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Endometrial Cancer clinical trials in Philadelphia, PA

28 studies for Endometrial Cancer are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

RecruitingPhase 3

Thomas Jefferson University Hospital, Philadelphia
Jefferson Torresdale Hospital, Philadelphia
Asplundh Cancer Pavilion, Willow Grove · 13 mi away

Ages 18 and older · Women · Updated Oct 5, 2026 · NCT07198074

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

RecruitingPhase 2

Pennsylvania Hospital, Philadelphia
Thomas Jefferson University Hospital, Philadelphia
Fox Chase Cancer Center, Philadelphia
and 4 more

All ages · All sexes · Updated Oct 5, 2026 · NCT05564377

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2

Abramson Cancer Center of the University of Pennsylvania, Philadelphia

Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

Testing Different Amounts of the Combination of Drugs M1774 and ZEN-3694 for the Treatment of Recurrent Ovarian and Endometrial Cancer

RecruitingPhase 1

NRG Oncology, Philadelphia
University of Pennsylvania/Abramson Cancer Center, Philadelphia
Thomas Jefferson University Hospital, Philadelphia

Ages 18 and older · Women · Updated Oct 2, 2026 · NCT05950464

A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors

RecruitingPhase 1

Sidney Kimmell Cancer Center - Jefferson Health, Philadelphia

Ages 19 and older · All sexes · Updated Oct 1, 2026 · NCT06586957

Study of AVZO-021 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2

Avenzo Therapeutics Recruiting Site, Philadelphia

Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT05867251

Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinoma

RecruitingPhase 2

UPMC Hillman Cancer Center - Part of Frick Hospital, Mount Pleasant · 8 mi away

Ages 18 and older · Women · Updated Sep 28, 2026 · NCT05112601

DESTINY-PANTUMOUR04

RecruitingObservational study

Research Site, Philadelphia

Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000

Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

RecruitingPhase 1

Research Site, Philadelphia

Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06218914

Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER

RecruitingPhase 2

Thomas Jefferson University, Philadelphia
Lankenau Medical Center, Wynnewood · 7 mi away
Asplundh Cancer Pavilion, Willow Grove · 13 mi away
and 1 more

Ages 18 and older · Women · Updated Sep 24, 2026 · NCT05640999

A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab

RecruitingPhase 1/2

Perelman School of Medicine at the University of Pennsylvania, Philadelphia

Ages 18 and older · Women · Updated Sep 24, 2026 · NCT04590326

A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

RecruitingPhase 3

Hospital of the University of Pennsylvania ( Site 5007), Philadelphia

Ages 18 and older · Women · Updated Sep 17, 2026 · NCT06952504

PROton Therapy for Post Surgical Treatment of GYNecologic Cancer

RecruitingPhase 2

University of Pennsylvania, Philadelphia

Ages 18 and older · Women · Updated Sep 17, 2026 · NCT05758688

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

RecruitingObservational study

University of Pennsylvania, Philadelphia

Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT05059444

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

RecruitingPhase 3

Research Site, Philadelphia

Ages 18 and older · Women · Updated Sep 3, 2026 · NCT06989112

FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors

RecruitingPhase 1

Thomas Jefferson University, Sidney Kimmel Cancer Center, Philadelphia

Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT07216105

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

RecruitingPhase 1/2

Children's Hospital of Philadelphia, Philadelphia

12 Months – 30 Years · All sexes · Updated Aug 25, 2026 · NCT04851119

A Phase 1 Study of LNCB74 in Advanced Solid Tumors

RecruitingPhase 1

Sidney Kimmel Comprehensive Center at Jefferson, Philadelphia

Ages 18 and older · All sexes · Updated Aug 21, 2026 · NCT06774963

A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas

RecruitingPhase 1/2

Abramson Cancer Center of the University of Pennsylvania, Philadelphia

Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT04104776

A Study of MUC16-Directed Antibody Drug Conjugate HWK-016 in Participants With Advanced Solid Tumors.

RecruitingPhase 1

SCRI - Sydney Kimmel Cancer Center - Jefferson Health, Philadelphia

Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07470853

A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors

RecruitingPhase 1

Normunity Investigational Site, Philadelphia
Normunity Investigational Site, Philadelphia

Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07182149

FOG-001 in Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2

University of Pennsylvania, Perelman School of Medicine, Philadelphia

Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05919264

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2

University of Pennsylvania / Abramson Cancer Center, Philadelphia
Thomas Jefferson University, Sidney Kimmel Cancer Center, Clinical Research Organization, Philadelphia

Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT04657068