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Major Depressive Disorder clinical trials in Florida
33 studies for Major Depressive Disorder are looking for participants at sites in Florida.
Cities in Florida
- Orlando18 studies
- Miami17 studies
- Tampa17 studies
- Jacksonville12 studies
- Hollywood7 studies
- West Palm Beach6 studies
- Hialeah6 studies
- Brandon5 studies
- Palm Bay4 studies
- Miami Gardens4 studies
- Naples4 studies
- Cape Coral3 studies
- Deltona3 studies
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
- CNS Healthcare, Jacksonville
- Accel Research Sites - Maitland, Maitland
- Aqualane Clinical Research, Naples
- and 1 more
RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Nov 13, 2026 · NCT06793397A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
- Seaport Investigator Site, Jacksonville
- Seaport Investigator Site, Lauderhill
- Seaport Investigator Site, Orlando
- and 2 more
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Nov 10, 2026 · NCT07065240A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
- Clinical Neuroscience Solutions, LLC (Jacksonville), Jacksonville
- K2 Medical Research (Maitland), Maitland
- Clinical Neuroscience Solutions, LLC (Orlando), Orlando
- and 1 more
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Nov 9, 2026 · NCT07592689Neuromodulation of Motivation and Reward Oscillations
- The BRAINS Lab at Florida State University, Tallahassee
- The Riddle Lab at Florida State University, Tallahassee
RecruitingHealthy volunteers welcome
Ages 18 to 55 · All sexes · Updated Nov 9, 2026 · NCT07924852Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics
- AdventHealth Neuroscience Institute, Orlando
Recruiting
Ages 60 and older · All sexes · Updated Nov 6, 2026 · NCT05877885ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
- New Access Research and Medical Services, Inc., Fort Myers
- The Medici Medical Research, Hollywood
- Clinical Neuroscience Solutions, Inc., Orlando
- and 2 more
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Nov 5, 2026 · NCT07284667A Study of Brenipatide in Adult Participants With Major Depressive Disorder
- Encore Medical Research, Hollywood
- K2 Medical Research - Maitland, Maitland
- Life Medical Research Group Corp, Miami Gardens
- and 5 more
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Nov 4, 2026 · NCT07412756Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
- Clinical Research of Brandon, Brandon
- Nuovida Research Center, Miami
- Psych Me Medical Research Inc, Tampa
- and 2 more
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Nov 3, 2026 · NCT06559306A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
- JEM Research Institute, Atlantis
- Bradenton Research Center, Inc., Bradenton
- Key Clinical Research, Bradenton
- and 6 more
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Nov 3, 2026 · NCT07775300Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder
- Premier Clinical Research Institute, Miami
- Miami Jewish Health System, Miami
- Interventional Psychiatry of Tampa Bay, Tampa
RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Nov 3, 2026 · NCT05850689A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder
- UHC Research, Doral
- Reliable Clinical Research, Hialeah
- K2 Medical Research, Maitland
- and 4 more
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Nov 3, 2026 · NCT07573176Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Hollywood
- Neurocrine Clinical Site, Maitland
- Neurocrine Clinical Site, Maitland
- and 6 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT06966401A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
- Clinical Research Site, Jacksonville
- Clinical Research Site, Maitland
- Clinical Research Site, Miami
- and 3 more
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT07621237A Study to Evaluate the Safety and Efficacy of ALKS 7290 as an Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder
- Alkermes Investigator Site, Jacksonville
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Oct 28, 2026 · NCT07901179Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder
- CNS Healthcare - Jacksonville, Jacksonville
- Avantis Clinical Research, Miami
- CNS Healthcare of Orlando, Orlando
- and 3 more
RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated Oct 28, 2026 · NCT07226661Study of ALTO-300 in MDD
- Site 221, Tampa
RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated Oct 26, 2026 · NCT05922878Neural Mechanisms of Real-world Emotions and Internalizing
- University of Miami, Coral Gables
RecruitingHealthy volunteers welcome
Ages 18 to 35 · All sexes · Updated Oct 23, 2026 · NCT07891624A Study to Evaluate the Maintenance Effect of Osavampator as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Miami Gardens
- Neurocrine Clinical Site, Orlando
- Neurocrine Clinical Site, Palm Bay
- and 1 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 22, 2026 · NCT07196501Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
- USF Health, Tampa
Recruiting
Ages 22 to 70 · All sexes · Updated Oct 16, 2026 · NCT06423430A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
- Draig Clinical Site, Hialeah
- Draig Clinical Site, Orlando
- Draig Clinical Site, Orlando
- and 2 more
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Oct 14, 2026 · NCT07610473Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
- Clinical Research Site, Jacksonville
- Clinical Research Site, Miami
- Clinical Research Site, Miami
RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Oct 13, 2026 · NCT07484217A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
- Draig Clinical Site, Miami
- Draig Clinical Site, Orlando
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Oct 8, 2026 · NCT07300969Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder
- Vanda Investigational Site, Fort Myers
- Vanda Investigational Site, Miami
RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Sep 24, 2026 · NCT06830044A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
- Neurocrine Clinical Site, Bonita Springs
- Neurocrine Clinical Site, Hialeah
- Neurocrine Clinical Site, Miami
- and 3 more
RecruitingPhase 4
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07105111Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression
- Florida State University, Tallahassee
Recruiting
Ages 18 to 65 · All sexes · Updated Aug 31, 2026 · NCT06132581NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Hollywood
- Neurocrine Clinical Site, Tampa
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT06911112NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Maitland
- Neurocrine Clinical Site, Miami
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT06963021Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
- Clinical Neuroscience Solutions, Inc., Jacksonville
- D&H Pompano Research Center, LLC, Margate
- Premier Clinical Research Institute, Inc., Miami
- and 2 more
RecruitingPhase 2
Ages 18 to 64 · All sexes · Updated Aug 3, 2026 · NCT06547489A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
- Clinical Neuroscience Solutions, Inc, Jacksonville
- Premier Clinical Research Institute Inc, Miami
- Aqualane Clinical Research, Naples
- and 2 more
RecruitingPhase 2
Ages 18 to 64 · All sexes · Updated Jul 27, 2026 · NCT07115329A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder
- CenExel Hollywood FL /ID# 278200, Hollywood
- Cns Healthcare - Jacksonville /ID# 277658, Jacksonville
- GMI Florida - Central Miami Medical Institute /ID# 278218, Miami
- and 2 more
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Jun 15, 2026 · NCT07276997Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)
- Autobahn Site #108, Brandon
- Autobahn Site #110, Hialeah
- Autobahn Site #101, Jacksonville
- and 3 more
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Jan 20, 2026 · NCT06633016Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Hollywood
- Neurocrine Clinical Site, Maitland
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 29, 2025 · NCT06786624A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
- Clinical Research Site, Brandon
- Clinical Research Site, Doral
- Clinical Research Site, Hialeah
- and 5 more
RecruitingPhase 4
Ages 18 to 65 · All sexes · Updated Jan 23, 2025 · NCT06223880From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.