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Glioma clinical trials in Durham, NC

12 studies for Glioma are looking for participants at sites in and around Durham (within about 30 miles). Open a study to see who can join and how to contact the study team.

ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas

RecruitingPhase 2
  • Duke University Medical Center, Durham
12 Months – 39 Years · All sexes · Updated Sep 21, 2026 · NCT06838676

Targeted Pediatric High-Grade Glioma Therapy

RecruitingObservational study
  • Duke University Health System, Durham
12 Months – 39 Years · All sexes · Updated Sep 8, 2026 · NCT05839379

Study of Olutasidenib and Temozolomide in HGG

RecruitingPhase 2
  • Duke University Health System, Durham
Ages 12 to 39 · All sexes · Updated Sep 1, 2026 · NCT06161974

SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)

RecruitingPhase 3
  • Duke Cancer Institute, Durham
Ages 18 and older · All sexes · Updated Aug 28, 2026 · NCT05303519

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

RecruitingPhase 2
  • Duke Cancer Center, Durham
Ages 3 to 39 · All sexes · Updated Aug 24, 2026 · NCT05096481

ViCToRy: Vorasidenib in Combination With Tumor Specific Peptide Vaccine for Recurrent IDH1 Mutant Lower Grade Gliomas

RecruitingPhase 1
  • Duke University Medical Center, Durham
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT05609994

Lerapolturev (PVSRIPO) in GBM

RecruitingPhase 2
  • Duke University Medical Center, Durham
Ages 18 and older · All sexes · Updated Jul 20, 2026 · NCT06177964

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

RecruitingEarly phase 1Healthy volunteers welcome
  • Duke University Health System, Durham
Ages 1 to 21 · All sexes · Updated Jun 29, 2026 · NCT06333899

Phase 1 Trial of D2C7-IT in Combination With 2141-V11 for Recurrent Malignant Glioma

RecruitingPhase 1
  • Duke University Medical Center, Durham
Ages 18 and older · All sexes · Updated Jun 4, 2026 · NCT04547777

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

RecruitingPhase 2
  • Duke University Health System, Durham
12 Months – 39 Years · All sexes · Updated May 29, 2026 · NCT05843253

Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of the Oncolytic HSV1 MVR-C5252

RecruitingPhase 1
  • Duke University, Durham
Ages 18 and older · All sexes · Updated Apr 15, 2026 · NCT06126744

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

RecruitingEarly phase 1
  • Duke University Health System, Durham
Up to age 21 · All sexes · Updated Mar 18, 2026 · NCT04655404

Glioma trials in other cities

Other studies in Durham

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.