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Head and Neck Cancer clinical trials in Nashville, TN

21 studies for Head and Neck Cancer are looking for participants at sites in and around Nashville (within about 30 miles). Open a study to see who can join and how to contact the study team.

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The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • Sarah Cannon Research Institute, Nashville
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

RecruitingPhase 2/3
  • Site#0126, Nashville
  • Site #0116, Nashville
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06788990

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • SCRI Oncology Partners, Nashville
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06172478

A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

RecruitingPhase 1
  • Sarah Cannon Research Institute - Pharmacy, Nashville
  • SCRI Oncology Partners, Nashville
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07090499

DESTINY-PANTUMOUR04

RecruitingObservational study
  • Research Site, Nashville
Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000

A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCC

RecruitingPhase 1
  • Sarah Cannon and HCA Research Institute, Nashville
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07462377

Self-Management for Head and Neck Lymphedema and Fibrosis [PROMISE Trial]

Recruiting
  • Barbara Murphy, Nashville
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT06125743

A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • Sarah Cannon Research Institute Oncology Partners (SCRI-Nashville), Nashville
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT05592626

Window Trial of Fluorescently Labeled Panitumumab (Panitumumab-IRDye800) in Head and Neck Cancer

RecruitingPhase 1
  • Vanderbilt University Medical Center, Nashville
Ages 18 and older · All sexes · Updated Aug 3, 2026 · NCT06819228

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • Sarah Cannon Research Institute, Nashville
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT05768139

Safety and Feasibility of Nivolumab-IRDye800CW in Patients With Head and Neck Squamous Cell Carcinoma (HNSCC)

RecruitingPhase 1
  • Vanderbilt University Medical Center, Nashville
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT07460765

Photobiomodulation in Head and Neck Cancer-Related Chronic Lymphedema

Recruiting
  • Vanderbilt University Medical Center, Nashville
Ages 18 and older · All sexes · Updated Jun 23, 2026 · NCT06837480

A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma

RecruitingPhase 3
  • GSK Investigational Site, Nashville
Ages 18 and older · All sexes · Updated May 26, 2026 · NCT06256588

High-Resolution PET-CT Imaging for Surgical Margin Visualization

Recruiting
  • Vanderbilt University Medical Center, Nashville
Ages 18 and older · All sexes · Updated May 8, 2026 · NCT06915454

Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • Sarah Cannon Research Institute, Nashville
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT06239194

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

RecruitingObservational studyHealthy volunteers welcome
  • Vanderbilt-Ingram Cancer Center, Nashville
Ages 40 and older · All sexes · Updated Jan 20, 2026 · NCT05366881

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Nashville
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Tissue Sample Collection From Patients With Head and Neck Cancer and From Healthy Participants

RecruitingObservational studyHealthy volunteers welcome
  • Vanderbilt-Ingram Cancer Center - Cool Springs, Nashville
  • Vanderbilt-Ingram Cancer Center at Franklin, Nashville
  • Veterans Affairs Medical Center - Nashville, Nashville
  • and 1 more
Ages 18 and older · All sexes · Updated Oct 28, 2025 · NCT00898638

A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors

RecruitingPhase 1/2
  • Tennessee Oncology, Nashville
Ages 18 and older · All sexes · Updated Sep 24, 2025 · NCT05941507

Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors

RecruitingPhase 1
  • Vanderbilt University Medical Center, Nashville
Ages 18 and older · All sexes · Updated Aug 15, 2025 · NCT04429542

Gabapentin & Ketamine for Prevention/Treatment of Acute/Chronic Pain in Locally Advanced Head and Neck Cancer

RecruitingPhase 1/2
  • Vanderbilt-Ingram Cancer Center, Nashville
Ages 21 and older · All sexes · Updated Oct 21, 2024 · NCT05156060

About Head and Neck Cancer

Head and neck cancer includes cancers of the mouth, nose, sinuses, salivary glands, throat, and lymph nodes. Read the different symptoms of each type.

More about Head and Neck Cancer on MedlinePlus

Head and Neck Cancer trials in other cities

Other studies in Nashville

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.