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Major Depressive Disorder clinical trials in California
51 studies for Major Depressive Disorder are looking for participants at sites in California.
Cities in California
- San Diego16 studies
- Orange13 studies
- Glendale12 studies
- Los Angeles12 studies
- Concord12 studies
- Oceanside9 studies
- San Bernardino8 studies
- San Francisco8 studies
- Mountain View7 studies
- San Jose7 studies
- Bellflower6 studies
- Chino6 studies
- Garden Grove4 studies
- Santa Monica4 studies
- Burbank3 studies
- Mission Viejo3 studies
- Long Beach3 studies
- Downey3 studies
- Anaheim3 studies
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
- Behavioral Research Specialists, LLC, Glendale
- CalNeuro Research Group, Los Angeles
- Lipov Medical Group, Los Angeles
- and 4 more
RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Sep 25, 2026 · NCT06793397Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder
- CNRI-Los Angeles, LLC, Pico Rivera
RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Sep 25, 2026 · NCT05850689Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
- PAMOJA Clinical Institute LLC, Anaheim
- Axiom Research, Colton
- Behavioral Research Specialists LLC, Glendale
- and 3 more
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Sep 25, 2026 · NCT06559306A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
- Buena Park Research Center, Buena Park
- Inland Psychiatric Medical Group, Inc. - Chino, Chino
- Synergy Research - San Diego, Lemon Grove
- and 3 more
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07621237Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder
- Vanda Investigational Site, Garden Grove
- Vanda Investigational Site, Orange
- Vanda Investigational Site, Redlands
- and 2 more
RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Sep 24, 2026 · NCT06830044A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
- Neurocrine Clinical Site, Chino
- Neurocrine Clinical Site, Fresno
- Neurocrine Clinical Site, Long Beach
- and 3 more
RecruitingPhase 4
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07105111Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study
- UCSD Interventional Psychiatry, San Diego
Recruiting
Ages 18 to 85 · All sexes · Updated Sep 15, 2026 · NCT07217223A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
- Seaport Investigator Site, Chino
- Seaport Investigator Site, Garden Grove
- Seaport Investigator Site, Glendale
- and 2 more
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Sep 14, 2026 · NCT07065240ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
- Inland Psychiatric Medical Group, Chino
- Behavioral Research Specialists, LLC, Glendale
- Kadima Neuropsychiatry Institute, La Jolla
- and 1 more
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Sep 14, 2026 · NCT07284667Near Infrared Spectroscopy (NIRS) for Assessment of Depression
- San Francisco Veterans Affairs Medical Center, San Francisco
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT04061148A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)
- Clinical Innovations Inc, Bellflower
- Center for Neurohealth, La Jolla
- Artemis Institute for Clinical Research, San Diego
- and 1 more
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Sep 8, 2026 · NCT07076407A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
- Draig Clinical Site, Bellflower
- Draig Clinical Site, Costa Mesa
- Draig Clinical Site, Lafayette
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 2, 2026 · NCT07610473Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
- USC University Hospital, Los Angeles
- UCLA Department of Psychiatry, Los Angeles
- University of California at Davis, Sacramento
Recruiting
Ages 22 to 70 · All sexes · Updated Aug 28, 2026 · NCT06423430A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder
- CI Trials, Bellflower
- Behavioral Research Specialists LLC, Glendale
- Excell Research Inc, Oceanside
- and 3 more
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Aug 28, 2026 · NCT07573176A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
- Draig Clinical Site, Oceanside
- Draig Clinical Site, San Diego
- Draig Clinical Site, Torrance
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Aug 26, 2026 · NCT07300969Virtual Reality-Enhanced Behavioral Activation for Older Adults With Depression
- Stanford University, Stanford
Recruiting
Ages 65 and older · All sexes · Updated Aug 21, 2026 · NCT07188623Enhancing Veteran-Clinical Collaboration in VA PRRCs
- VA San Diego Healthcare System, San Diego, CA, San Diego
- VA Greater Los Angeles Healthcare System, West Los Angeles, CA, West Los Angeles
Recruiting
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT06898879Pain and Major Depressive Disorder
- UCLA Semel Institute, Los Angeles
RecruitingMentions payment for participants
Ages 18 to 75 · All sexes · Updated Aug 11, 2026 · NCT04556890NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Glendale
- Neurocrine Clinical Site, Redlands
- Neurocrine Clinical Site, San Francisco
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT06911112Treatment of Acute Mood Depressive Episode in Borderline Personality Disorder With rTMS
- Stanford Hospital, Stanford
Recruiting
Ages 18 to 80 · All sexes · Updated Aug 11, 2026 · NCT04870255A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
- ATP Clinical Research Orange County, Orange
- Kadima Neuropsychiatry Institute, San Diego
- UCSF Department of Neurology, San Francisco
- and 1 more
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Aug 10, 2026 · NCT07592689NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Chino
- Neurocrine Clinical Site, Los Angeles
- Neurocrine Clinical Site, Stanford
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT06963021A Study of Brenipatide in Adult Participants With Major Depressive Disorder
- Accellacare - Moorpark, Moorpark
- ATP Clinical Research, Orange
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Aug 6, 2026 · NCT07412756Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
- Irvine Clinical Research, Irvine
- CalNeuro Research Group, Los Angeles
- Sunwise Clinical Research LLC, Walnut Creek
RecruitingPhase 2
Ages 18 to 64 · All sexes · Updated Aug 3, 2026 · NCT06547489A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder
- Behavioral Research Specialists, Llc, Glendale
- Irvine Clinical Research, Irvine
- CalNeuro Research Group, Inc., Los Angeles
- and 6 more
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Aug 3, 2026 · NCT06775379Closed-Loop Deep Brain Stimulation for Major Depression
- University of California, San Francisco, San Francisco
Recruiting
Ages 22 to 70 · All sexes · Updated Aug 3, 2026 · NCT04004169A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
- Catalina Research Institute, LLC, Montclair
- Excell Research, Inc, Oceanside
- Anderson Clinical Research, Redlands
- and 3 more
RecruitingPhase 2
Ages 18 to 64 · All sexes · Updated Jul 27, 2026 · NCT07115329Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
- Clinical Research Site, Bellflower
- Clinical Research Site, Chino
- Clinical Research Site, Glendale
- and 7 more
RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Jul 24, 2026 · NCT07484217A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Oceanside
- Neurocrine Clinical Site, Orange
- Neurocrine Clinical Site, San Jose
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT07196501Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Glendale
- Neurocrine Clinical Site, Los Angeles
- Neurocrine Clinical Site, Oceanside
- and 5 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness
- Acacia Clinics, Sunnyvale
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Jul 16, 2026 · NCT06376734Sleep TMS for Depression
- Stanford University, Stanford
RecruitingHealthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Jun 23, 2026 · NCT06824415A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder
- Advanced Research Center /ID# 277537, Anaheim
- Sun Valley Research Center /ID# 277513, Imperial
- Synergy San Diego /ID# 277553, Lemon Grove
- and 4 more
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Jun 15, 2026 · NCT07276997Evaluating tDCS Brain-stimulation in Depression Using MRI
- University of California Los Angeles (UCLA), Los Angeles
Recruiting
Ages 20 to 55 · All sexes · Updated Jun 8, 2026 · NCT05598034A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
- CenExel, Garden Grove
- Behavioral Research Specialists, LLC, Glendale
- Kadima Neuropsychiatry Institute, La Jolla
- and 2 more
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated May 11, 2026 · NCT06524830Mindfulness Engaged Neurostimulation for Depression (MEND II)
- UC San Diego Health Psychiatry, San Diego
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated May 6, 2026 · NCT07512284Regulation of Affect and Physiology in Depression
- University of Southern California, Los Angeles
RecruitingPhase 2Healthy volunteers welcome
Ages 18 to 27 · All sexes · Updated May 4, 2026 · NCT06345859Maintenance rTMS for Depression (Maitr-De)
- University of California, San Diego, San Diego
Recruiting
Ages 18 to 80 · All sexes · Updated Apr 29, 2026 · NCT06938841ATLAS-1: Advanced Trial for Longitudinal Assessment in Salma 1
- Salma Health, La Jolla
- Salma Health, Laguna Hills
RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 14, 2026 · NCT07528014Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder
- Collaborative Neuroscience Network, Garden Grove
RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated Mar 24, 2026 · NCT07226661From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.