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Major Depressive Disorder clinical trials in Orlando, FL
18 studies for Major Depressive Disorder are looking for participants at sites in and around Orlando (within about 30 miles). Open a study to see who can join and how to contact the study team.
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A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
RecruitingPhase 3
- Accel Research Sites - Maitland, Maitland · 6 mi away
A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
RecruitingPhase 2
- Seaport Investigator Site, Orlando
A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
RecruitingPhase 3
- Clinical Neuroscience Solutions, LLC (Orlando), Orlando
- K2 Medical Research (Maitland), Maitland · 6 mi away
Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics
Recruiting
- AdventHealth Neuroscience Institute, Orlando
ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
RecruitingPhase 2
- Clinical Neuroscience Solutions, Inc., Orlando
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
RecruitingPhase 3
- Charter Research - Orlando, Orlando
- K2 Medical Research - Maitland, Maitland · 6 mi away
A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder
RecruitingPhase 3
- K2 Medical Research, Maitland · 6 mi away
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 3
- Neurocrine Clinical Site, Maitland · 6 mi away
- Neurocrine Clinical Site, Maitland · 6 mi away
A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 2
- Clinical Research Site, Orlando
- Clinical Research Site, Maitland · 6 mi away
Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder
RecruitingPhase 2
- CNS Healthcare of Orlando, Orlando
A Study to Evaluate the Maintenance Effect of Osavampator as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 3
- Neurocrine Clinical Site, Orlando
A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
RecruitingPhase 2
- Draig Clinical Site, Orlando
- Draig Clinical Site, Orlando
A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
RecruitingPhase 2
- Draig Clinical Site, Orlando
NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 3
- Neurocrine Clinical Site, Maitland · 6 mi away
Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
RecruitingPhase 2
- Clinical Neuroscience Solutions, Inc., Orlando
A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder
RecruitingPhase 2
- Clinical Neuroscience Solutions - Orlando - East South Street /ID# 277558, Orlando
Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 3
- Neurocrine Clinical Site, Maitland · 6 mi away
A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
RecruitingPhase 4
- Clinical Research Site, Orlando
- Clinical Research Site, Orlando
- Clinical Research Site, Orlando
Major Depressive Disorder trials in other cities
- New York City, NY34 studies
- Boston, MA31 studies
- Atlanta, GA24 studies
- Houston, TX21 studies
- Philadelphia, PA20 studies
- Miami, FL17 studies
- Tampa, FL17 studies
- Chicago, IL15 studies
- San Diego, CA14 studies
- Orange, CA13 studies
- Las Vegas, NV13 studies
- Austin, TX13 studies
Other studies in Orlando
- Non-Small Cell Lung Cancer47 studies
- Obesity33 studies
- Alzheimer's Disease29 studies
- Metastatic Cancer28 studies
- Overweight27 studies
- Type 2 Diabetes25 studies
- Ovarian Cancer24 studies
- Cancer (all types)24 studies
- Breast Cancer23 studies
- Lung Cancer23 studies
- Ulcerative Colitis21 studies
- Colorectal Cancer21 studies
From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.