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Head and Neck Cancer clinical trials in Chicago, IL

9 studies for Head and Neck Cancer are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • University of Illinois Cancer Center, Chicago
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06172478

A Study Comparing Two Immunotherapy Options for Human Papillomavirus Positive HPV-Positive Head and Neck Cancer After Treatment

RecruitingPhase 2
  • The University of Chicago, Chicago
Ages 18 and older · All sexes · Updated Jul 16, 2026 · NCT07179315

A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

RecruitingPhase 1/2
  • University of Chicago, Chicago
Ages 12 and older · All sexes · Updated May 27, 2026 · NCT03093116

A Study of Pembrolizumab in Combination With Chemotherapy for Head and Neck Cancer

RecruitingPhase 2
  • University of Chicago Comprehensive Cancer Center, Chicago
Ages 18 and older · All sexes · Updated May 12, 2026 · NCT05420948

Dosing Study of Radiation Combined With Tislelizumab and Pamiparib in Patients With Previously Treated Head and Neck Cancer

RecruitingPhase 1
  • The University of Chicago, Chicago
Ages 18 and older · All sexes · Updated Mar 4, 2026 · NCT05526924

Response-Adaptive Treatment in Untreated Locoregional HPV-Negative Head and Neck Cancer

RecruitingPhase 2
  • The University of Chicago, Chicago
Ages 18 and older · All sexes · Updated Mar 4, 2026 · NCT07065630

Dose Finding Study of Zanzalintinib With Pembrolizumab and Cetuximab in Head and Neck SCC

RecruitingPhase 1
  • University of Chicago Medicine Comprehensive Cancer Center, Chicago
Ages 18 and older · All sexes · Updated Dec 2, 2025 · NCT06912087

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Chicago
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Study of RiMO-301 and Radiotherapy With PD-1 Inhibitor for the Treatment of Head-Neck Cancer

RecruitingPhase 1/2
  • University of Illinois at Chicago, Chicago
Ages 18 and older · All sexes · Updated Sep 17, 2025 · NCT05838729

About Head and Neck Cancer

Head and neck cancer includes cancers of the mouth, nose, sinuses, salivary glands, throat, and lymph nodes. Read the different symptoms of each type.

More about Head and Neck Cancer on MedlinePlus

Head and Neck Cancer trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.