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Depression clinical trials in Boston, MA
51 studies for Depression are looking for participants at sites in and around Boston (within about 30 miles). Open a study to see who can join and how to contact the study team.
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
RecruitingPhase 3
- Adams Clinical Boston, Boston
RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
RecruitingPhase 2
- Dana Farber Cancer Institute, Boston
A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
RecruitingPhase 2
- Seaport Investigator Site, Boston
The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With Antidepressant Response in Bipolar Depression
RecruitingPhase 4
- Massachusetts General Hospital, Boston
A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With Depression
RecruitingPhase 1/2
- Massachusetts General Hospital, Chelsea, Chelsea · 3 mi away
A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)
RecruitingPhase 3
- Adams Clinical Boston, Boston
A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
RecruitingPhase 2
- Draig Clinical Site, Boston
Modulating Exercise Dosage to Improve Concussion Recovery
RecruitingPhase 1/2
- Boston Children's Hospital, Boston
Study on Allopregnanolone and Depression in Women Across the Menopause Transition
Recruiting
- Beth Israel Deaconess Medical Center, Boston
Mindfulness-based Cognitive Therapy vs the Health Enhancement Program for Chronic Pain and Depression; The Quiet Focus Study
Recruiting
- Massachusetts General Hospital, Boston
Home-Based tDCS Treatment Of Major Depressive Disorder
Recruiting
- Curavit Clinical Research (virtual study site), Boston
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
RecruitingPhase 3
- Adams Clinical Boston, Boston
E-Mindfulness Approaches for Living After Breast Cancer
RecruitingPhase 3
- Tufts Medical Center, Boston
A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder
RecruitingPhase 3
- Boston Clinical Trials Llc, Boston
Using Machine Learning to Optimize User Engagement and Clinical Response to Digital Mental Health Interventions
RecruitingHealthy volunteers welcome
- Center for Anxiety and Related Disorders, Boston
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 3
- Neurocrine Clinical Site, Boston
Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression
Recruiting
- Massachusetts General Hospital's Depression and Clinical Research program, Boston
- Massachusetts General Hospital, Boston
Effects of Intranasal Oxytocin in Patients With Arginine-vasopressin Deficiency
RecruitingPhase 1
- Massachusetts General Hospital, Neuroendocrine Unit, Boston
Neural Mechanisms of Family-Focused Treatment for Youth Depression
RecruitingHealthy volunteers welcome
- Boston University, Boston
- Athinoula A. Martinos Imaging Center at Massachusetts Institute of Technology, Charlestown · 1 mi away
Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa
RecruitingHealthy volunteers welcome
- Boston University, Boston
Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions
Recruiting
- Massachusetts General Hospital, Boston
TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age
RecruitingObservational study
- Massachusetts General Hospital, Boston
Comparing the Efficacy of Heated Yoga and Sauna as a Treatment for Depression
Recruiting
- Massachusetts General Hospital, Boston
Integrative Mindfulness-Based Predictive Approach for Chronic Low Back Pain Treatment
Recruiting
- Boston Medical Center, Boston
Pilot Study of a Behavioral Program for Resident Depression in Skilled Nursing Facilities
Recruiting
- Massachusetts General Hospital, Boston
Therapy Dog Visits for Patients Hospitalized With Traumatic Injuries
Recruiting
- Boston Medical Center, Trauma Inpatient Service, Boston
Training in Evidence-based Treatments in Psycho-Oncology
Recruiting
- Massachusetts General Hospital Cancer Center, Boston
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Recruiting
- Massachusetts General Hospital, Boston
Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness
Recruiting
- Massachusetts General Hospital, Boston
Teenthrive 2: Treatments for Improving Mood in Teens
Recruiting
- Beth Israel Deaconess Medical Center, Boston
Self-Help Cognitive Processing Therapy (CPT)/Women Veterans Network (WoVeN) Study
Recruiting
- Fully online study, Boston
Mechanisms Of Orbitofrontal Stimulation in Depression
Recruiting
- Beth Israel Deaconess Medical Center, Boston
Buspirone and Melatonin for Depression Following Traumatic Brain Injury
RecruitingPhase 4
- Massachusetts General Hospital, Boston
- Massachusetts General Hospital Home Base Program, Charlestown · 1 mi away
REVEAL Study - Diagnostic Testing for PTSD Using the Senseye Diagnostic Tool
RecruitingPhase 3Healthy volunteers welcome
- Lindus Health (Virtual Study Site), Boston
Cannabis, Linked Emotions, and Adolescent Risk Study
Recruiting
- Massachusetts General Hopsital, Boston
Cannabidiol for Reduction of Brain Neuroinflammation
RecruitingPhase 2
- Massachusetts General Hospital, Boston
Expressive Writing on Minority Stressors Among Sexual Minority Veterans
Recruiting
- VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston
Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression
RecruitingPhase 4
- Massachusetts General Hospital, Boston
Building Connections
Recruiting
- Disparities Research Unit, Massachusetts General Hospital, Boston
Behavioral Health Program for Short-Stay Nursing Facility Residents & Care Partners
Recruiting
- Massachusetts General Hospital, Boston
Telemedicine-Delivered Unified Protocol for Cognitive Behavioral Therapy for Anxiety and Depression
Recruiting
- Boston University, Boston
Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 3
- Neurocrine Clinical Site, Boston
Mind-body Resilience Program for Cardiac Arrest Survivors and Their Caregivers: Recovering Together After Cardiac Arrest
Recruiting
- Massachusetts General Hospital, Boston
Foundational Programs to Combat Clinician Stress
RecruitingHealthy volunteers welcome
- Massachusetts General Hospital, Boston
Testing "Doula Link", a Multi-Component Intervention to Improve Perinatal Mental Health
RecruitingHealthy volunteers welcome
- Beth Israel Deaconess Medical Center, Boston
RISE Versus Advocacy-based Enhanced Care as Usual for Patients Experiencing IPV
Recruiting
- VA Boston Healthcare System, Boston
Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV
RecruitingPhase 2
- Massachusetts General Hospital, Boston
Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab
RecruitingPhase 2
- Massachusetts General Hospital, Boston
Brain Connectivity in Depression
Recruiting
- Brigham and Women's Hospital, Boston
- Massachusetts General Hospital, Boston
A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
RecruitingPhase 4
- Clinical Research Site, Boston
Peripheral Neuroimmune Mechanisms of Hyperthermia
Recruiting
- Massachusetts General Hospital Depression Clinical & Research Program, Boston
About Depression
Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.
More about Depression on MedlinePlus
Depression trials in other cities
- New York City, NY46 studies
- Philadelphia, PA24 studies
- Chicago, IL23 studies
- Pittsburgh, PA22 studies
- Atlanta, GA22 studies
- San Diego, CA21 studies
- Charleston, SC19 studies
- Houston, TX18 studies
- Los Angeles, CA17 studies
- Orlando, FL17 studies
- Miami, FL16 studies
- Durham, NC15 studies
Other studies in Boston
- Breast Cancer110 studies
- Non-Small Cell Lung Cancer89 studies
- Cancer (all types)86 studies
- Colorectal Cancer63 studies
- Metastatic Cancer63 studies
- Ovarian Cancer62 studies
- Lung Cancer62 studies
- Prostate Cancer61 studies
- Endometrial Cancer50 studies
- Acute Myeloid Leukemia45 studies
- Pancreatic Cancer44 studies
- Heart Failure43 studies
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.