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Cancer (all types) clinical trials in Durham, NC

59 studies for Cancer (all types) are looking for participants at sites in and around Durham (within about 30 miles). Open a study to see who can join and how to contact the study team.

Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

RecruitingPhase 3
  • Duke University Medical Center, Durham
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 and older · Women · Updated Sep 28, 2026 · NCT05256225

A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue

RecruitingPhase 2/3
  • UNC Hospitals, The University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
  • University of North Carolina Hospitals at Hillsborough, Hillsborough · 13 mi away
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06989437

A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer

RecruitingPhase 3
  • Duke University Medical Center - Duke Cancer Centre, Durham
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06901531

Pivotal Open-label Phase 3 Clinical Study of QTX-2101 in Adult Patients With Acute Promyelocytic Leukemia

RecruitingPhase 3
  • Quetzal Site 27, Chapel Hill · 10 mi away
Ages 18 to 71 · All sexes · Updated Sep 23, 2026 · NCT07504458

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

RecruitingPhase 2
  • Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 12 and older · All sexes · Updated Sep 22, 2026 · NCT02693535

Study of the Effect of Innate on the Inflammatory Response to Endotoxin

RecruitingObservational studyHealthy volunteers welcome
  • NIEHS Clinical Research Unit (CRU), Research Triangle Park · 7 mi away
Ages 18 to 100 · All sexes · Updated Sep 22, 2026 · NCT01143480

Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells

RecruitingPhase 2/3
  • Duke University Medical Center, Durham
  • The University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
All ages · All sexes · Updated Sep 18, 2026 · NCT03435796

Digital Art Therapy for Young Cancer Survivors

Recruiting
  • Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 to 25 · All sexes · Updated Sep 17, 2026 · NCT06789666

Autologous CAR-T Cells Targeting CSPG4 in Relapsed/Refractory HNSCC

RecruitingPhase 1
  • Lineberger Comprehensive Cancer Center at University of North Carolina Chapel Hill, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT06096038

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

RecruitingPhase 2
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 18 to 80 · All sexes · Updated Sep 15, 2026 · NCT07002034

A Study to Assess Adverse Events and Change in Disease Activity of Oral Surzetoclax Alone or in Combination With Subcutaneous and/or Oral Antimyeloma Agents in Adult Participants With Multiple Myeloma (MM)

RecruitingPhase 1/2
  • University of North Carolina at Chapel Hill /ID# 272454, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT06953960

A Phase 1/1b Study of IAM1363 in HER2 Cancers

RecruitingPhase 1
  • Duke Cancer Institute, Durham
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06253871

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

RecruitingPhase 3
  • Duke Cancer Institute, Durham
  • University of North Carolina Medical Center, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06119581

Project: Every Child for Younger Patients With Cancer

RecruitingObservational study
  • Duke University Medical Center, Durham
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Up to age 25 · All sexes · Updated Aug 25, 2026 · NCT02402244

Using Tailored mHealth Strategies to Promote Weight Management Among Adolescent and Young Adult Cancer Survivors

Recruiting
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 18 to 39 · All sexes · Updated Aug 24, 2026 · NCT06848491

Abatacept in Immune Checkpoint Inhibitor Myocarditis

RecruitingPhase 3
  • University of North Carolina Chapel Hill, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT05335928

Ulixertinib/Palbociclib in Patients With Advanced Pancreatic and Other Solid Tumors

RecruitingPhase 1
  • Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 to 99 · All sexes · Updated Aug 19, 2026 · NCT03454035

FOG-001 in Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Duke University, Durham
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05919264

Behavioral Pain Intervention for Older Cancer Patients

Recruiting
  • Duke Cancer Network, Durham
Ages 55 and older · Women · Updated Aug 12, 2026 · NCT07300995

A Study to Assess BMS-986460 in Participants With Metastatic Castration-resistant Prostate Cancer

RecruitingPhase 1
  • Duke Cancer Institute, Durham
Ages 18 and older · Men · Updated Aug 10, 2026 · NCT06067841

Expanding the Support of Family Caregivers of Diverse Patients With Cancer and Diabetes

RecruitingHealthy volunteers welcome
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 to 99 · All sexes · Updated Aug 10, 2026 · NCT07061652

Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer

RecruitingPhase 3
  • Duke University Medical Center, Durham
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Aug 7, 2026 · NCT06580314

A Study of PHN-012 in Patients With Advanced Solid Tumors

RecruitingPhase 1
  • PHN-012-001 Site, Durham
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT07127874

A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Multiple Myeloma Receiving T Cell Engaging Bi/Tri-specific Antibodies Intravenously (IV)/Subcutaneously (SC) Alone or in Combinations

RecruitingPhase 1/2
  • University of North Carolina at Chapel Hill /ID# 274667, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Jul 21, 2026 · NCT06892522

A Study to Assess Adverse Events of Intravenously (IV) Infused Etentamig (ABBV-383) in Adult Participants With Relapsed or Refractory Multiple Myeloma

RecruitingPhase 1
  • University of North Carolina /ID# 251203, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Jul 13, 2026 · NCT05650632

A Clinical Study of KTX-2001 in Subjects With Metastatic Castration-Resistant Prostate Cancer (STRIKE-001)

RecruitingPhase 1
  • Duke Cancer Center, Durham
Ages 18 and older · Men · Updated Jul 9, 2026 · NCT07103018

A Study of Mocertatug Rezetecan in Combination With Anti-cancer Therapies for Advanced Solid Tumors (BEHOLD-2)

RecruitingPhase 1/2
  • GSK Investigational Site, Durham
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT06796907

A Decisional Intervention for Older Adults With Acute Myeloid Leukemia and Their Caregivers

Recruiting
  • University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 60 and older · All sexes · Updated Jul 6, 2026 · NCT06697600

Artificial Intelligence (AI)-Enhanced Pretreatment Peer-review Process to Improve Patient Safety in Radiation Oncology

RecruitingHealthy volunteers welcome
  • University of North Carolina at Chapel Hill, Department of Radiation Oncology, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Jun 23, 2026 · NCT07463833

Preventing Liver Cancer Mortality Through Imaging With Ultrasound vs. MRI

Recruiting
  • Durham VA Medical Center, Durham, NC, Durham
Ages 18 to 75 · All sexes · Updated Jun 17, 2026 · NCT05486572

Tempus Small Cell Lung Cancer Observational Study (Sculptor)

RecruitingObservational study
  • University of North Carolina, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Jun 15, 2026 · NCT05257551

A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations

RecruitingPhase 1
  • Research Site, Durham
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06835569

Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors

RecruitingPhase 1
  • Duke Cancer Center /ID# 251975, Durham
Ages 18 and older · All sexes · Updated Jun 4, 2026 · NCT04777994

Isa-Rd for Frail and/or Much Older Patients With Newly Diagnosed Multiple Myeloma

RecruitingPhase 2
  • Duke Comprehensive Cancer Center, Durham
  • University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Jun 2, 2026 · NCT05145400

Preserving Physical Function in Older Adults With Cancer: Impact of an Optimizing Nutrition Intervention Applied Before and After Surgery

Recruiting
  • Durham VA Medical Center, Durham, NC, Durham
Ages 55 and older · All sexes · Updated May 20, 2026 · NCT05912257

Improving Outcomes in Early Menopause After Cancer

Recruiting
  • Duke Cancer Institute, Durham
Ages 18 to 44 · Women · Updated May 14, 2026 · NCT06982677

UNC Childhood, Adolescent, and Young Adult Cancer Cohort

RecruitingObservational study
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 1 to 39 · All sexes · Updated May 12, 2026 · NCT05096923

UNC Metastatic Cancer Radiation Therapy Registry

RecruitingObservational study
  • Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT06306924

Pilot Study of Mindset Moments Among Adolescent and Young Adult Cancer Survivors

RecruitingHealthy volunteers welcome
  • Duke Cancer Institute, Durham
Ages 19 to 25 · All sexes · Updated May 6, 2026 · NCT06732375

Local Radiofrequency Ablation Plus External Beam Radiation for the Treatment of Painful Thoracic and Lumbar Spine Tumors

RecruitingObservational study
  • UNC Hospitals, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Apr 23, 2026 · NCT07479199

CA-4948-101: Open-Label, Dose Escalation and Expansion Trial of Emavusertib (CA-4948) in Relapsed or Refractory Primary Central Nervous System Lymphoma (R/R PCNSL)

RecruitingPhase 1/2
  • Duke University Medical Center, Duke Cancer Center, Durham
Ages 18 and older · All sexes · Updated Apr 16, 2026 · NCT03328078

Veterans Affairs Lung Cancer Surgery Or Stereotactic Radiotherapy

Recruiting
  • Durham VA Medical Center, Durham, NC, Durham
Ages 18 and older · All sexes · Updated Feb 19, 2026 · NCT02984761

Rehabilitation Outcomes Study

Recruiting
  • The N.C. Cancer Hospital, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Feb 17, 2026 · NCT06674889

Cancer and Mild Cognitive Impairment Dyadic Intervention

Recruiting
  • Duke University, Durham
Ages 18 to 100 · All sexes · Updated Feb 10, 2026 · NCT05144516

Study to Assess Change in Disease Activity and Adverse Events of Oral Venetoclax With Intravenous (IV) Obinutuzumab in Adult Participants With Recurring Chronic Lymphocytic Leukemia (CLL)

RecruitingPhase 2
  • University of North Carolina /ID# 233313, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Feb 9, 2026 · NCT04895436

GEMINI-NSCLC: NSCLC Biomarker Study

RecruitingObservational study
  • Duke University, Durham
  • UNC, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Feb 5, 2026 · NCT05236114

Symptom Management and Transitioning to Engagement With Post-treatment Care for Adolescent and Young Adult Cancer Survivors

Recruiting
  • Duke Cancer Institute, Durham
Ages 18 to 39 · All sexes · Updated Jan 28, 2026 · NCT06371768

Effectiveness of Central Oncology Navigation and the Use of an ORN

Recruiting
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Jan 28, 2026 · NCT06618274

Cognitive Behavioral Theory-assisted Virtual Reality for Chronic CANcer Pain (VR-CAN)

Recruiting
  • Duke University School of Medicine, Durham
Ages 18 and older · All sexes · Updated Jan 6, 2026 · NCT07318519

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Chapel Hill · 10 mi away
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer

RecruitingObservational study
  • Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill · 10 mi away
Ages 18 to 120 · All sexes · Updated Oct 27, 2025 · NCT01137643

Young Adult Infusion Space Experience Satisfaction Survey

RecruitingObservational study
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 to 39 · All sexes · Updated Oct 24, 2025 · NCT05720546

UNC Pleural Fluid Registry

RecruitingObservational study
  • UNC Lingeberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Oct 16, 2025 · NCT05620329

A Study of NX-1607 in Adults With Advanced Malignancies

RecruitingPhase 1
  • University of North Carolina, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 9, 2025 · NCT05107674

uTRACT Jelmyto Registry: A Registry of Patients With Upper Tract Urothelial Cancer (UTUC) Treated With Jelmyto

RecruitingObservational study
  • The University of North Carolina Chapel Hill, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Feb 28, 2025 · NCT05874921

Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

Recruiting
  • Duke University Medical Center, Durham
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
  • University of North Carolina Hospitals - Hillsborough Campus, Hillsborough · 13 mi away
Ages 18 and older · All sexes · Updated Nov 27, 2024 · NCT03860883

About Cancer (all types)

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Other studies in Durham

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.