Home › Depression › Pennsylvania
Depression clinical trials in Pennsylvania
49 studies for Depression are looking for participants at sites in Pennsylvania.
Cities in Pennsylvania
Precision Depression Adalimumab Trial
- University of Pennsylvania, Philadelphia
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07845604A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
- Adams Clinical Philadelphia, Philadelphia
- Flourish Research Philadelphia, Philadelphia
RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Sep 25, 2026 · NCT06793397Confirmatory Efficacy of the Building a Strong Identity and Coping Skills Program
- Pennsylvania Psychiatric Institute, Harrisburg
- Penn State Health Medical Group - Psychiatry and Behavioral Health, Hershey
- Penns Valley Area School District, Spring Mills
- and 2 more
RecruitingHealthy volunteers welcome
Ages 11 and older · All sexes · Updated Sep 17, 2026 · NCT05789446Acoustic Stimulation, Sleep, and Cognitive-Emotional Processes in Young Adults With Anxiety and Depression Symptoms
- University of Pittsburgh, Pittsburgh
Recruiting
Ages 18 to 25 · All sexes · Updated Sep 16, 2026 · NCT05802004RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
- University of Pennsylvania, Philadelphia
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Sep 15, 2026 · NCT07002034A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
- Seaport Investigator Site, Allentown
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Sep 14, 2026 · NCT07065240Decoding and Modulating Affective Brain States
- University of Pennsylvania, Philadelphia
RecruitingMentions payment for participants
Ages 18 to 65 · All sexes · Updated Sep 3, 2026 · NCT05437705A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
- Draig Clinical Site, Allentown
- Draig Clinical Site, Media
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 2, 2026 · NCT07610473A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
- Draig Clinical Site, Media
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Aug 26, 2026 · NCT07300969Technology Assisted Collaborative Care Intervention to Improve Patient-centered Outcomes in Dialysis Patients
- University of Pittsburgh, Pittsburgh
Recruiting
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT06978127Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression
- Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, Philadelphia
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Aug 14, 2026 · NCT07226232A Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents
- STAR Center, Western Psychiatric Institute & Clinic, Pittsburgh
- University of Pittsburgh, Pittsburgh
Recruiting
Ages 13 to 24 · All sexes · Updated Aug 12, 2026 · NCT07348666Apimostinel + Automated Neurocognitive Training for Depression
- Western Psychiatric Institute and Clinic, Pittsburgh
RecruitingPhase 2
Ages 18 to 60 · All sexes · Updated Aug 10, 2026 · NCT06400121NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Philadelphia
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT06963021A Study of Brenipatide in Adult Participants With Major Depressive Disorder
- Suburban Research Associates, Media
- Penn Medicine: University of Pennsylvania Health System, Philadelphia
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Aug 6, 2026 · NCT07412756E-Mindfulness Approaches for Living After Breast Cancer
- Carlisle Regional Cancer Center, Carlisle
- WellSpan Medical Oncology and Hematology, Chambersburg
- Geisinger Medical Center, Danville
- and 28 more
RecruitingPhase 3
Ages 18 to 50 · All sexes · Updated Aug 4, 2026 · NCT06748222A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder
- Lehigh Center For Clinical Research, Allentown
- Adams Clinical - Philadelphia, Philadelphia
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Aug 3, 2026 · NCT06775379Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Philadelphia
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401Sleep and Circadian Interventions for College Students at High Risk of Suicide
- Western Psychiatric Hospital/University of Pittsburgh, Pittsburgh
Recruiting
Ages 18 to 25 · All sexes · Updated Jul 7, 2026 · NCT07346014Improving Mood for Adolescents Through Teaming With End-Users in Routine Care (The iMATTER Project)
- Children's Hospital of Philadelphia, Philadelphia
Recruiting
Ages 13 to 17 · All sexes · Updated Jun 15, 2026 · NCT07020572A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
- Scranton Medical Institutes, Moosic
- University of Pennsylvania, Philadelphia
Recruiting
Ages 18 and older · All sexes · Updated Jun 15, 2026 · NCT03887715Clinical Trial for Integrated Care to Help At Risk Teen (iCHART) Intervention
- Conemaugh Memorial Medical Center-Family Medicine, Johnstown
- CHOP Primary Care, CHOP Campus, Philadelphia
- Roxborough, Philadelphia
- and 9 more
Recruiting
Ages 12 to 18 · All sexes · Updated Jun 4, 2026 · NCT05748730Get ActivE Study for At-risk Youth
- Children's Hospital of Philadelphia, Philadelphia
- University of Pittsburgh Medical Center, Pittsburgh
Recruiting
Ages 12 to 18 · All sexes · Updated Jun 4, 2026 · NCT06829953Transdiagnostic Sleep and Circadian Intervention + Bright Light in Adolescents With Elevated Depression (TranS-C+BL)
- Childrens Hospital of Philadelphia, Philadelphia
- University of Pittsburgh, Pittsburgh
Recruiting
Ages 12 to 18 · All sexes · Updated Jun 4, 2026 · NCT06963463RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty
- UPMC East, Monroeville
- UPMC Shadyside, Pittsburgh
- UPMC Passavant, Pittsburgh
Recruiting
Ages 18 to 100 · All sexes · Updated Jun 3, 2026 · NCT05658796Sparrow Link Neuromodulation Device for Opioid Withdrawal Management in Hospitalized Adults With Opioid Use Disorder
- UPMC Presbyterian, Pittsburgh
Recruiting
Ages 18 and older · All sexes · Updated Jun 1, 2026 · NCT07079826Telehealth Collaborative Care Model (CoCM) in Lung Cancer
- Abramson Cancer Center at the University of Pennsylvania, Philadelphia
Recruiting
Ages 18 and older · All sexes · Updated May 28, 2026 · NCT07102147Rapid Antidepressant Dynamics in Acute Neuromodulation Treatments
- Bellefield Towers, Pittsburgh
Recruiting
Ages 18 to 55 · All sexes · Updated May 22, 2026 · NCT06976840Assessing Improvements in Mood and Sleep Trial
- University of Pittsburgh, Pittsburgh
Recruiting
Ages 55 and older · All sexes · Updated May 19, 2026 · NCT06639477Caregiver Stress and Sleep Study
- UPMC Western Behavioral Health, Pittsburgh
RecruitingHealthy volunteers welcome
Ages 55 and older · All sexes · Updated May 19, 2026 · NCT05219955A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
- Scranton Medical Institute, LLC, Moosic
- University of Pennsylvania, Philadelphia
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated May 11, 2026 · NCT06524830Teen Brain Online II: Understanding How Social Media Affects the Teen Brain
- University of Pittsburgh, Pittsburgh
Recruiting
Ages 13 to 17 · All sexes · Updated May 6, 2026 · NCT06817993Development of a College Student-Delivered Cognitive-Behavioral Therapy (CBT) Intervention for Rural High School Students
- Penn State College of Medicine, Hershey
Recruiting
Ages 13 to 18 · All sexes · Updated Apr 15, 2026 · NCT07240792Retrospective Analyses of the Greenbrook Database Evaluating Mental Health Treatments
- Neuronetics, Malvern
RecruitingObservational study
Ages 5 to 100 · All sexes · Updated Apr 9, 2026 · NCT06997549Retrospective Analyses of TrakStar Database
- Neuronetics, Malvern
RecruitingObservational study
Ages 5 to 120 · All sexes · Updated Apr 9, 2026 · NCT06917339Preoperative Opioid Tapering Before Spine Surgery
- Thomas Jefferson University Hospital, Philadephia
Recruiting
Ages 18 and older · All sexes · Updated Mar 24, 2026 · NCT07221786Amygdala Neurofeedback for Depression - Large Scale Clinical Trial
- University of Pittsburgh, Pittsburgh
Recruiting
Ages 18 to 55 · All sexes · Updated Mar 4, 2026 · NCT05703256Green Light for Post-Operative Wellness
- UPMC Shadyside Hospital, Pittsburgh
Recruiting
Ages 18 and older · All sexes · Updated Feb 12, 2026 · NCT07218289Impact of Depression on Thermoregulation
- Noll Laboratory, University Park
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 40 · All sexes · Updated Feb 3, 2026 · NCT06805851Parent Encouragement And Coaching of Happiness in Youth
- University of Pittsburgh, Pittsburgh
RecruitingHealthy volunteers welcome
Ages 4 to 99 · All sexes · Updated Jan 28, 2026 · NCT06725160From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.