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Depression clinical trials in Philadelphia, PA
21 studies for Depression are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.
Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
RecruitingPhase 3
- Adams Clinical Philadelphia, Philadelphia
- Flourish Research Philadelphia, Philadelphia
Precision Depression Adalimumab Trial
RecruitingPhase 2
- University of Pennsylvania, Philadelphia
RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
RecruitingPhase 2
- University of Pennsylvania, Philadelphia
E-Mindfulness Approaches for Living After Breast Cancer
RecruitingPhase 3
- UPMC Hillman Cancer Center - Part of Frick Hospital, Mount Pleasant · 8 mi away
- Chester County Hospital, West Chester · 24 mi away
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
RecruitingPhase 3
- Penn Medicine: University of Pennsylvania Health System, Philadelphia
- Suburban Research Associates, West Chester · 24 mi away
A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
RecruitingPhase 3
- Adams Clinical Philadelphia, Philadelphia
- Penn Medicine: University of Pennsylvania Health System, Philadelphia
- Suburban Research Associates, West Chester · 24 mi away
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 3
- Neurocrine Clinical Site, Philadelphia
Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression
RecruitingPhase 3
- Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, Philadelphia
Evaluation of the PACE/PACENET BHL Clinical Program
RecruitingObservational study
- Department of Psychiatry (Center for Psychotherapy Research), University of Pennsylvania, Philadelphia
Morphine or Ketamine for Analgesia
RecruitingPhase 3
- Nemours Children's Hospital, Wilmington · 25 mi away
A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
RecruitingPhase 2
- Draig Clinical Site, Media · 12 mi away
RISE Versus Advocacy-based Enhanced Care as Usual for Patients Experiencing IPV
Recruiting
- VA Philadelphia Healthcare System, Philadelphia
Decoding and Modulating Affective Brain States
RecruitingMentions payment for participants
- University of Pennsylvania, Philadelphia
NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 3
- Neurocrine Clinical Site, Philadelphia
Transdiagnostic Sleep and Circadian Intervention + Bright Light in Adolescents With Elevated Depression (TranS-C+BL)
Recruiting
- Childrens Hospital of Philadelphia, Philadelphia
Get ActivE Study for At-risk Youth
Recruiting
- Children's Hospital of Philadelphia, Philadelphia
Telehealth Collaborative Care Model (CoCM) in Lung Cancer
Recruiting
- Abramson Cancer Center at the University of Pennsylvania, Philadelphia
Retrospective Analyses of the Greenbrook Database Evaluating Mental Health Treatments
RecruitingObservational study
- Neuronetics, Malvern · 19 mi away
Retrospective Analyses of TrakStar Database
RecruitingObservational study
- Neuronetics, Malvern · 19 mi away
Antidepressant Adherence for Depressed Adults in Primary Care
Recruiting
- University of Pennsylvania Health System, Philadelphia
Foundational Programs to Combat Clinician Stress
RecruitingHealthy volunteers welcome
- Hospital of the University of Pennsylvania, Philadelphia
- Penn Presbyterian Medical Center, Philadelphia
- Pennsylvania Hospital, Philadelphia
About Depression
Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.
More about Depression on MedlinePlus
Depression trials in other cities
- Boston, MA50 studies
- New York City, NY44 studies
- Chicago, IL26 studies
- Atlanta, GA22 studies
- Pittsburgh, PA22 studies
- Charleston, SC18 studies
- San Diego, CA18 studies
- Houston, TX18 studies
- Los Angeles, CA17 studies
- Washington, DC16 studies
- San Francisco, CA15 studies
- Orlando, FL15 studies
Other studies in Philadelphia
- Cancer (all types)57 studies
- Breast Cancer51 studies
- Non-Small Cell Lung Cancer49 studies
- Ovarian Cancer47 studies
- Metastatic Cancer42 studies
- Colorectal Cancer41 studies
- Prostate Cancer41 studies
- Lung Cancer36 studies
- Acute Myeloid Leukemia33 studies
- Heart Failure31 studies
- Endometrial Cancer29 studies
- Pancreatic Cancer26 studies
From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.