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Bladder Cancer clinical trials in Chicago, IL

21 studies for Bladder Cancer are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study to Learn About the Study Medicine PF-08052667 in People With Bladder Cancer

RecruitingPhase 1
  • Northwestern Memorial Hospital, Chicago
  • Northwestern University - Feinberg School of Medicine, Chicago
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07206225

Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial

RecruitingPhase 2
  • Rush MD Anderson Cancer Center, Chicago
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT06770582

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • University of Illinois Cancer Center, Chicago
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06172478

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

RecruitingPhase 2
  • Rush MD Anderson Cancer Center, Chicago
  • University of Chicago Comprehensive Cancer Center, Chicago
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT03866382

Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Invasive Bladder Cancer, BRIGHT Trial

RecruitingPhase 2
  • Northwestern University, Chicago
  • Northwestern Medicine Cancer Center Old Irving Park, Chicago
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT07061964

A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

RecruitingPhase 3
  • University of Illinois at Chicago, Chicago
  • University of Chicago Medical Center, Chicago
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07218380

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1
  • University of Chicago Hospital, Chicago
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT06465069

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Mount Sinai Hospital Medical Center, Chicago
  • John H Stroger Jr Hospital of Cook County, Chicago
  • University of Illinois, Chicago
  • and 1 more
Ages 40 to 75 · All sexes · Updated Sep 2, 2026 · NCT05334069

KEYMAKER-U04 Substudy 04D: A Clinical Study of New Treatments Given With Enfortumab Vedotin and Pembrolizumab in People With Urothelial Cancer (MK-3475-04D/KEYMAKER-U04)

RecruitingPhase 1/2
  • University of Chicago Medical Center ( Site 5037), Chicago
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT07232602

FORAGER-1: A Study of Vepugratinib (LY3866288; LOXO-435) in Participants With Cancer With a Change in a Gene Called FGFR3

RecruitingPhase 1
  • The University of Chicago Medical Center (UCMC), Chicago
Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT05614739

Measuring Surgical Recovery After Radical Cystectomy

RecruitingObservational study
  • University of Chicago, Chicago
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT03193970

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study

RecruitingPhase 3
  • Northwestern University, Chicago
  • Rush MD Anderson Cancer Center, Chicago
  • University of Illinois, Chicago
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07097142

Testing the Addition of an Anti-Cancer Drug, Gemcitabine, to Usual Treatment (BCG Alone) in People Whose Non-Muscle Invasive Bladder Cancer (NMIBC) Came Back After Prior BCG Therapy

RecruitingPhase 3
  • Northwestern University, Chicago
  • University of Illinois, Chicago
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT07000084

A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2

RecruitingPhase 2
  • UChicago Medicine - River East, Chicago
  • University of Chicago Medical Center, Chicago
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT04879329

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

RecruitingPhase 1
  • UChicago Medicine - River East, Chicago
  • The University Of Chicago, Chicago
  • University of Chicago Medical Center, Chicago
Ages 18 and older · All sexes · Updated Jul 6, 2026 · NCT04389632

Pemetrexed Response in Relation to Tumor Alterations of Gene Status for the Treatment of Patients With Metastatic Urothelial Bladder Cancer and Other Solid Tumors

RecruitingPhase 2
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT06630416

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

RecruitingPhase 1
  • The University of Chicago Comprehensive Cancer Center, Chicago
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT06778863

Blue Light Cystoscopy With Cysview® Registry

RecruitingObservational study
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Dec 18, 2025 · NCT02660645

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Chicago
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Prospective Validation Study of High Volume Urine DNA Testing in Individuals With Suspicion of Urothelial Cancer

RecruitingObservational study
  • Jesse Brown Department Of Veterans Affairs Medical Center, Chicago
Ages 18 to 100 · All sexes · Updated Oct 10, 2025 · NCT06310759

Comprehensive Geriatric Assessment (Tests) for Bladder Cancer Participants Undergoing Radical Cystectomy

Recruiting
  • University of Chicago Medicine Comprehensive Cancer Center, Chicago
Ages 65 and older · All sexes · Updated Oct 3, 2025 · NCT06427824

About Bladder Cancer

Bladder cancer symptoms range from lower back pain to blood in your urine. Read about important risk factors and find a list of treatments available

More about Bladder Cancer on MedlinePlus

Bladder Cancer trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.