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Depression clinical trials in Massachusetts
63 studies for Depression are looking for participants at sites in Massachusetts.
Cities in Massachusetts
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
- Adams Clinical Boston, Boston
- Adams Clinical Watertown, Watertown
RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Nov 13, 2026 · NCT06793397Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression
- Massachusetts General Hospital, Boston
RecruitingPhase 4
Ages 18 to 70 · All sexes · Updated Nov 10, 2026 · NCT05450432RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
- Dana Farber Cancer Institute, Boston
- University of Massachusetts Chan Medical Center, Worcester
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Nov 10, 2026 · NCT07002034A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
- Seaport Investigator Site, Boston
- Seaport Investigator Site, Russells Mills
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Nov 10, 2026 · NCT07065240A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
- Massachusetts General Hospital, Boston
Recruiting
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT03887715E-Mindfulness Approaches for Living After Breast Cancer
- Beverly Hospital, Beverly
- Tufts Medical Center, Boston
- Dana-Farber Cancer Institute, Boston
- and 6 more
RecruitingPhase 3
Ages 18 to 50 · All sexes · Updated Nov 4, 2026 · NCT06748222A Study of Brenipatide in Adult Participants With Major Depressive Disorder
- Adams Clinical Boston, Boston
- K2 Medical Research - Foxborough, Foxborough
- Adams Clinical Watertown, Watertown
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Nov 4, 2026 · NCT07412756A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
- Adams Clinical Boston, Boston
- Adams Clinical Watertown, Watertown
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Nov 3, 2026 · NCT07775300TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age
- Massachusetts General Hospital, Boston
RecruitingObservational study
18 Months – 11 Years · All sexes · Updated Nov 3, 2026 · NCT07048574Early Life Stress and Depression: Molecular and Functional Imaging
- McLean Hospital, Belmont
RecruitingObservational studyHealthy volunteers welcome
Ages 20 to 32 · Women · Updated Nov 2, 2026 · NCT04713722Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Boston
- Neurocrine Clinical Site, Watertown
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT06966401Single Day of Ultra-accelerated TMS With a Single Dose of NRX-101
- McLean Hospital, Belmont
RecruitingEarly phase 1
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT07785102Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder
- McLean Hospital, Belmont
RecruitingPhase 1/2Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT07593222A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
- Clinical Research Site, Methuen
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT07621237Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab
- Massachusetts General Hospital, Boston
RecruitingPhase 2
Ages 25 to 50 · All sexes · Updated Oct 27, 2026 · NCT06136546Teenthrive 2: Treatments for Improving Mood in Teens
- Beth Israel Deaconess Medical Center, Boston
Recruiting
Ages 12 to 18 · All sexes · Updated Oct 26, 2026 · NCT07475845Effects of Intranasal Oxytocin in Patients With Arginine-vasopressin Deficiency
- Massachusetts General Hospital, Neuroendocrine Unit, Boston
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 26, 2026 · NCT04789148A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS Trial
- Harvard Mclean Hospital, Belmont
RecruitingPhase 2/3
Ages 18 to 80 · All sexes · Updated Oct 21, 2026 · NCT07227103Pilot Study of a Behavioral Program for Resident Depression in Skilled Nursing Facilities
- Massachusetts General Hospital, Boston
Recruiting
Ages 18 and older · All sexes · Updated Oct 20, 2026 · NCT07655232A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
- Draig Clinical Site, Boston
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Oct 14, 2026 · NCT07610473A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
- Draig Clinical Site, Watertown
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Oct 8, 2026 · NCT07300969Adapting and Pilot Testing a Skills-based Smoking Cessation Intervention to Address Developmental and Health-related Stress Among Adults Who Smoke
- Fenway Health, Boston
Recruiting
Ages 18 and older · All sexes · Updated Oct 8, 2026 · NCT06654414Stress Management and Meditative Movements for Asian Americans With Depression and Physical Symptoms
- Depression Clinical and Research Program, Boston
Recruiting
Ages 18 and older · All sexes · Updated Oct 7, 2026 · NCT07610928RISE Versus Advocacy-based Enhanced Care as Usual for Patients Experiencing IPV
- VA Boston Healthcare System, Boston
Recruiting
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT06906302The Medically Tailored Groceries and Mental Health Study
- UMass Chan Medical School, Worcester
- Community Care Cooperative (C3), Worcester
- UMass Memorial Health, Worcester
Recruiting
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07779707The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With Antidepressant Response in Bipolar Depression
- Massachusetts General Hospital, Boston
RecruitingPhase 4
Ages 18 to 65 · All sexes · Updated Sep 11, 2026 · NCT07699445A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With Depression
- Massachusetts General Hospital, Chelsea, Chelsea
RecruitingPhase 1/2
Ages 18 to 64 · All sexes · Updated Sep 10, 2026 · NCT06597695Modulating Exercise Dosage to Improve Concussion Recovery
- Boston Children's Hospital, Boston
- Spaulding Rehabilitation Hospital, Cambridge
RecruitingPhase 1/2
Ages 13 to 18 · All sexes · Updated Aug 31, 2026 · NCT05434130Study on Allopregnanolone and Depression in Women Across the Menopause Transition
- Beth Israel Deaconess Medical Center, Boston
Recruiting
Ages 40 to 60 · Women · Updated Aug 26, 2026 · NCT06238700Mindfulness-based Cognitive Therapy vs the Health Enhancement Program for Chronic Pain and Depression; The Quiet Focus Study
- Massachusetts General Hospital, Boston
Recruiting
Ages 50 to 120 · All sexes · Updated Aug 25, 2026 · NCT07118722Home-Based tDCS Treatment Of Major Depressive Disorder
- Curavit Clinical Research (virtual study site), Boston
Recruiting
Ages 22 to 70 · All sexes · Updated Aug 14, 2026 · NCT06976697Changing Lives and Changing Outcomes-9 at Worcester Recovery Center and Hospital
- Worcester Recovery Center and Hospital, Worcester
Recruiting
Ages 18 and older · All sexes · Updated Aug 12, 2026 · NCT07359157Using Machine Learning to Optimize User Engagement and Clinical Response to Digital Mental Health Interventions
- Center for Anxiety and Related Disorders, Boston
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT05567640Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression
- Massachusetts General Hospital's Depression and Clinical Research program, Boston
- Massachusetts General Hospital, Boston
Recruiting
Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT07563868Neural Mechanisms of Family-Focused Treatment for Youth Depression
- Boston University, Boston
- Athinoula A. Martinos Imaging Center at Massachusetts Institute of Technology, Charlestown
RecruitingHealthy volunteers welcome
Ages 7 to 12 · All sexes · Updated Jul 20, 2026 · NCT06289010Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa
- Boston University, Boston
RecruitingHealthy volunteers welcome
Ages 15 and older · Women · Updated Jul 17, 2026 · NCT05624931Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions
- Massachusetts General Hospital, Boston
Recruiting
Ages 18 and older · Women · Updated Jul 13, 2026 · NCT06557005Comparing the Efficacy of Heated Yoga and Sauna as a Treatment for Depression
- Massachusetts General Hospital, Boston
Recruiting
Ages 18 to 65 · All sexes · Updated Jul 6, 2026 · NCT07082998Integrative Mindfulness-Based Predictive Approach for Chronic Low Back Pain Treatment
- Boston Medical Center, Boston
Recruiting
Ages 18 and older · All sexes · Updated Jun 30, 2026 · NCT06106191Therapy Dog Visits for Patients Hospitalized With Traumatic Injuries
- Boston Medical Center, Trauma Inpatient Service, Boston
Recruiting
Ages 18 and older · All sexes · Updated Jun 16, 2026 · NCT06812247From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.