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COPD clinical trials in Philadelphia, PA

22 studies for COPD are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.

Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype

RecruitingPhase 3
  • Temple University Hospital- Site Number : 8400059, Philadelphia
Ages 40 to 80 · All sexes · Updated Sep 22, 2026 · NCT07190209

An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema

Recruiting
  • Penn Medicine, Philadelphia
  • Temple University, Philadelphia
Ages 40 to 80 · All sexes · Updated Sep 17, 2026 · NCT06035120

A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease

RecruitingPhase 2
  • Research Site, Philadelphia
  • Research Site, Philadelphia
Ages 40 and older · All sexes · Updated Sep 9, 2026 · NCT07082738

Clinical Trial of Omalizumab for Allergen Sensitized and Exposed Individuals With COPD

RecruitingPhase 2
  • Temple University, Philadelphia
Ages 40 and older · All sexes · Updated Sep 4, 2026 · NCT07059091

A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)

RecruitingPhase 3
  • Research Site, Horsham · 16 mi away
  • Research Site, Wilmington · 25 mi away
Ages 40 to 80 · All sexes · Updated Sep 3, 2026 · NCT06878261

A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)

RecruitingPhase 3
  • Research Site, Philadelphia
Ages 40 to 80 · All sexes · Updated Sep 3, 2026 · NCT06883305

COPD Exacerbation Follow Up

RecruitingObservational study
  • Thomas Jefferson University, Philadelphia
Ages 40 and older · All sexes · Updated Sep 2, 2026 · NCT07118306

A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease

RecruitingPhase 3
  • Research Site, Philadelphia
  • Research Site, Philadelphia
Ages 40 to 80 · All sexes · Updated Aug 26, 2026 · NCT06283966

To Evaluate the Effect of EXPD-101/FXS7553 Compared With Placebo in Patients With COPD Over 52 Weeks of Treatment

RecruitingPhase 2
  • DM Clinical Research - Philadelphia, Philadelphia
Ages 40 to 85 · All sexes · Updated Aug 7, 2026 · NCT07684820

STRIVE Post-Market Registry Study

RecruitingObservational study
  • Temple University, Philadelphia
Ages 18 and older · All sexes · Updated Aug 3, 2026 · NCT04302272

eValuating the Efficacy and Safety of InitiatinG depemokImab earLy therApy iN Chronic Obstructive Pulmonary Disorder (COPD) With Type 2 Inflammation

RecruitingPhase 3
  • GSK Investigational Site, West Chester · 24 mi away
Ages 40 to 75 · All sexes · Updated Jul 28, 2026 · NCT07177339

Closed Loop Oxygen Control in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Nasal High Flow in the Hospital

Recruiting
  • Temple University Hospital, Philadelphia
Ages 22 and older · All sexes · Updated Jun 23, 2026 · NCT07222410

SPIROMICS Study of Early COPD Progression (SOURCE)

RecruitingObservational studyHealthy volunteers welcome
  • Temple University, Philadelphia
Ages 30 to 55 · All sexes · Updated Jun 3, 2026 · NCT05033990

Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD

Recruiting
  • Temple University - Temple Lung Center, Philadelphia
Ages 40 to 80 · All sexes · Updated Apr 28, 2026 · NCT07051707

Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3

Recruiting
  • Temple University, Philadelphia
Ages 40 to 84 · All sexes · Updated Apr 24, 2026 · NCT06891755

Feasibility of Semaglutide in Advanced Lung Disease

RecruitingPhase 1/2
  • University of Pennsylvania Perelman School of Medicine, Philadelphia
Ages 18 to 80 · All sexes · Updated Apr 21, 2026 · NCT05746039

Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)

RecruitingPhase 3
  • GSK Investigational Site, Philadelphia
Ages 40 to 80 · All sexes · Updated Apr 9, 2026 · NCT06961214

Leveraging Lung Cancer Screening to Optimize Screening Outcomes and COPD Management: COPD in LCS Registry

RecruitingObservational study
  • Thomas Jefferson University, Philadelphia
Ages 50 to 80 · All sexes · Updated Mar 3, 2026 · NCT06974981

Supporting Evidence-based Responses to Emotional Needs in Emphysema

Recruiting
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Jan 30, 2026 · NCT06600126

Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening

RecruitingObservational study
  • Temple University, Philadelphia
Ages 50 and older · All sexes · Updated Aug 5, 2025 · NCT06122077

Temple Health Chest Initiative (THCI 2.0)

RecruitingObservational studyHealthy volunteers welcome
  • Temple University Of the Commonwealth System of Higher Education, Philadelphia
Ages 50 to 80 · All sexes · Updated Apr 18, 2025 · NCT06933758

myAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home

Recruiting
  • Jeanes Hospital, Philadelphia
  • Temple University, Philadelphia
Ages 30 and older · All sexes · Updated Feb 6, 2025 · NCT05204888

About COPD

COPD (chronic obstructive pulmonary disease) makes it hard for you to breathe. At first symptoms are mild, but they usually become more severe. Learn more.

More about COPD on MedlinePlus

COPD trials in other cities

Other studies in Philadelphia

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.