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Degenerative Nerve Diseases clinical trials recruiting in the U.S.

32 studies for Degenerative Nerve Diseases are recruiting participants at sites across the United States.

Neurodegenerative (degenerative nerve) diseases are disorders that destroy motor neurons. Parkinson's is an examples. See a list of all the diseases.

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Recently updated studies

An Open-Label Exploratory Study of Fosigotifator in Participants With Vanishing White Matter Disease

RecruitingPhase 1/2
6 Months · All sexes · Updated Sep 24, 2026 · NCT05757141

A Study of LY3439539 in Participants With Alzheimer's Disease

RecruitingPhase 1
Ages 50 to 85 · All sexes · Updated Sep 24, 2026 · NCT07598370

A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)

RecruitingPhase 2
Ages 55 to 85 · All sexes · Updated Sep 22, 2026 · NCT07589595

Home Exercise for Individuals With Neurodegenerative Disease

RecruitingHealthy volunteers welcome
Ages 5 to 75 · All sexes · Updated Sep 16, 2026 · NCT05443906

Prenatal Education on Environmental Exposures During Pregnancy Study (PEEPS)

RecruitingHealthy volunteers welcome
Ages 18 and older · Women · Updated Sep 14, 2026 · NCT07758114

Observational Pharmaco-Epidemiology Research & Analysis

RecruitingObservational studyHealthy volunteers welcome
Ages 0 and older · All sexes · Updated Sep 11, 2026 · NCT03813862

Parkinson Progression Marker Initiative Online (PPMI Online)

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT05065060

Human Observatory Study

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT07646782

Friedreich Ataxia Global Clinical Consortium UNIFIED Natural History Study

RecruitingObservational studyHealthy volunteers welcome
All ages · All sexes · Updated Sep 1, 2026 · NCT06016946

Biofluid Research on Age-Related or Inherited Neurodegeneration

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT07798700

A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease Psychosis

RecruitingPhase 2
Ages 55 to 90 · All sexes · Updated Aug 27, 2026 · NCT06887192

Slow-SPEED: Slowing Parkinson's Early Through Exercise Dosage

Recruiting
Ages 50 and older · All sexes · Updated Aug 27, 2026 · NCT06993142

The Neurodevelopmental and Behavioral Phenotyping Screening Protocol

RecruitingObservational studyHealthy volunteers welcome
6 Weeks · All sexes · Updated Aug 24, 2026 · NCT00271622

A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease

RecruitingPhase 1
Ages 50 to 85 · All sexes · Updated Aug 24, 2026 · NCT06297590

Transplantation of Human iPS Cell-derived Dopaminergic Progenitors (CT1-DAP001) for Parkinson's Disease (Phase I/II)

RecruitingPhase 1
Ages 40 to 75 · All sexes · Updated Aug 17, 2026 · NCT06482268

Characterization of the Serotonin 2A Receptor Selective PET Tracer [18F]MH.MZ in Patients With Neurodegenerative Diseases

RecruitingPhase 4Healthy volunteers welcome
Ages 50 to 85 · All sexes · Updated Aug 7, 2026 · NCT05357612

PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

RecruitingObservational studyHealthy volunteers welcome
Ages 30 and older · All sexes · Updated Jul 27, 2026 · NCT04477785

Imaging Studies in Corticobasal Syndrome

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jul 14, 2026 · NCT07000851

Analysis of Human ALS Tissues and Registry of ALS Patients

RecruitingObservational study
Ages 18 to 90 · All sexes · Updated Jul 8, 2026 · NCT05067179

Neurologic Stem Cell Treatment Study

Recruiting
Ages 18 and older · All sexes · Updated Jun 26, 2026 · NCT02795052

Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia

RecruitingHealthy volunteers welcome
Ages 40 and older · All sexes · Updated Jun 10, 2026 · NCT05741853

F 18 T807 Tau PET Imaging of Alzheimer's Disease

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT02414347

Intraneural Administration of scAAV9/JeT-GAN Into the Vagus Nerve for Patients With Giant Axonal Neuropathy (GAN)

RecruitingPhase 1
Ages 10 to 25 · All sexes · Updated Apr 22, 2026 · NCT07543991

Intervention for Communication Quality of Life in Primary Progressive Aphasia

Recruiting
Ages 40 and older · All sexes · Updated Apr 21, 2026 · NCT07219680

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.