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Major Depressive Disorder clinical trials in Tampa, FL

17 studies for Major Depressive Disorder are looking for participants at sites in and around Tampa (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

RecruitingPhase 3
  • K2 Medical Research Tampa, Tampa
Ages 18 to 85 · All sexes · Updated Sep 25, 2026 · NCT06793397

Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder

RecruitingPhase 3
  • Interventional Psychiatry of Tampa Bay, Tampa
Ages 18 to 65 · All sexes · Updated Sep 25, 2026 · NCT05850689

Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

RecruitingPhase 3
  • Psych Me Medical Research Inc, Tampa
  • Interventional Psychiatry of Tampa Bay, Tampa
Ages 18 to 74 · All sexes · Updated Sep 25, 2026 · NCT06559306

A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 2
  • K2 Medical Research - Tampa, Tampa
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07621237

ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

RecruitingPhase 2
  • IPTB Clinical Research, Tampa
Ages 18 to 65 · All sexes · Updated Sep 14, 2026 · NCT07284667

A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression

RecruitingPhase 2
  • Draig Clinical Site, Tampa
  • Draig Clinical Site, Tampa
Ages 18 to 75 · All sexes · Updated Sep 2, 2026 · NCT07610473

Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

Recruiting
  • USF Health, Tampa
Ages 22 to 70 · All sexes · Updated Aug 28, 2026 · NCT06423430

A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

RecruitingPhase 3
  • IPTB Clinical Research, Tampa
Ages 18 to 74 · All sexes · Updated Aug 28, 2026 · NCT07573176

NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Tampa
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT06911112

A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

RecruitingPhase 3
  • K2 Medical Research (Tampa), Tampa
Ages 18 to 74 · All sexes · Updated Aug 10, 2026 · NCT07592689

A Study of Brenipatide in Adult Participants With Major Depressive Disorder

RecruitingPhase 3
  • K2 Medical Research - Tampa, Tampa
Ages 18 to 75 · All sexes · Updated Aug 6, 2026 · NCT07412756

A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Tampa
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT07196501

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Tampa
  • Neurocrine Clinical Site, Tampa
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401

A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

RecruitingPhase 2
  • University of South Florida, Psychiatry and Behavioral Neurosciences, Tampa
Ages 18 to 65 · All sexes · Updated May 11, 2026 · NCT06524830

Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

RecruitingPhase 2
  • Autobahn Site #148, Tampa
Ages 18 to 65 · All sexes · Updated Jan 20, 2026 · NCT06633016

Study of ALTO-300 in MDD

RecruitingPhase 2
  • Site 221, Tampa
Ages 18 to 70 · All sexes · Updated Jul 24, 2025 · NCT05922878

Major Depressive Disorder trials in other cities

Other studies in Tampa

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.