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Endometrial Cancer clinical trials in Cleveland, OH

21 studies for Endometrial Cancer are looking for participants at sites in and around Cleveland (within about 30 miles). Open a study to see who can join and how to contact the study team.

Study of AVZO-021 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • Avenzo Therapeutics Recruiting Site, Cleveland
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT05867251

Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

RecruitingPhase 3
  • Case Western Reserve University, Cleveland
  • MetroHealth Medical Center, Cleveland
  • UHHS-Chagrin Highlands Medical Center, Beachwood · 10 mi away
  • and 1 more
Ages 18 and older · Women · Updated Sep 28, 2026 · NCT05256225

Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinoma

RecruitingPhase 2
  • Case Western Reserve University, Cleveland
  • Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland
  • Cleveland Clinic Foundation, Cleveland
  • and 3 more
Ages 18 and older · Women · Updated Sep 28, 2026 · NCT05112601

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

RecruitingPhase 2
  • Case Western Reserve University, Cleveland
  • UHHS-Chagrin Highlands Medical Center, Beachwood · 10 mi away
  • UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor · 22 mi away
All ages · All sexes · Updated Sep 28, 2026 · NCT05564377

Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

RecruitingPhase 3
  • Case Western Reserve University, Cleveland
  • UHHS-Chagrin Highlands Medical Center, Beachwood · 10 mi away
  • UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor · 22 mi away
Ages 18 and older · Women · Updated Sep 25, 2026 · NCT07198074

Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER

RecruitingPhase 2
  • Case Western Reserve University, Cleveland
  • UHHS-Chagrin Highlands Medical Center, Beachwood · 10 mi away
  • UH Seidman Cancer Center, Mentor · 22 mi away
Ages 18 and older · Women · Updated Sep 24, 2026 · NCT05640999

A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations

RecruitingPhase 1/2
  • UH Cleveland Medical Center, Cleveland
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07109726

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • The Cleveland Clinic Taussig Cancer Center, Cleveland
Ages 12 and older · All sexes · Updated Sep 15, 2026 · NCT04585750

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

RecruitingObservational study
  • Cleveland Clinic, Cleveland
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT05059444

Testing Different Amounts of the Combination of Drugs M1774 and ZEN-3694 for the Treatment of Recurrent Ovarian and Endometrial Cancer

RecruitingPhase 1
  • Cleveland Clinic Foundation, Cleveland
Ages 18 and older · Women · Updated Sep 3, 2026 · NCT05950464

A Phase 1 Study of LNCB74 in Advanced Solid Tumors

RecruitingPhase 1
  • Cleveland Clinic Taussig Cancer Institute, Cleveland
Ages 18 and older · All sexes · Updated Aug 21, 2026 · NCT06774963

FOG-001 in Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • University Hospitals Cleveland Medical Center, Seidman Cancer Center, Cleveland
  • Cleveland Clinic, Cleveland
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05919264

Study Evaluating the Safety and Efficacy of HWK-007, a PTK7-directed Antibody Drug Conjugate in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • University Hospital - Cleveland Medical Center, Cleveland
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT07444814

Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)

RecruitingPhase 3
  • Research Site, Cleveland
  • Research Site, Cleveland
Ages 18 and older · Women · Updated Jul 29, 2026 · NCT07044336

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

RecruitingPhase 1
  • University Hospitals Cleveland Medical Center, Cleveland
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT05208762

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • UH Cleveland Medical Center, Cleveland
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT05768139

Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer

RecruitingObservational study
  • Cleveland Clinic, Cleveland
Ages 18 and older · Women · Updated Apr 17, 2026 · NCT05051722

First in Human Study of TORL-1-23 in Participants With Advanced Cancer

RecruitingPhase 1
  • Cleveland Clinic, Cleveland
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT05103683

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

RecruitingObservational studyHealthy volunteers welcome
  • Cleveland Clinic, Cleveland
Ages 40 and older · All sexes · Updated Jan 20, 2026 · NCT05366881

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Mayfield Heights · 12 mi away
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Endometrial Cancer trials in other cities

Other studies in Cleveland

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.