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Lupus clinical trials recruiting in the U.S.

73 studies for Lupus are recruiting participants at sites across the United States.

Lupus is an autoimmune disease that causes your immune system to attack your healthy tissues and cells. This can cause damage to many parts of your body.

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Recently updated studies

Gonadotropin-releasing Hormone Agonist (GnRHa) in Ovarian Preservation in SLE Subjects Receiving Cyclophosphamide as Determined by Questionnaires

RecruitingObservational study
Ages 18 to 120 · Women · Updated Sep 28, 2026 · NCT05567198

A Study of Nipocalimab in Adults With Moderate to Severe Systemic Lupus Erythematosus

RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Sep 25, 2026 · NCT07438496

CD19-Directed Chimeric Antigen Receptor Autologous T Cells (CART19) for Lupus

RecruitingPhase 1/2
Ages 10 to 29 · All sexes · Updated Sep 24, 2026 · NCT06839976

Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT03816345

The Role of Anifrolumab in Improving Markers of Vascular Risk in Patients With Systemic Lupus Erythematosus (SLE) - IFN-CVD

RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Sep 18, 2026 · NCT05440422

Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants

RecruitingPhase 1
Ages 18 to 65 · All sexes · Updated Sep 18, 2026 · NCT07201558

Anifrolumab Pregnancy Study

RecruitingObservational study
Ages 18 to 130 · Women · Updated Sep 18, 2026 · NCT07049653

A Phase IIa Study of ICG318 CAR-T in Refractory Systemic Lupus Erythematosus With or Without Lupus Nephritis

RecruitingPhase 2
Ages 16 to 70 · All sexes · Updated Sep 17, 2026 · NCT07328581

Transcutaneous Vagus Nerve Stimulation in SLE

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT06987565

A Study to Test Whether Different Doses of BI 3000202 Help People With Systemic Lupus Erythematosus (SLE)

RecruitingPhase 2
Ages 18 to 74 · All sexes · Updated Sep 17, 2026 · NCT07409181

Study of Systemic Lupus Erythematosus

RecruitingObservational studyHealthy volunteers welcome
Ages 3 to 120 · All sexes · Updated Sep 16, 2026 · NCT00001372

Prospective Registry Investigating Maternal, Infant, and Lactation Outcomes in Anifrolumab Users

RecruitingPhase 4
Ages 18 to 130 · Women · Updated Sep 16, 2026 · NCT06594068

HEALTH Home Urinalysis Testing

Recruiting
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT07823478

Dose Escalation Study With Bispecific Antibodies in Adult Participants With Lupus Nephritis

RecruitingPhase 1
Ages 18 to 60 · All sexes · Updated Sep 14, 2026 · NCT06975787

A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease (ELOWEN-2)

RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Sep 14, 2026 · NCT07355218

A Phase 2, Open-Label, Single-Arm Trial of FT819 in Participants With Lupus Nephritis

RecruitingPhase 2
Ages 12 to 70 · All sexes · Updated Sep 14, 2026 · NCT07570862

A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease

RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Sep 11, 2026 · NCT07332481

A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE

RecruitingPhase 1/2
Ages 18 to 70 · All sexes · Updated Sep 10, 2026 · NCT06897930

An Efficacy and Safety Study of Intravenous Anifrolumab to Treat Systemic Lupus Erythematosus in Pediatric Participants

RecruitingPhase 3
Ages 5 to 17 · All sexes · Updated Sep 10, 2026 · NCT05835310

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.