
  • Hillcrest Hospital Cancer Center, Mayfield Heights · 12 mi away
Ages 65 and older · All sexes · Updated Oct 2, 2026 · NCT07321652

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

RecruitingPhase 3
  • Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland
  • Cleveland Clinic Foundation, Cleveland
  • Hillcrest Hospital Cancer Center, Mayfield Heights · 12 mi away
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT04269902

A Study of NX-5948 in Adults With CLL/SLL Previously Treated With a Bruton's Tyrosine Kinase Inhibitor and a B-cell Lymphoma-2 Inhibitor (DAYBreak CLL-201)

RecruitingPhase 2
  • The Cleveland Clinic Foundation, Cleveland
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07221500

Rituximab (Rtx) + Tafasitamab in Combination With Allogeneic NK Cells for Treatment of Relapsed/Refractory (r/r) B-cell Non-Hodgkin Lymphoma (NHL)

RecruitingPhase 1
  • Case Comprehensive Cancer Center, University Hospitals Seidman Cancer Center, Cleveland
  • Case Comprehensive Cancer Center, Cleveland Clinic Foundation Taussig Cancer Institute, Cleveland
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07225439

A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies

RecruitingPhase 1
  • Cleveland Clinic, Cleveland
Ages 18 and older · All sexes · Updated Jul 2, 2026 · NCT05131022

A Study of AC676 for the Treatment of Relapsed/Refractory B-Cell Malignancies

RecruitingPhase 1
  • University Hospitals Cleveland Medical Center, Cleveland
Ages 18 and older · All sexes · Updated Oct 2, 2025 · NCT05780034

Chronic Lymphocytic Leukemia trials in other cities

Other studies in Cleveland

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.