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Lung Cancer clinical trials in Orange, CA

14 studies for Lung Cancer are looking for participants at sites in and around Orange (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC

RecruitingPhase 3
  • University of California, Irvine Health, Orange
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT06765109

A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)

RecruitingPhase 3
  • St. Joseph Hospital-The Center for Cancer Prevention and Treatment ( Site 4002), Orange
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06312137

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

RecruitingPhase 1/2
  • UC IRVINE Health, Orange
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06128551

Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

RecruitingPhase 2/3
  • University of California, Irvine (UCI) Health - UC Irvine Medical Center, Orange
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07100080

Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+)

Recruiting
  • Primary Care & Internal Medicine Services, Orange
  • UCI Chao Family Comprehensive Cancer Center, Orange
  • UCI Health SeniorHealth Center -Pavillion 4, Orange
  • and 1 more
Ages 50 to 80 · All sexes · Updated Sep 21, 2026 · NCT07711691

Patient-Derived Xenografts to Reduce Cancer Health Disparities

RecruitingObservational study
  • UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
Ages 21 to 100 · All sexes · Updated Aug 20, 2026 · NCT04410302

Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

RecruitingPhase 2
  • Chao Family Comprehensive Cancer Center, University of California Irvine, Orange
Ages 18 and older · All sexes · Updated Jul 14, 2026 · NCT06580002

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

RecruitingPhase 1/2
  • UC Irvine/Chao Family Comprehensive Cancer Center, Orange
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT05379985

TATE and Pembrolizumab (MK3475) in mCRC and NSCLC

RecruitingPhase 2
  • University of California, Irvine Medical Center, Orange
Ages 18 and older · All sexes · Updated Apr 16, 2026 · NCT04701476

Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial

RecruitingPhase 2
  • Chao Family Comprehensive Cancer Center, University of California Irvine, Orange
Ages 18 and older · All sexes · Updated Mar 3, 2026 · NCT07447050

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Orange
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Lung Cancer Screening of Family Members of Patients With Mutation-Driven Lung Cancer

Recruiting
  • Chao Family Comprehensive Cancer Center University of California, Irvine, Orange
Ages 18 to 80 · All sexes · Updated Jul 14, 2025 · NCT07062172

About Lung Cancer

Lung cancer forms in tissues of the lung, usually in the cells that line the air passages. It is the leading cause of cancer death in both men and women.

More about Lung Cancer on MedlinePlus

Lung Cancer trials in other cities

Other studies in Orange

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.