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Major Depressive Disorder clinical trials in Florida
31 studies for Major Depressive Disorder are looking for participants at sites in Florida.
Cities in Florida
- Orlando19 studies
- Miami17 studies
- Tampa17 studies
- Jacksonville12 studies
- Hialeah8 studies
- Hollywood7 studies
- West Palm Beach6 studies
- Brandon6 studies
- Miami Gardens5 studies
- Cape Coral4 studies
- Naples3 studies
- Deltona3 studies
- Palm Bay3 studies
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
- CNS Healthcare, Jacksonville
- Accel Research Sites - Maitland, Maitland
- Aqualane Clinical Research, Naples
- and 1 more
RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Sep 25, 2026 · NCT06793397Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder
- Premier Clinical Research Institute, Miami
- Miami Jewish Health System, Miami
- Interventional Psychiatry of Tampa Bay, Tampa
RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Sep 25, 2026 · NCT05850689Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
- Clinical Research of Brandon, Brandon
- AGA Clinical Trials, Hialeah
- Reliable Clinical Research, Hialeah
- and 9 more
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Sep 25, 2026 · NCT06559306A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
- Clinical Neuroscience Solutions Inc. - Jacksonville, Jacksonville
- K2 Medical Research - Maitland, Maitland
- Central Miami Medical Institute Llc., Miami
- and 3 more
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07621237Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder
- Vanda Investigational Site, Fort Myers
- Vanda Investigational Site, Miami
RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Sep 24, 2026 · NCT06830044A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
- Neurocrine Clinical Site, Bonita Springs
- Neurocrine Clinical Site, Hialeah
- Neurocrine Clinical Site, Miami
- and 3 more
RecruitingPhase 4
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07105111A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
- Seaport Investigator Site, Jacksonville
- Seaport Investigator Site, Lauderhill
- Seaport Investigator Site, Orlando
- and 2 more
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Sep 14, 2026 · NCT07065240ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
- New Access Research and Medical Services, Inc., Fort Myers
- The Medici Medical Research, Hollywood
- Clinical Neuroscience Solutions, Inc., Orlando
- and 2 more
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Sep 14, 2026 · NCT07284667A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)
- Gulfcoast Clinical Research Center, Fort Myers
- Sarkis Clinical Trials, Gainesville
- Equipath Health and Research Tampa Bay, Llc, Riverview
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Sep 8, 2026 · NCT07076407A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
- Draig Clinical Site, Hialeah
- Draig Clinical Site, Orlando
- Draig Clinical Site, Orlando
- and 2 more
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 2, 2026 · NCT07610473Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression
- Florida State University, Tallahassee
Recruiting
Ages 18 to 65 · All sexes · Updated Aug 31, 2026 · NCT06132581Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
- USF Health, Tampa
Recruiting
Ages 22 to 70 · All sexes · Updated Aug 28, 2026 · NCT06423430A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder
- UHC Research, Doral
- Reliable Clinical Research, Hialeah
- Nuovida Research Center, Miami
- and 2 more
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Aug 28, 2026 · NCT07573176A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
- Draig Clinical Site, Miami
- Draig Clinical Site, New Port Richey
- Draig Clinical Site, Orlando
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Aug 26, 2026 · NCT07300969NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Hollywood
- Neurocrine Clinical Site, Tampa
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT06911112A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
- Clinical Neuroscience Solutions, LLC (Jacksonville), Jacksonville
- K2 Medical Research (Maitland), Maitland
- Clinical Neuroscience Solutions, LLC (Orlando), Orlando
- and 2 more
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Aug 10, 2026 · NCT07592689NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Maitland
- Neurocrine Clinical Site, Miami
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT06963021A Study of Brenipatide in Adult Participants With Major Depressive Disorder
- Encore Medical Research, Hollywood
- K2 Medical Research - Maitland, Maitland
- Life Medical Research Group Corp, Miami Gardens
- and 5 more
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Aug 6, 2026 · NCT07412756Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
- Clinical Neuroscience Solutions, Inc., Jacksonville
- D&H Pompano Research Center, LLC, Margate
- Premier Clinical Research Institute, Inc., Miami
- and 2 more
RecruitingPhase 2
Ages 18 to 64 · All sexes · Updated Aug 3, 2026 · NCT06547489A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder
- CNS Clinical Research Group, Coral Springs
- Clinical Neuroscience Solutions, Inc., Jacksonville
- Accel Research Sites Lakeland, Lakeland
- and 4 more
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Aug 3, 2026 · NCT06775379A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
- Clinical Neuroscience Solutions, Inc, Jacksonville
- Premier Clinical Research Institute Inc, Miami
- Aqualane Clinical Research, Naples
- and 2 more
RecruitingPhase 2
Ages 18 to 64 · All sexes · Updated Jul 27, 2026 · NCT07115329Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
- Clinical Research Site, Jacksonville
- Clinical Research Site, Miami
- Clinical Research Site, Miami
RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Jul 24, 2026 · NCT07484217A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Miami Gardens
- Neurocrine Clinical Site, Orlando
- Neurocrine Clinical Site, Palm Bay
- and 1 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT07196501Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Hollywood
- Neurocrine Clinical Site, Maitland
- Neurocrine Clinical Site, Maitland
- and 5 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder
- CenExel Hollywood FL /ID# 278200, Hollywood
- Cns Healthcare - Jacksonville /ID# 277658, Jacksonville
- GMI Florida - Central Miami Medical Institute /ID# 278218, Miami
- and 2 more
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Jun 15, 2026 · NCT07276997A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
- CenExel, Hollywood
- Bioresearch Partner, Miami
- University of South Florida, Psychiatry and Behavioral Neurosciences, Tampa
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated May 11, 2026 · NCT06524830Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)
- Autobahn Site #108, Brandon
- Autobahn Site #110, Hialeah
- Autobahn Site #101, Jacksonville
- and 3 more
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Jan 20, 2026 · NCT06633016Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Hollywood
- Neurocrine Clinical Site, Maitland
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 29, 2025 · NCT06786624Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics
- AdventHealth Neuroscience Institute, Orlando
Recruiting
Ages 60 and older · All sexes · Updated Oct 22, 2025 · NCT05877885Study of ALTO-300 in MDD
- Site 159, Clermont
- Site 225, Miami Gardens
- Site 190, Miami Lakes
- and 3 more
RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated Jul 24, 2025 · NCT05922878A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
- Clinical Research Site, Brandon
- Clinical Research Site, Doral
- Clinical Research Site, Hialeah
- and 5 more
RecruitingPhase 4
Ages 18 to 65 · All sexes · Updated Jan 23, 2025 · NCT06223880From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.