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Depression clinical trials in Pennsylvania
46 studies for Depression are looking for participants at sites in Pennsylvania.
Cities in Pennsylvania
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
- Adams Clinical Philadelphia, Philadelphia
- Flourish Research Philadelphia, Philadelphia
RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Nov 13, 2026 · NCT06793397Precision Depression Adalimumab Trial
- University of Pennsylvania, Philadelphia
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07845604RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
- University of Pennsylvania, Philadelphia
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Nov 10, 2026 · NCT07002034A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
- Seaport Investigator Site, Allentown
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Nov 10, 2026 · NCT07065240A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
- Scranton Medical Institutes, Moosic
Recruiting
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT03887715E-Mindfulness Approaches for Living After Breast Cancer
- Carlisle Regional Cancer Center, Carlisle
- WellSpan Medical Oncology and Hematology, Chambersburg
- Geisinger Medical Center, Danville
- and 28 more
RecruitingPhase 3
Ages 18 to 50 · All sexes · Updated Nov 4, 2026 · NCT06748222A Study of Brenipatide in Adult Participants With Major Depressive Disorder
- Penn Medicine: University of Pennsylvania Health System, Philadelphia
- Suburban Research Associates, West Chester
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Nov 4, 2026 · NCT07412756A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
- Adams Clinical Philadelphia, Philadelphia
- Penn Medicine: University of Pennsylvania Health System, Philadelphia
- Suburban Research Associates, West Chester
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Nov 3, 2026 · NCT07775300Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Philadelphia
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT06966401Risk and Resilience to Suicide Following Late-Life Spousal Bereavement
- University of Pittsburgh (UPMC), Pittsburgh
Recruiting
Ages 60 and older · All sexes · Updated Oct 30, 2026 · NCT06191484Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression
- Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, Philadelphia
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Oct 23, 2026 · NCT07226232Evaluation of the PACE/PACENET BHL Clinical Program
- Department of Psychiatry (Center for Psychotherapy Research), University of Pennsylvania, Philadelphia
RecruitingObservational study
Ages 65 and older · All sexes · Updated Oct 22, 2026 · NCT02463266Morphine or Ketamine for Analgesia
- UPMC Children's Hospital of Pittsburgh, Pittsburgh
RecruitingPhase 3
Ages 6 to 17 · All sexes · Updated Oct 20, 2026 · NCT06835504Development of a College Student-Delivered Cognitive-Behavioral Therapy (CBT) Intervention for Rural High School Students
- Penn State College of Medicine, Hershey
Recruiting
Ages 13 to 18 · All sexes · Updated Oct 20, 2026 · NCT07240792A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
- Draig Clinical Site, Allentown
- Draig Clinical Site, Media
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Oct 14, 2026 · NCT07610473Rapid Antidepressant Dynamics in Acute Neuromodulation Treatments
- Bellefield Towers, Pittsburgh
Recruiting
Ages 18 to 55 · All sexes · Updated Oct 13, 2026 · NCT06976840RISE Versus Advocacy-based Enhanced Care as Usual for Patients Experiencing IPV
- VA Philadelphia Healthcare System, Philadelphia
Recruiting
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT06906302Confirmatory Efficacy of the Building a Strong Identity and Coping Skills Program
- Pennsylvania Psychiatric Institute, Harrisburg
- Penn State Health Medical Group - Psychiatry and Behavioral Health, Hershey
- Penns Valley Area School District, Spring Mills
- and 2 more
RecruitingHealthy volunteers welcome
Ages 11 and older · All sexes · Updated Sep 17, 2026 · NCT05789446Acoustic Stimulation, Sleep, and Cognitive-Emotional Processes in Young Adults With Anxiety and Depression Symptoms
- University of Pittsburgh, Pittsburgh
Recruiting
Ages 18 to 25 · All sexes · Updated Sep 16, 2026 · NCT05802004Decoding and Modulating Affective Brain States
- University of Pennsylvania, Philadelphia
RecruitingMentions payment for participants
Ages 18 to 65 · All sexes · Updated Sep 3, 2026 · NCT05437705Technology Assisted Collaborative Care Intervention to Improve Patient-centered Outcomes in Dialysis Patients
- University of Pittsburgh, Pittsburgh
Recruiting
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT06978127A Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents
- STAR Center, Western Psychiatric Institute & Clinic, Pittsburgh
- University of Pittsburgh, Pittsburgh
Recruiting
Ages 13 to 24 · All sexes · Updated Aug 12, 2026 · NCT07348666Apimostinel + Automated Neurocognitive Training for Depression
- Western Psychiatric Institute and Clinic, Pittsburgh
RecruitingPhase 2
Ages 18 to 60 · All sexes · Updated Aug 10, 2026 · NCT06400121NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Philadelphia
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT06963021Sleep and Circadian Interventions for College Students at High Risk of Suicide
- Western Psychiatric Hospital/University of Pittsburgh, Pittsburgh
Recruiting
Ages 18 to 25 · All sexes · Updated Jul 7, 2026 · NCT07346014Transdiagnostic Sleep and Circadian Intervention + Bright Light in Adolescents With Elevated Depression (TranS-C+BL)
- Childrens Hospital of Philadelphia, Philadelphia
- University of Pittsburgh, Pittsburgh
Recruiting
Ages 12 to 18 · All sexes · Updated Jun 4, 2026 · NCT06963463Get ActivE Study for At-risk Youth
- Children's Hospital of Philadelphia, Philadelphia
- University of Pittsburgh Medical Center, Pittsburgh
Recruiting
Ages 12 to 18 · All sexes · Updated Jun 4, 2026 · NCT06829953RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty
- UPMC East, Monroeville
- UPMC Shadyside, Pittsburgh
- UPMC Passavant, Pittsburgh
Recruiting
Ages 18 to 100 · All sexes · Updated Jun 3, 2026 · NCT05658796Sparrow Link Neuromodulation Device for Opioid Withdrawal Management in Hospitalized Adults With Opioid Use Disorder
- UPMC Presbyterian, Pittsburgh
Recruiting
Ages 18 and older · All sexes · Updated Jun 1, 2026 · NCT07079826Telehealth Collaborative Care Model (CoCM) in Lung Cancer
- Abramson Cancer Center at the University of Pennsylvania, Philadelphia
Recruiting
Ages 18 and older · All sexes · Updated May 28, 2026 · NCT07102147Caregiver Stress and Sleep Study
- UPMC Western Behavioral Health, Pittsburgh
RecruitingHealthy volunteers welcome
Ages 55 and older · All sexes · Updated May 19, 2026 · NCT05219955Assessing Improvements in Mood and Sleep Trial
- University of Pittsburgh, Pittsburgh
Recruiting
Ages 55 and older · All sexes · Updated May 19, 2026 · NCT06639477Teen Brain Online II: Understanding How Social Media Affects the Teen Brain
- University of Pittsburgh, Pittsburgh
Recruiting
Ages 13 to 17 · All sexes · Updated May 6, 2026 · NCT06817993Retrospective Analyses of the Greenbrook Database Evaluating Mental Health Treatments
- Neuronetics, Malvern
RecruitingObservational study
Ages 5 to 100 · All sexes · Updated Apr 9, 2026 · NCT06997549Retrospective Analyses of TrakStar Database
- Neuronetics, Malvern
RecruitingObservational study
Ages 5 to 120 · All sexes · Updated Apr 9, 2026 · NCT06917339Preoperative Opioid Tapering Before Spine Surgery
- Thomas Jefferson University Hospital, Philadephia
Recruiting
Ages 18 and older · All sexes · Updated Mar 24, 2026 · NCT07221786Amygdala Neurofeedback for Depression - Large Scale Clinical Trial
- University of Pittsburgh, Pittsburgh
Recruiting
Ages 18 to 55 · All sexes · Updated Mar 4, 2026 · NCT05703256Green Light for Post-Operative Wellness
- UPMC Shadyside Hospital, Pittsburgh
Recruiting
Ages 18 and older · All sexes · Updated Feb 12, 2026 · NCT07218289Impact of Depression on Thermoregulation
- Noll Laboratory, University Park
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 40 · All sexes · Updated Feb 3, 2026 · NCT06805851Parent Encouragement And Coaching of Happiness in Youth
- University of Pittsburgh, Pittsburgh
RecruitingHealthy volunteers welcome
Ages 4 to 99 · All sexes · Updated Jan 28, 2026 · NCT06725160From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.