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Colon Cancer clinical trials in California

40 studies for Colon Cancer are looking for participants at sites in California.

Cities in California

A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)

  • Orange Coast Memorial Medical Center ( Site 2007), Fountain Valley
  • Los Angeles Hematology Oncology Medical Group ( Site 0084), Los Angeles
  • UCLA Hematology/Oncology - Santa Monica ( Site 0088), Santa Monica
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT06997497

Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

  • UCSF at Berkeley Outpatient Center, Berkeley
  • Alta Bates Summit Medical Center-Herrick Campus Comprehensive Cancer Center, Berkeley
  • UCSD Medical Center - Encinitas, Encinitas
  • and 21 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07222800

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

  • UC IRVINE Health, Orange
  • UC Davis Comprehensive Cancer Center, Sacramento
  • Stanford Cancer Institute, Stanford
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06128551

A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer

  • Memorial Care Orange Coast Medical Center, Fountain Valley
  • Providence Medical Foundation, Fullerton
  • Cancer & Blood Research Center, Los Alamitos
  • and 1 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07284849

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

  • University of California, San Diego, La Jolla
  • Hoag Memorial Hospital Presbyterian, Newport Beach
  • Redwood City, Redwood City
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT05059444

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

  • Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande
  • Mercy Cancer Center - Carmichael, Carmichael
  • Mercy San Juan Medical Center, Carmichael
  • and 8 more
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT07283939

Family Communications After Genetic Testing

  • Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande
  • Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank
  • Marshall Cancer Center, Cameron Park
  • and 17 more
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT07143487

Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease

  • Kaiser Permanente-Anaheim, Anaheim
  • Kaiser Permanente-Deer Valley Medical Center, Antioch
  • Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande
  • and 100 more
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT05174169

Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps

  • Kaiser Permanente-Anaheim, Anaheim
  • Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande
  • PCR Oncology, Arroyo Grande
  • and 28 more
Recruiting
Ages 45 to 70 · All sexes · Updated Sep 2, 2026 · NCT05080673

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of CBI-1214 T Cell Engager in Participants With Advanced or Metastatic MSS/MSI-L Colorectal Cancer

  • City of Hope Duarte, Duarte
  • UCLA, Los Angeles
  • Valkyrie Clinical Trials, Los Angeles
  • and 1 more
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 26, 2026 · NCT07321106

Shield Post-Approval Study Protocol

  • Elite Primary Physicians, Inc., Anaheim
  • Alliance Research Institute, LLC, Canoga Park
  • Amicis Research Center, Granada Hills
  • and 4 more
RecruitingObservational studyHealthy volunteers welcome
Ages 45 to 81 · All sexes · Updated Aug 7, 2026 · NCT06880055

A Study of PHN-012 in Patients With Advanced Solid Tumors

  • PHN-012-001 Site, Los Angeles
  • PHN-012-001 Site, San Diego
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT07127874

Distance-Based Exercise to Preserve Function and Prevent Disability

  • Kaiser Permanente Dublin, Dublin
  • Kaiser Permanente-Fremont, Fremont
  • Kaiser Permanente Fresno Orchard Plaza, Fresno
  • and 6 more
Recruiting
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT07059884

Study of XmAb®819 in Subjects With Advanced Clear Cell Renal Cell Carcinoma

  • Xencor Investigative Site, Duarte
  • Xencor Investigative Site, Sacramento
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 3, 2026 · NCT05433142

A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid Tumors

  • City of Hope (City of Hope National Medical Center, City of Hope Medical Center), Duarte
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT07318805

Early Onset Colorectal Cancer Detection

  • City of Hope Medical Center, Duarte
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 50 · All sexes · Updated Jul 7, 2026 · NCT06342401

An Exosomal microRNA Signature for Preoperative Staging in Colon Cancer

  • City of Hope Medical Center, Duarte
RecruitingObservational study
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT07255729

Early Detection of Advanced Adenomas and Colorectal Cancer

  • City of Hope Medical Center, Monrovia
  • University of California San Diego, San Diego
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT06342440

Navigation Intervention for Adolescent and Young Adult Cancer Survivors

  • KP Southern California - Department of Research & Evaluation, Pasadena
Recruiting
Ages 21 to 45 · All sexes · Updated Jul 6, 2026 · NCT07406087

EXoPERT EMERALD Clinical Study

  • Tibor Rubin VA Medical Center, Long Beach
  • City of Hope Duarte Cancer Center, Los Angeles
RecruitingObservational studyHealthy volunteers welcome
Ages 45 and older · All sexes · Updated Jul 1, 2026 · NCT07186296

Neoadjuvant Botensilimab and Balstilimab for the Treatment of Advanced Resectable Colorectal Cancer NEST3

  • City of Hope Corona, Corona
  • City of Hope Medical Center, Duarte
  • City of Hope Seacliff, Huntington Beach
  • and 4 more
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 1, 2026 · NCT07595874

A Phase 1 Dose-escalation Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation

  • Cedars-Sinai Medical Center, Los Angeles
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT07458347

A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies

  • University of California, Los Angeles (UCLA) Department of Medicine - Hematology/Oncology, Los Angeles
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jun 23, 2026 · NCT04678648

A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

  • UCSD Moores Cancer Center, La Jolla
  • UCLA Medical Center, Los Angeles
  • Stanford University, Stanford
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT06051695

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

  • University of California, Davis Comprehensive Cancer Center, Sacramento
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT06040541

Evaluation of SINGLE PORT (SP) Robotic Technology in Colorectal Surgery

  • UC Davis Medical Center, Sacramento
Recruiting
Ages 18 and older · All sexes · Updated May 29, 2026 · NCT05321134

A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

  • St Joseph Heritage Healthcare, Santa Rosa
RecruitingPhase 1/2
Ages 12 and older · All sexes · Updated May 27, 2026 · NCT03093116

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

  • UC Irvine/Chao Family Comprehensive Cancer Center, Orange
  • UCLA, Santa Monica
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT05379985

Study of ctDNA Guided Change in Tx for Refractory Minimal Residual Disease in Colon Adenocarcinomas

  • Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange
RecruitingPhase 1
Ages 18 and older · All sexes · Updated May 11, 2026 · NCT04920032

Evaluation of Stool Based Markers for the Early Detection of Colorectal Cancers and Adenomas

  • Cedars-Sinai Medical Center, Los Angeles
RecruitingObservational study
Ages 18 and older · All sexes · Updated May 11, 2026 · NCT00843375

Comparative Effectiveness Trial of Two Supportive Cancer Care Delivery Models for Adults With Cancer

  • Beckman Research Institute of City of Hope, Duarte
  • VA Medical Center, Fresno, Fresno
  • Santa Clara Valley Medical Center, Fruitdale
  • and 5 more
Recruiting
Ages 18 and older · All sexes · Updated Apr 30, 2026 · NCT05297734

Phase II Trial of Lung Chemoemobolization

  • City of Hope Medical Center, Duarte
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Mar 5, 2026 · NCT05672108

Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes

  • Cedars-Sinai Medical Center, Los Angeles
Recruiting
Ages 18 to 99 · All sexes · Updated Feb 20, 2026 · NCT04907643

Phase 1/2 Dose Finding, Safety and PK Study in Advanced Refractory Solid Tumors

  • UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Feb 17, 2026 · NCT07145255

Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer

  • GSK Investigational Site, Los Angeles
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Jan 23, 2026 · NCT05855200

Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon Cancer

  • Kaiser Permanente Northern California, Oakland
Recruiting
Ages 18 and older · All sexes · Updated Jan 7, 2026 · NCT05773144

Phytocannabinoids for Reducing Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors

  • City of Hope Medical Center, Duarte
  • City of Hope at Irvine Lennar, Irvine
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Dec 5, 2025 · NCT06731894

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

  • Massive Bio SYNERGY-AI site, Duarte
  • Massive Bio SYNERGY-AI site, Irvine
  • Massive Bio SYNERGY-AI site, La Jolla
  • and 3 more
RecruitingObservational study
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression

  • UCSD Moores Cancer Center, La Jolla
  • UCLA Medical Center, Los Angeles
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 9, 2025 · NCT06682793

APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

  • Cedars-Sinai Medical Center - Samuel Oschin Comprehensive Cancer Institute, Los Angeles
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jun 27, 2025 · NCT03175224

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.