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Major Depressive Disorder clinical trials in Los Angeles, CA

12 studies for Major Depressive Disorder are looking for participants at sites in and around Los Angeles (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

RecruitingPhase 3
  • CalNeuro Research Group, Los Angeles
  • Lipov Medical Group, Los Angeles
Ages 18 to 85 · All sexes · Updated Oct 5, 2026 · NCT06793397

Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

Recruiting
  • USC University Hospital, Los Angeles
  • UCLA Department of Psychiatry, Los Angeles
Ages 22 to 70 · All sexes · Updated Aug 28, 2026 · NCT06423430

Pain and Major Depressive Disorder

RecruitingMentions payment for participants
  • UCLA Semel Institute, Los Angeles
Ages 18 to 75 · All sexes · Updated Aug 11, 2026 · NCT04556890

NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Los Angeles
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT06963021

Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

RecruitingPhase 2
  • CalNeuro Research Group, Los Angeles
Ages 18 to 64 · All sexes · Updated Aug 3, 2026 · NCT06547489

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder

RecruitingPhase 3
  • CalNeuro Research Group, Inc., Los Angeles
Ages 18 to 74 · All sexes · Updated Aug 3, 2026 · NCT06775379

Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol

RecruitingPhase 3
  • Clinical Research Site, Los Angeles
Ages 18 to 65 · All sexes · Updated Jul 24, 2026 · NCT07484217

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Los Angeles
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401

Evaluating tDCS Brain-stimulation in Depression Using MRI

Recruiting
  • University of California Los Angeles (UCLA), Los Angeles
Ages 20 to 55 · All sexes · Updated Jun 8, 2026 · NCT05598034

Regulation of Affect and Physiology in Depression

RecruitingPhase 2Healthy volunteers welcome
  • University of Southern California, Los Angeles
Ages 18 to 27 · All sexes · Updated May 4, 2026 · NCT06345859

In-patient SCC TMS

Recruiting
  • UCLA TMS Service and Research Service, Los Angeles
Ages 18 to 65 · All sexes · Updated Sep 23, 2025 · NCT05645575

Study of ALTO-300 in MDD

RecruitingPhase 2
  • Site 209, Los Angeles
Ages 18 to 70 · All sexes · Updated Jul 24, 2025 · NCT05922878

Major Depressive Disorder trials in other cities

Other studies in Los Angeles

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.