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Heart Diseases clinical trials in Boston, MA

14 studies for Heart Diseases are looking for participants at sites in and around Boston (within about 30 miles). Open a study to see who can join and how to contact the study team.

Transition to KPL-387 Monotherapy Dosing & Administration Study

RecruitingPhase 2
  • Investigational Site 043, Boston
Ages 18 to 80 · All sexes · Updated Sep 30, 2026 · NCT07288216

Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting
  • Massachusetts General Hospital, Boston
  • Brigham and Women's Hospital, Boston
  • Beth Israel Deaconess Medical Center, Boston
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT03242642

Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

Recruiting
  • Tufts Medical Center, Boston
  • Massachusetts General Hospital, Boston
Ages 18 to 100 · All sexes · Updated Sep 9, 2026 · NCT06310031

Safety and Performance Assessment of the Sphere-9™ Catheter and Affera™ Ablation System for the Treatment of Ventricular Tachycardia (Sphere-9 VT EFS)

Recruiting
  • Beth Israel Deaconess Medical Center, Boston
Ages 18 to 85 · All sexes · Updated Sep 3, 2026 · NCT06703489

Clinical Course Of Disease In Participants With FA-CM

RecruitingObservational study
  • Boston Children's Hospital, Boston
Ages 6 and older · All sexes · Updated Sep 2, 2026 · NCT06865482

Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

RecruitingPhase 3
  • Massachusetts General Hospital, Boston
  • Brigham and Women's Hospital, Boston
  • Boston University (BU) School of Medicine, Boston
Ages 18 to 75 · All sexes · Updated Aug 4, 2026 · NCT06563895

ELEVATE-HFpEF Clinical Study

Recruiting
  • Tufts Medical Center, Boston
Ages 40 and older · All sexes · Updated Aug 3, 2026 · NCT06678841

PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

Recruiting
  • Tufts Medical Center, Boston
  • Boston Medical Center Corporation, Boston
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05934487

Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

Recruiting
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06526195

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

Recruiting
  • St Elizabeth's Medical Center, Boston
  • Massachusetts General Hospital, Boston
  • Beth Israel Deaconess, Boston
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT03142152

Lumason® Infusion vs. Bolus Administrations

RecruitingPhase 3
  • Beth Israel Deaconess Medical Center, Boston
Ages 18 and older · All sexes · Updated Mar 5, 2026 · NCT06400004

PKP2-ACM Natural History Study

RecruitingObservational study
  • Boston Children's Hospital, Boston
Ages 12 and older · All sexes · Updated Feb 27, 2026 · NCT06644742

PARTNER 3 Trial - Aortic Valve-in-Valve

Recruiting
  • Brigham and Women's Hospital, Boston
All ages · All sexes · Updated May 10, 2024 · NCT03003299

About Heart Diseases

Heart disease is the leading cause of death in the U.S. Learn about the different types of heart diseases, and what you can do to try to prevent them.

More about Heart Diseases on MedlinePlus

Heart Diseases trials in other cities

Other studies in Boston

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.