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Bladder Cancer clinical trials in Philadelphia, PA

21 studies for Bladder Cancer are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Invasive Bladder Cancer, BRIGHT Trial

RecruitingPhase 2
  • University of Pennsylvania/Abramson Cancer Center, Philadelphia
  • Thomas Jefferson University Hospital, Philadelphia
  • Asplundh Cancer Pavilion, Willow Grove · 13 mi away
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07061964

Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial

RecruitingPhase 2
  • Christiana Care Health System-Concord Health Center, Chadds Ford · 23 mi away
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT06770582

A Clinical Study of Intismeran Autogene (V940) and BCG in People With Bladder Cancer (V940-011/INTerpath-011)

RecruitingPhase 2
  • MidLantic Urology ( Site 0102), Bala-Cynwyd · 5 mi away
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT06833073

A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors

RecruitingPhase 1
  • Sidney Kimmel Comprehensive Cancer Center Thomas Jefferson University, Philadelphia
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07277413

DESTINY-PANTUMOUR04

RecruitingObservational study
  • Research Site, Philadelphia
Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000

Prehabilitation in High-risk Oncologic Surgery

Recruiting
  • Fox Chase Cancer Center - Philadelphia, Philadelphia
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07638410

A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas

RecruitingPhase 1
  • Thomas Jefferson University, Sidney Kimmel Cancer Center, Philadelphia
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07217171

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

RecruitingObservational study
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT05059444

Phase 2 Study to Evaluate Safety and Efficacy of Cretostimogene Grenadenorepvec in High-Risk NMIBC

RecruitingPhase 2
  • University of Pennsylvania, Philadelphia
  • Midlantic Urology (Solaris), Bala-Cynwyd · 5 mi away
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06567743

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Reading Hospital McGlinn Cancer Institute at Phoenixville, Phoenixville · 22 mi away
Ages 40 to 75 · All sexes · Updated Sep 2, 2026 · NCT05334069

FORAGER-1: A Study of Vepugratinib (LY3866288; LOXO-435) in Participants With Cancer With a Change in a Gene Called FGFR3

RecruitingPhase 1
  • University of Pennsylvania, Philadelphia
  • Thomas Jefferson University, Philadelphia
Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT05614739

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study

RecruitingPhase 3
  • Christiana Care Health System-Concord Health Center, Chadds Ford · 23 mi away
  • Christiana Care Health System-Wilmington Hospital, Wilmington · 25 mi away
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07097142

LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve

RecruitingPhase 1/2
  • Thomas Jefferson University, Sidney Kimmel Cancer Center, Philadelphia
Ages 18 and older · All sexes · Updated Aug 7, 2026 · NCT04752722

Testing the Addition of an Anti-Cancer Drug, Gemcitabine, to Usual Treatment (BCG Alone) in People Whose Non-Muscle Invasive Bladder Cancer (NMIBC) Came Back After Prior BCG Therapy

RecruitingPhase 3
  • Fox Chase Cancer Center, Philadelphia
  • Fox Chase Cancer Center-Rockledge, Rockledge · 10 mi away
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT07000084

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

RecruitingPhase 2
  • Thomas Jefferson University, Philadelphia
Ages 8 and older · All sexes · Updated Jul 27, 2026 · NCT05503797

Adjuvant Concurrent Immunotherapy and Radiotherapy for the Treatment of Bladder Cancer

RecruitingPhase 1
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated May 14, 2026 · NCT06586255

Intravesical Treatment of Bladder Cancer at Home, Multi-modal Treatment Support

Recruiting
  • Abramson Cancer Center, Philadelphia
Ages 18 and older · All sexes · Updated May 13, 2026 · NCT07048496

Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Feb 18, 2026 · NCT07030257

Clinical Trial to Evaluate Post-Operative Outcomes of Ureteral Stent vs Ureteral Stent Free Radical Cystectomy

Recruiting
  • Thomas Jefferson University Hospital, Philadelphia
  • Jefferson Einstein Philadelphia Hospital, Philadelphia
Ages 18 to 85 · All sexes · Updated Feb 17, 2026 · NCT07234968

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

RecruitingPhase 1
  • Thomas Jefferson University, Sidney Kimmel Cancer Center, Philadelphia
  • Fox Chase Cancer Center, Philadelphia
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT06778863

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Philadelphia
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

About Bladder Cancer

Bladder cancer symptoms range from lower back pain to blood in your urine. Read about important risk factors and find a list of treatments available

More about Bladder Cancer on MedlinePlus

Bladder Cancer trials in other cities

Other studies in Philadelphia

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.