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Bladder Cancer clinical trials in St. Louis, MO

22 studies for Bladder Cancer are looking for participants at sites in and around St. Louis (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

RecruitingPhase 2
  • Washington University School of Medicine, St Louis
  • Mercy Hospital South, St Louis
  • Siteman Cancer Center-South County, St Louis
  • and 5 more
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT03866382

Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial

RecruitingPhase 2
  • Mercy Hospital South, St Louis
  • Missouri Baptist Medical Center, St Louis
  • Mercy Hospital Saint Louis, St Louis
  • and 1 more
Ages 18 and older · All sexes · Updated Nov 9, 2026 · NCT06770582

The Vanguard Study: Testing a New Way to Screen for Cancer

RecruitingHealthy volunteers welcome
  • Washington University School of Medicine, St Louis
Ages 45 to 75 · All sexes · Updated Nov 6, 2026 · NCT06995898

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1
  • Washington University School of Medicine in St. Louis, St Louis
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06465069

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Mercy Infusion Center - Chippewa, St Louis
  • Mercy Hospital South, St Louis
  • Missouri Baptist Medical Center, St Louis
  • and 4 more
Ages 40 to 75 · All sexes · Updated Nov 4, 2026 · NCT05334069

FORAGER-1: A Study of Vepugratinib (LY3866288; LOXO-435) in Participants With Cancer With a Change in a Gene Called FGFR3

RecruitingPhase 1
  • Washington University in St. Louis, St Louis
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT05614739

Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Invasive Bladder Cancer, BRIGHT Trial

RecruitingPhase 2
  • Cancer Care Center of O'Fallon, O'Fallon · 16 mi away
  • HSHS Saint Elizabeth's Hospital, O'Fallon · 16 mi away
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07061964

Enfortumab Vedotin in Combination With Pembrolizumab vs. Concurrent Chemoradiotherapy (cCRT) in People With Muscle Invasive Bladder Cancer (EV-309)

RecruitingPhase 3
  • Siteman Cancer Center, St Louis
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT07566156

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • Washington University, School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Oct 26, 2026 · NCT06172478

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study

RecruitingPhase 3
  • Mercy Hospital South, St Louis
  • Missouri Baptist Medical Center, St Louis
  • Mercy Hospital Saint Louis, St Louis
  • and 3 more
Ages 18 and older · All sexes · Updated Oct 23, 2026 · NCT07097142

Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer

RecruitingPhase 1/2
  • Siteman Cancer Center, St Louis
  • Barnes-Jewish Hospital, St Louis
  • Washington University School of Medicine - Siteman Cancer Center, St Louis
  • and 5 more
Ages 18 and older · All sexes · Updated Oct 8, 2026 · NCT07421700

A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

RecruitingPhase 3
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Oct 7, 2026 · NCT07218380

Efficacy and Safety of Intravesical TARA-002 Compared With Investigator's Choice of Intravesical Chemotherapy in Participants With BCG-naïve High-grade Non-muscle Invasive Bladder Cancer

RecruitingPhase 3
  • Renown Regional Medical Center, St Louis
Ages 18 and older · All sexes · Updated Oct 6, 2026 · NCT07480356

Personalized Cancer Vaccine (PCV) Strategy in Patients With Solid Tumors and Molecular Residual Disease

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT06529822

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

RecruitingPhase 1/2
  • Washington University, St Louis
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT05267626

Phase 2 Study to Evaluate Safety and Efficacy of Cretostimogene Grenadenorepvec in High-Risk NMIBC

RecruitingPhase 2
  • Specialty Clinical Research of St. Louis, St Louis
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06567743

Safety and Efficacy Study of Intravesical Instillation of TARA-002 in Adults With High-grade Non-muscle Invasive Bladder Cancer

RecruitingPhase 2
  • Renown Regional Medical Center, St Louis
  • Specialty Clinic Research of St. Louis, St Louis
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT05951179

IDOV-Immune for Advanced Solid Tumors

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06910657

Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies (ELEPHAS-05)

RecruitingObservational study
  • Mercy Hospital - South, St Louis
  • Mercy Hospital -STL, St Louis
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT07327489

Clinical Evaluation of BCDx for Monitoring of Recurrence in Non-Muscle Invasive Bladder Cancer

RecruitingObservational study
  • Washington University, St Louis
Ages 18 and older · All sexes · Updated Apr 23, 2026 · NCT05982561

Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Washington University, St Louis
Ages 18 and older · All sexes · Updated Feb 18, 2026 · NCT07030257

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, St Louis
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

About Bladder Cancer

Bladder cancer symptoms range from lower back pain to blood in your urine. Read about important risk factors and find a list of treatments available

More about Bladder Cancer on MedlinePlus

Bladder Cancer trials in other cities

Other studies in St. Louis

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.