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Breast Cancer clinical trials in Cleveland, OH
33 studies for Breast Cancer are looking for participants at sites in and around Cleveland (within about 30 miles). Open a study to see who can join and how to contact the study team.
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Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation
RecruitingPhase 3
- University Hospitals Seidman Cancer Center, Cleveland
A Trial to Evaluate Ovarian Suppression Following Subcutaneous ZOLADEX 10.8 mg in Premenopausal Women With Early-stage and Advanced HR+ Breast Cancer
RecruitingPhase 1
- Cleveland Clinic Foundation, Cleveland
S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity
RecruitingPhase 3
- Case Western Reserve University, Cleveland
- Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland
- Cleveland Clinic Foundation, Cleveland
- and 3 more
Trial of 225Ac-DOTATATE (RYZ101) in Subjects With ER+, HER2-negative Unresectable or Metastatic Breast Cancer Expressing SSTRs.
RecruitingPhase 1/2
- Research Facility, Cleveland
The Vanguard Study: Testing a New Way to Screen for Cancer
RecruitingHealthy volunteers welcome
- Louis Stokes Cleveland VA Medical Center, Cleveland
A Study With NKT5097 for Adults With Advanced/Metastatic Solid Tumors
RecruitingPhase 1
- Cleveland Clinic, Cleveland
Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer
Recruiting
- Cleveland Clinic, Cleveland
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
RecruitingPhase 3
- University Hospitals Cleveland Medical Center, Cleveland
- Fairview Hospital, Cleveland
- Cleveland Clinic - Hillcrest Hospital, Mayfield Heights · 12 mi away
A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer
RecruitingPhase 3
- Fairview Hospital, Cleveland
- Cleveland Clinic Foundation, Cleveland
- Hillcrest Hospital, Mayfield Heights · 12 mi away
A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
RecruitingPhase 2
- Cleveland Clinic - Oncology Department, Cleveland
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
RecruitingPhase 3
- Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland
- Cleveland Clinic Foundation, Cleveland
- South Pointe Hospital, Warrensville Heights · 9 mi away
- and 1 more
Real World Treatment Experience of Patients With Breast, Lung, Ovarian, Multiple Myeloma, or Acute Myelogenous Leukemia Using Remote Symptom Monitoring
RecruitingObservational study
- University Hospitals Seidman Cancer Center, Cleveland
A Phase 1 Study of LNCB74 in Advanced Solid Tumors
RecruitingPhase 1
- Cleveland Clinic Taussig Cancer Institute, Cleveland
A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations
RecruitingPhase 1/2
- UH Cleveland Medical Center, Cleveland
EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)
RecruitingObservational study
- Cleveland Clinic Main Campus, Cleveland
A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer
RecruitingPhase 1/2
- Cleveland Clinic Taussig Cancer Center, Cleveland
The Cancer of the Pancreas Screening-5 CAPS5)Study
RecruitingPhase 3
- Case Comprehensive Cancer Center, Case Western Medical Reserve, Cleveland
Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Breast Cancer w/Liver Dominant Disease
RecruitingPhase 2
- Cleveland Clinic, Cleveland
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
RecruitingPhase 1/2
- The Cleveland Clinic Taussig Cancer Center, Cleveland
Study of AVZO-021 in Patients With Advanced Solid Tumors
RecruitingPhase 1/2
- Avenzo Therapeutics Recruiting Site, Cleveland
A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)
RecruitingPhase 3
- Research Site, Cleveland
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors
RecruitingPhase 1/2
- Cleveland Clinic, Cleveland
Study to Investigate Efficacy of a Novel Probiotic on the Bacteriome and Mycobiome of Breast Cancer
Recruiting
- Cleveland Clinic Taussig Cancer institute, Case Comprehensive Cancer Center, Cleveland
A Phase 1/1b Study of IAM1363 in HER2 Cancers
RecruitingPhase 1
- University Hospital Cleveland Medical Center, Cleveland
- Cleveland Clinic, Cleveland
Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.
RecruitingPhase 3
- Cleveland Clinic, Cleveland
Repeat Breast Conserving Surgery Followed by Daily Partial Breast Irradiation in Ipsilateral Breast
RecruitingPhase 2
- University Hospitals Cleveland Medical Center, Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland
- Cleveland Clinic Taussig Cancer Center, Case Comprehensive Cancer Center, Cleveland
Finding the Best Tamoxifen Dose for Breast Cancer Risk Reduction in Premenopausal Women, RENAISSANCE Trial
RecruitingPhase 2
- Case Western Reserve University, Cleveland
TeleHealth Resistance Exercise Intervention to Preserve Dose Intensity and Vitality in Elder Breast Cancer Patients
Recruiting
- Case Western Reserve University/University Hospitals Cleveland, Cleveland
First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors
RecruitingPhase 1/2
- UH Cleveland Medical Center, Cleveland
I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer
RecruitingPhase 2
- Cleveland Clinic, Cleveland
De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)
RecruitingPhase 3
- Case Western Reserve University, Cleveland
- MetroHealth Medical Center, Cleveland
- Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland
- and 3 more
Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K Alteration and HR+/Her2- Breast Cancer
RecruitingPhase 1/2
- Cleveland Clinic, Cleveland
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
RecruitingObservational study
- Massive Bio SYNERGY-AI site, Mayfield Heights · 12 mi away
About Breast Cancer
Breast cancer is a cancer that starts in the breast tissue, when cells change and grow out of control. Learn about the types, diagnosis, and treatments.
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Breast Cancer trials in other cities
- New York City, NY144 studies
- Houston, TX126 studies
- Boston, MA110 studies
- Nashville, TN78 studies
- Los Angeles, CA73 studies
- Edison, NJ70 studies
- Queens, NY67 studies
- Durham, NC63 studies
- St. Louis, MO63 studies
- Chicago, IL59 studies
- Dallas, TX54 studies
- Philadelphia, PA51 studies
Other studies in Cleveland
- Non-Small Cell Lung Cancer48 studies
- Cancer (all types)36 studies
- Heart Failure31 studies
- Metastatic Cancer30 studies
- Prostate Cancer30 studies
- Ovarian Cancer29 studies
- Lung Cancer26 studies
- Colorectal Cancer25 studies
- Acute Myeloid Leukemia20 studies
- Head and Neck Squamous Cell Carcinoma20 studies
- Cardiovascular Disease20 studies
- Parkinson's Disease19 studies
From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.