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Depression clinical trials in Boston, MA

51 studies for Depression are looking for participants at sites in and around Boston (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

RecruitingPhase 3
  • Adams Clinical Boston, Boston
Ages 18 to 85 · All sexes · Updated Sep 25, 2026 · NCT06793397

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

RecruitingPhase 2
  • Dana Farber Cancer Institute, Boston
Ages 18 to 80 · All sexes · Updated Sep 15, 2026 · NCT07002034

A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)

RecruitingPhase 2
  • Seaport Investigator Site, Boston
Ages 18 to 65 · All sexes · Updated Sep 14, 2026 · NCT07065240

The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With Antidepressant Response in Bipolar Depression

RecruitingPhase 4
  • Massachusetts General Hospital, Boston
Ages 18 to 65 · All sexes · Updated Sep 11, 2026 · NCT07699445

A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With Depression

RecruitingPhase 1/2
  • Massachusetts General Hospital, Chelsea, Chelsea · 3 mi away
Ages 18 to 64 · All sexes · Updated Sep 10, 2026 · NCT06597695

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)

RecruitingPhase 3
  • Adams Clinical Boston, Boston
Ages 18 to 74 · All sexes · Updated Sep 8, 2026 · NCT07076407

A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression

RecruitingPhase 2
  • Draig Clinical Site, Boston
Ages 18 to 75 · All sexes · Updated Sep 2, 2026 · NCT07610473

Modulating Exercise Dosage to Improve Concussion Recovery

RecruitingPhase 1/2
  • Boston Children's Hospital, Boston
Ages 13 to 18 · All sexes · Updated Aug 31, 2026 · NCT05434130

Study on Allopregnanolone and Depression in Women Across the Menopause Transition

Recruiting
  • Beth Israel Deaconess Medical Center, Boston
Ages 40 to 60 · Women · Updated Aug 26, 2026 · NCT06238700

Mindfulness-based Cognitive Therapy vs the Health Enhancement Program for Chronic Pain and Depression; The Quiet Focus Study

Recruiting
  • Massachusetts General Hospital, Boston
Ages 50 to 120 · All sexes · Updated Aug 25, 2026 · NCT07118722

Home-Based tDCS Treatment Of Major Depressive Disorder

Recruiting
  • Curavit Clinical Research (virtual study site), Boston
Ages 22 to 70 · All sexes · Updated Aug 14, 2026 · NCT06976697

A Study of Brenipatide in Adult Participants With Major Depressive Disorder

RecruitingPhase 3
  • Adams Clinical Boston, Boston
Ages 18 to 75 · All sexes · Updated Aug 6, 2026 · NCT07412756

E-Mindfulness Approaches for Living After Breast Cancer

RecruitingPhase 3
  • Tufts Medical Center, Boston
Ages 18 to 50 · All sexes · Updated Aug 4, 2026 · NCT06748222

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder

RecruitingPhase 3
  • Boston Clinical Trials Llc, Boston
Ages 18 to 74 · All sexes · Updated Aug 3, 2026 · NCT06775379

Using Machine Learning to Optimize User Engagement and Clinical Response to Digital Mental Health Interventions

RecruitingHealthy volunteers welcome
  • Center for Anxiety and Related Disorders, Boston
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT05567640

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Boston
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401

Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression

Recruiting
  • Massachusetts General Hospital's Depression and Clinical Research program, Boston
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT07563868

Effects of Intranasal Oxytocin in Patients With Arginine-vasopressin Deficiency

RecruitingPhase 1
  • Massachusetts General Hospital, Neuroendocrine Unit, Boston
Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT04789148

Neural Mechanisms of Family-Focused Treatment for Youth Depression

RecruitingHealthy volunteers welcome
  • Boston University, Boston
  • Athinoula A. Martinos Imaging Center at Massachusetts Institute of Technology, Charlestown · 1 mi away
Ages 7 to 12 · All sexes · Updated Jul 20, 2026 · NCT06289010

Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa

RecruitingHealthy volunteers welcome
  • Boston University, Boston
Ages 15 and older · Women · Updated Jul 17, 2026 · NCT05624931

Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions

Recruiting
  • Massachusetts General Hospital, Boston
Ages 18 and older · Women · Updated Jul 13, 2026 · NCT06557005

TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age

RecruitingObservational study
  • Massachusetts General Hospital, Boston
18 Months – 11 Years · All sexes · Updated Jul 6, 2026 · NCT07048574

Comparing the Efficacy of Heated Yoga and Sauna as a Treatment for Depression

Recruiting
  • Massachusetts General Hospital, Boston
Ages 18 to 65 · All sexes · Updated Jul 6, 2026 · NCT07082998

Integrative Mindfulness-Based Predictive Approach for Chronic Low Back Pain Treatment

Recruiting
  • Boston Medical Center, Boston
Ages 18 and older · All sexes · Updated Jun 30, 2026 · NCT06106191

Pilot Study of a Behavioral Program for Resident Depression in Skilled Nursing Facilities

Recruiting
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Jun 17, 2026 · NCT07655232

Therapy Dog Visits for Patients Hospitalized With Traumatic Injuries

Recruiting
  • Boston Medical Center, Trauma Inpatient Service, Boston
Ages 18 and older · All sexes · Updated Jun 16, 2026 · NCT06812247

Training in Evidence-based Treatments in Psycho-Oncology

Recruiting
  • Massachusetts General Hospital Cancer Center, Boston
Ages 18 and older · All sexes · Updated Jun 15, 2026 · NCT05674357

Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness

Recruiting
  • Massachusetts General Hospital, Boston
Ages 14 to 19 · All sexes · Updated Jun 11, 2026 · NCT05962879

Teenthrive 2: Treatments for Improving Mood in Teens

Recruiting
  • Beth Israel Deaconess Medical Center, Boston
Ages 12 to 18 · All sexes · Updated Jun 10, 2026 · NCT07475845

Self-Help Cognitive Processing Therapy (CPT)/Women Veterans Network (WoVeN) Study

Recruiting
  • Fully online study, Boston
Ages 18 and older · Women · Updated May 27, 2026 · NCT07250061

Mechanisms Of Orbitofrontal Stimulation in Depression

Recruiting
  • Beth Israel Deaconess Medical Center, Boston
Ages 18 to 65 · All sexes · Updated May 14, 2026 · NCT07230990

Buspirone and Melatonin for Depression Following Traumatic Brain Injury

RecruitingPhase 4
  • Massachusetts General Hospital, Boston
  • Massachusetts General Hospital Home Base Program, Charlestown · 1 mi away
Ages 18 to 64 · All sexes · Updated May 6, 2026 · NCT04400266

REVEAL Study - Diagnostic Testing for PTSD Using the Senseye Diagnostic Tool

RecruitingPhase 3Healthy volunteers welcome
  • Lindus Health (Virtual Study Site), Boston
Ages 18 and older · All sexes · Updated Apr 29, 2026 · NCT07280065

Cannabis, Linked Emotions, and Adolescent Risk Study

Recruiting
  • Massachusetts General Hopsital, Boston
Ages 12 to 18 · All sexes · Updated Mar 3, 2026 · NCT06576076

Cannabidiol for Reduction of Brain Neuroinflammation

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
Ages 18 to 75 · All sexes · Updated Feb 6, 2026 · NCT05066308

Expressive Writing on Minority Stressors Among Sexual Minority Veterans

Recruiting
  • VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston
Ages 18 and older · All sexes · Updated Feb 2, 2026 · NCT05897021

Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression

RecruitingPhase 4
  • Massachusetts General Hospital, Boston
Ages 18 to 70 · All sexes · Updated Dec 12, 2025 · NCT05450432

Building Connections

Recruiting
  • Disparities Research Unit, Massachusetts General Hospital, Boston
Ages 18 to 75 · All sexes · Updated Nov 18, 2025 · NCT07091032

Behavioral Health Program for Short-Stay Nursing Facility Residents & Care Partners

Recruiting
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Nov 10, 2025 · NCT07220486

Telemedicine-Delivered Unified Protocol for Cognitive Behavioral Therapy for Anxiety and Depression

Recruiting
  • Boston University, Boston
Ages 18 to 64 · All sexes · Updated Oct 30, 2025 · NCT05734313

Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Boston
Ages 18 and older · All sexes · Updated Oct 29, 2025 · NCT06786624

Mind-body Resilience Program for Cardiac Arrest Survivors and Their Caregivers: Recovering Together After Cardiac Arrest

Recruiting
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Oct 23, 2025 · NCT07143357

Foundational Programs to Combat Clinician Stress

RecruitingHealthy volunteers welcome
  • Massachusetts General Hospital, Boston
Ages 25 to 70 · All sexes · Updated Oct 23, 2025 · NCT07220421

Testing "Doula Link", a Multi-Component Intervention to Improve Perinatal Mental Health

RecruitingHealthy volunteers welcome
  • Beth Israel Deaconess Medical Center, Boston
All ages · All sexes · Updated Oct 22, 2025 · NCT07217561

RISE Versus Advocacy-based Enhanced Care as Usual for Patients Experiencing IPV

Recruiting
  • VA Boston Healthcare System, Boston
Ages 18 and older · All sexes · Updated Oct 14, 2025 · NCT06906302

Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
Ages 18 to 85 · All sexes · Updated Sep 12, 2025 · NCT05570812

Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
Ages 25 to 50 · All sexes · Updated May 7, 2025 · NCT06136546

Brain Connectivity in Depression

Recruiting
  • Brigham and Women's Hospital, Boston
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Apr 21, 2025 · NCT03276793

A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

RecruitingPhase 4
  • Clinical Research Site, Boston
Ages 18 to 65 · All sexes · Updated Jan 23, 2025 · NCT06223880

Peripheral Neuroimmune Mechanisms of Hyperthermia

Recruiting
  • Massachusetts General Hospital Depression Clinical & Research Program, Boston
Ages 18 to 65 · All sexes · Updated Mar 10, 2023 · NCT05366270

About Depression

Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.

More about Depression on MedlinePlus

Depression trials in other cities

Other studies in Boston

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.