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Major Depressive Disorder clinical trials in Orlando, FL

18 studies for Major Depressive Disorder are looking for participants at sites in and around Orlando (within about 30 miles). Open a study to see who can join and how to contact the study team.

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A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

RecruitingPhase 3
  • Accel Research Sites - Maitland, Maitland · 6 mi away
Ages 18 to 85 · All sexes · Updated Nov 13, 2026 · NCT06793397

A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)

RecruitingPhase 2
  • Seaport Investigator Site, Orlando
Ages 18 to 65 · All sexes · Updated Nov 10, 2026 · NCT07065240

A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

RecruitingPhase 3
  • Clinical Neuroscience Solutions, LLC (Orlando), Orlando
  • K2 Medical Research (Maitland), Maitland · 6 mi away
Ages 18 to 74 · All sexes · Updated Nov 9, 2026 · NCT07592689

Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics

Recruiting
  • AdventHealth Neuroscience Institute, Orlando
Ages 60 and older · All sexes · Updated Nov 6, 2026 · NCT05877885

ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

RecruitingPhase 2
  • Clinical Neuroscience Solutions, Inc., Orlando
Ages 18 to 65 · All sexes · Updated Nov 5, 2026 · NCT07284667

A Study of Brenipatide in Adult Participants With Major Depressive Disorder

RecruitingPhase 3
  • Charter Research - Orlando, Orlando
  • K2 Medical Research - Maitland, Maitland · 6 mi away
Ages 18 to 75 · All sexes · Updated Nov 4, 2026 · NCT07412756

A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

RecruitingPhase 3
  • K2 Medical Research, Maitland · 6 mi away
Ages 18 to 74 · All sexes · Updated Nov 3, 2026 · NCT07573176

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Maitland · 6 mi away
  • Neurocrine Clinical Site, Maitland · 6 mi away
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT06966401

A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 2
  • Clinical Research Site, Orlando
  • Clinical Research Site, Maitland · 6 mi away
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT07621237

Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder

RecruitingPhase 2
  • CNS Healthcare of Orlando, Orlando
Ages 18 to 70 · All sexes · Updated Oct 28, 2026 · NCT07226661

A Study to Evaluate the Maintenance Effect of Osavampator as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Orlando
Ages 18 and older · All sexes · Updated Oct 22, 2026 · NCT07196501

A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression

RecruitingPhase 2
  • Draig Clinical Site, Orlando
  • Draig Clinical Site, Orlando
Ages 18 to 75 · All sexes · Updated Oct 14, 2026 · NCT07610473

A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression

RecruitingPhase 2
  • Draig Clinical Site, Orlando
Ages 18 to 75 · All sexes · Updated Oct 8, 2026 · NCT07300969

NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Maitland · 6 mi away
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT06963021

Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

RecruitingPhase 2
  • Clinical Neuroscience Solutions, Inc., Orlando
Ages 18 to 64 · All sexes · Updated Aug 3, 2026 · NCT06547489

A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder

RecruitingPhase 2
  • Clinical Neuroscience Solutions - Orlando - East South Street /ID# 277558, Orlando
Ages 18 to 65 · All sexes · Updated Jun 15, 2026 · NCT07276997

Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Maitland · 6 mi away
Ages 18 and older · All sexes · Updated Oct 29, 2025 · NCT06786624

A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

RecruitingPhase 4
  • Clinical Research Site, Orlando
  • Clinical Research Site, Orlando
  • Clinical Research Site, Orlando
Ages 18 to 65 · All sexes · Updated Jan 23, 2025 · NCT06223880

Major Depressive Disorder trials in other cities

Other studies in Orlando

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.