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Depression clinical trials in Pittsburgh, PA

22 studies for Depression are looking for participants at sites in and around Pittsburgh (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

E-Mindfulness Approaches for Living After Breast Cancer

RecruitingPhase 3
  • UPMC-Magee Womens Hospital, Pittsburgh
  • UPMC-Saint Margaret, Pittsburgh
  • UPMC Hillman Cancer Center, Pittsburgh
  • and 2 more
Ages 18 to 50 · All sexes · Updated Nov 4, 2026 · NCT06748222

Risk and Resilience to Suicide Following Late-Life Spousal Bereavement

Recruiting
  • University of Pittsburgh (UPMC), Pittsburgh
Ages 60 and older · All sexes · Updated Oct 30, 2026 · NCT06191484

Morphine or Ketamine for Analgesia

RecruitingPhase 3
  • UPMC Children's Hospital of Pittsburgh, Pittsburgh
Ages 6 to 17 · All sexes · Updated Oct 20, 2026 · NCT06835504

Rapid Antidepressant Dynamics in Acute Neuromodulation Treatments

Recruiting
  • Bellefield Towers, Pittsburgh
Ages 18 to 55 · All sexes · Updated Oct 13, 2026 · NCT06976840

Acoustic Stimulation, Sleep, and Cognitive-Emotional Processes in Young Adults With Anxiety and Depression Symptoms

Recruiting
  • University of Pittsburgh, Pittsburgh
Ages 18 to 25 · All sexes · Updated Sep 16, 2026 · NCT05802004

Technology Assisted Collaborative Care Intervention to Improve Patient-centered Outcomes in Dialysis Patients

Recruiting
  • University of Pittsburgh, Pittsburgh
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT06978127

A Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents

Recruiting
  • STAR Center, Western Psychiatric Institute & Clinic, Pittsburgh
  • University of Pittsburgh, Pittsburgh
Ages 13 to 24 · All sexes · Updated Aug 12, 2026 · NCT07348666

Apimostinel + Automated Neurocognitive Training for Depression

RecruitingPhase 2
  • Western Psychiatric Institute and Clinic, Pittsburgh
Ages 18 to 60 · All sexes · Updated Aug 10, 2026 · NCT06400121

Sleep and Circadian Interventions for College Students at High Risk of Suicide

Recruiting
  • Western Psychiatric Hospital/University of Pittsburgh, Pittsburgh
Ages 18 to 25 · All sexes · Updated Jul 7, 2026 · NCT07346014

Transdiagnostic Sleep and Circadian Intervention + Bright Light in Adolescents With Elevated Depression (TranS-C+BL)

Recruiting
  • University of Pittsburgh, Pittsburgh
Ages 12 to 18 · All sexes · Updated Jun 4, 2026 · NCT06963463

Get ActivE Study for At-risk Youth

Recruiting
  • University of Pittsburgh Medical Center, Pittsburgh
Ages 12 to 18 · All sexes · Updated Jun 4, 2026 · NCT06829953

RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty

Recruiting
  • UPMC Shadyside, Pittsburgh
  • UPMC Passavant, Pittsburgh
  • UPMC East, Monroeville · 11 mi away
Ages 18 to 100 · All sexes · Updated Jun 3, 2026 · NCT05658796

Sparrow Link Neuromodulation Device for Opioid Withdrawal Management in Hospitalized Adults With Opioid Use Disorder

Recruiting
  • UPMC Presbyterian, Pittsburgh
Ages 18 and older · All sexes · Updated Jun 1, 2026 · NCT07079826

Caregiver Stress and Sleep Study

RecruitingHealthy volunteers welcome
  • UPMC Western Behavioral Health, Pittsburgh
Ages 55 and older · All sexes · Updated May 19, 2026 · NCT05219955

Assessing Improvements in Mood and Sleep Trial

Recruiting
  • University of Pittsburgh, Pittsburgh
Ages 55 and older · All sexes · Updated May 19, 2026 · NCT06639477

Teen Brain Online II: Understanding How Social Media Affects the Teen Brain

Recruiting
  • University of Pittsburgh, Pittsburgh
Ages 13 to 17 · All sexes · Updated May 6, 2026 · NCT06817993

Amygdala Neurofeedback for Depression - Large Scale Clinical Trial

Recruiting
  • University of Pittsburgh, Pittsburgh
Ages 18 to 55 · All sexes · Updated Mar 4, 2026 · NCT05703256

Green Light for Post-Operative Wellness

Recruiting
  • UPMC Shadyside Hospital, Pittsburgh
Ages 18 and older · All sexes · Updated Feb 12, 2026 · NCT07218289

Parent Encouragement And Coaching of Happiness in Youth

RecruitingHealthy volunteers welcome
  • University of Pittsburgh, Pittsburgh
Ages 4 to 99 · All sexes · Updated Jan 28, 2026 · NCT06725160

Bright Light Therapy for OSA

Recruiting
  • VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh
Ages 40 to 65 · All sexes · Updated Jan 9, 2026 · NCT05917119

Fear of Recurrence and Stopping Immunotherapy

Recruiting
  • UPMC Hillman Cancer Centers, Pittsburgh
Ages 21 and older · All sexes · Updated Dec 5, 2025 · NCT04761328

Preventing Suicide Among Sexual and Gender Diverse Young Adults in Primary Care

Recruiting
  • University of Pittsburgh, Pittsburgh
Ages 18 to 24 · All sexes · Updated Nov 6, 2025 · NCT05869552

About Depression

Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.

More about Depression on MedlinePlus

Depression trials in other cities

Other studies in Pittsburgh

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.